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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding IDJP (Indonesian Journal of Pharmaceutics) Jurnal Ilmiah Manuntung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Ilmu Kefarmasian Indonesia Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Ameliana, Lidya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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PENGEMBANGAN FORMULA KRIM MINYAK SEREH (Cymbopogon citratus) SEBAGAI ANTI NYAMUK TOPIKAL Ameliana, Lidya; Ulfa, Evi Umayah
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 1 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Volatile oils extracted by steam distillation from Cymbopogon citratus were formulated in creams. Theessential oils were then employed as active ingredients in the preparation of insect repellents used in our field trials.These creams containing 0%; 0,5%; 1%; 5%; 10% and 15% (w/w) of volatile oil from Cymbopogon citratus. Thesecreams were evaluated in physical qualities like appearance, pH, spreadibility, and viscosity. And also wereevaluated for their repellency effect against adult female mosquitoes of Aedes aegypti. Results from the field trialsindicate that cream containing 10% of the essential oil from Cymbopogon citratus provided 1071 ± 26.514 seconds ofprotection time against mosquito bites. And the cream containing 15% of the essential oil from Cymbopogoncitratus provided 1097.333 ± 19.139 seconds. It means cream containing 15% of the essential oil is the best formula ofrepellent cream, but does not significantly with cream containing 10 % of the essential oil
PENGARUH PENAMBAHAN ASAM LAKTAT SEBAGAI ENHANCER TERHADAP PENETRASI PERKUTAN KAFEIN DALAM BASIS GEL Ameliana, Lidya; Oktora RKS, Lusia; Dwi N, Devi
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Caffeine is a drug which is effective as an anti-cellulite. Caffeine works by slowing down the lipogenesis process and accelerating the lipolysis process. In this research, caffeine was formulated in Sodium CMC gel base and lactic acid (0, 2, 4, and 6%) as enhancers. The aims of these research was to know the effects of lactic acid as enhancer on pH, viscosity, spreadibility, flowability properties, and percutaneous penetration study of caffeine gel. The results obtained that all formulas have fullfilled of all requirements and it can be concluded that lactic acid lowered the pH, increased viscosity, and lowered spreadibility. The highest flux was obtained the caffeine gel on concentration of 6% lactic acid is equal to 5.43 g/cm2 menit.
OPTIMASI POLIVINILPIROLIDON DAN CARBOPOL PADA SEDIAAN PATCH DISPERSI PADAT PIROKSIKAM Nurahmanto, Dwi; Sabrina, Friska Wira; Ameliana, Lidya
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Piroxicam, a non steroidal anti inflammatory drugs (NSAID), is an oxicam derivative which can be used for treatment of various rheumatic diseases, such as rheumatoid arthritis and osteoarthritis. Piroxicam patch is an affective approach evading piroxicam?s side effect such as peptic ulcer and first pass metabolism. One of the patch components is polymer that the function is to control the speed of drug release from the patch. The aims of this study were to determine the optimum formula of a combination of polyvinylpyrolidone (PVP) and Carbopol to % moisture content (MC) and the flux release in solid dispersion piroxicam patch using Simplex Lattice Design. Piroxicam was prepared in the form of a solid dispersion in PEG 4000 to increase its solubility. The design formula of solid dispersion piroxicam patch made with the ratio PVP : Carbopol, that were 1 : 0; 0.5 : 0.5; 0 : 1. The optimum formula was chosen with the ratio PVP : Carbopol, 1: 0, which gave the best result of % MC and flux release. The result of % MC was 6.91% and the result of flux release was 35.543 µg/cm2.menit1/2.
