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Dwi Nurrahmanto
Fakultas Farmasi Universitas Jember
Health Professions Library & Information Science

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Optimasi Kombinasi Polietilen Glikol dan Polivinilpirolidon sebagai Bahan Pembawa pada Dispersi Padat Glibenklamid dengan Desain Faktorial (Optimization of Polyethilen Glycol and Polyvinylpirolidone Combination as the Carrier in Glibenclamide Solid Disp Hendra Kurniawan; Budipratiwi Wisudyaningsih; Dwi Nurrahmanto
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Glibenclamide is a second-generation sulfonylurea which indicated for the treatment of type II diabetes mellitus. Glibenclamide included in class II of BCS, a drug that have a good permeability but low in solubility. One of techniques that can be used to increase the solubility of glibenclamide is solid dispersion technique. This study was aimed to determine the effect of PEG 6000 and PVP K-30 combination on the melting point of solid dispersion, release of glibenclamide in solid dispersion and the optimum composition of their combination with factorial design method. Melting point response tested using melting point apparatus and percent release response tested by in vitro dissolution test. The results showed that increasing PEG 6000 and PVP K-30 will decrease melting point response and increase percent release response. The optimum composition of those combination was 700 mg of PEG 6000 and 1000 mg of PVP K-30 which provided the smallest melting point at 159,333oC and greatest release as 97.9067%. The optimum composition was characterized using FTIR, DSC and SEM. Keywords: glibenclamide, PEG 6000, PVP K-30, solid dispersion, factorial design
Optimasi Polimer Hidroksipropil Metilselulosa K-4M dan Carbopol 940 pada Sediaan Patch Dispersi Padat Meloksikam (Optimization of Hydroxypropyl Methylcellulose K-4M and Carbopol 940 as Polymer in Solid Dispersion Meloxicam Patch) Indarto Adikusumo; Lidya Ameliana; Dwi Nurrahmanto
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Meloxicam is non steroidal antiinflammatory drug (NSAID) of the enolic acid class which is widely used in treatment of rheumatoid arthritis. Its adverse effects of oral route, which are nausea dan diarrhea could be evaded by using transdermal patch. Meloxicam is practically insoluble in water, therefore it should be made into solid dispersion.The aims of this research was to determine the effect of combination of hydroxypropyl methylcellulose (HPMC) K-4M and carbopol 940 on the in-vitro drug release and moisture content (MC) and to obtain the optimum formula of those polymers using design experts software. Meloxicam patches were prepared into three formulas based on simplex lattice design with the ratio of HPMC K-4M : carbopol 940 that were 1: 0 ; 0.5 : 0.5 and 0 : 1. The results of this research showed that the patch with HMPC K-4M : carbopol 940 of 0:1 gave the best in-vitro drug release and MC. The optimum formula was HPMC K-4M and carbopol 940 with the ratio of 0 : 1 Keywords: meloxicam, solid dispersion, patch, HPMC, carbopol.
Co-Authors Ameliana, Lidya Hendra Kurniawan Indarto Adikusumo