FORMULA OPTIMIZATION OF ORALLY DISINTEGRATING TABLET CONTAINING MELOXICAM NANOPARTICLES Winarti, Lina; Ameliana, Lidya; Nurahmanto, Dwi
Indonesian Journal of Pharmacy Vol 28 No 1, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (960.501 KB) | DOI: 10.14499/indonesianjpharm28iss1pp53

Abstract

Meloxicam is one of oxicams anti-inflamatory drugs that are effective to relieve toothaches, arthritis, dysmenorrhea, and fever. Meloxicam in this study was milled with High Energy Milling (HEM) method to obtain its nano size and then direct compression method was used to produce Orally Disintegrating Tablet (ODT). ODT is designed to be rapidly dissolved on the tongue within a minute. It can be administered without water or chewing and may improve the bioavailability and effectiveness of the drug, and increase the patient’s adherence. The present study aimed to understand the effects of Ac-Di-Sol and Kollidon CL as superdisintegrants, that were used separately or in combination, on the characteristics of nanoparticles meloxicam ODT. It was also to obtain the best proportion of combination between Ac-Di-Sol and Kollidon CL that can produce the optimum formula of meloxicam ODT. The effects of single or combined superdisintegrants were evaluated using Simplex Lattice Design (SLD). Ac-Di-Sol (X1) and Kollidon CL (X2) were the independent variables, while the dependent variables were friability (Y1), disintegrating time (Y2), wetting time (Y3), and percent meloxicam release after 60 seconds (Y4). Optimization of five nanoparticle meloxicam ODT formulas was conducted using Design Expert 7.1.5. The combination of Ac-Di-Sol 4.05mg (X1) and Kollidon CL 10.95mg (X2) in 150mg nanoparticles meloxicam ODT can produce optimal ODT characteristics. After verification there was no difference between predicted value and observed value with p value > 0.05.
Optimasi Hidroksipropil Metilselulosa dan Carbopol terhadap Moisture Content dan Laju Pelepasan Patch Ibuprofen In Vitro (Optimization of Hydroxypropyl Methylcellulose and Carbopol for Moisture Content and Release Rate of Ibuprofen Patch In Vitro) Kristine Dwi Puspitasari; Dwi Nurahmanto; Lidya Ameliana
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Ibuprofen is non steroidal antiinflammatory drug (NSAID) of the propionic acid class which is widely used for the treatment of rheumatoid arthritis. Ibuprofen patch is an effective approach evading ibuprofen's adverse effect in the GI tract and first pass effect. The function of polymer is to control the drug release from the patch. The aims of this study were to determine the effect of hydroxypropyl methylcellulose (HPMC) K4M and carbopol 934 combination on the moisture content (MC), in-vitro drug release, and to obtain the optimum formula of those polymers. Ibuprofen patch were prepared into three formulas based on simplex lattice design with the ratio of HPMC K4M : carbopol 934, that were 1 : 0, 0.5 : 0.5, and 0 : 1. Design expert software was used to obtain the optimum formula of both polymers. The results of this study showed that patch with HPMC K4M : carbopol 934 (0.5 : 0.5) gave the best MC and the in-vitro drug release. The optimum formula was HPMC K4M and carbopol 934 with the ratio of 0.5 : 0.5. Keywords: ibuprofen, patch, HPMC, carbopol
Pengaruh Komposisi Polivinilpirolidon (PVP K-30) dan Etil Selulosa (EC N-22) terhadap Prosentase Kelembapan Air dan Laju Pelepasan Meloksikam dalam Sediaan Plester Selly Rio Wardhani; Lidya Ameliana; Budipratiwi Wisudyaningsih
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The object of this study was to prepare and evaluated a matrix type transdermal patch of meloxicam using blend of polyvinylpyrolidone (PVP K-30) and ethylcellulose (EC N-22) were 1:9 (Formula I); 2:8 (Formula II); and 3:7 (Formula III). Evaluation of patch is organoleptic, percentage moisture content, and the release of the drug. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% ( = 0.05). The results of organoleptic evaluation of patch dosage, transdermal patches were found yellow, odorless, and dry. Results test percentage moisture content (Formula I) 1.501 ± 0.022 %; (Formula II) 2.206 ± 0.010 %; dan (Formula III) 3.725 ± 0.033 %. Results test flux (Formula I) 455.078 ± 0.835 μg/cm2/menit1/2; (Formula II) 539.08 ± 0.835 μg/cm2/menit1/2; dan (Formula III) 677.851 ± 0.799 μg/cm2/menit1/2. It can be concluded that the combination of polyvinylpyrolidone (PVP K-30) and ethylcellulose (EC N-22) at ratio 3:7 was the best choice for manufacturing transdermal patch based on release profile.
Optimasi Gom Xanthan dan Natrium Karboksimetilselulosa terhadap Mutu Fisik dan Laju Pelepasan Gel Meloksikam In Vitro (Optimization of xanthan gum and Carboxymethylcellulose Sodium on Physical Characteristic and In Vitro Release of Meloxicam from Gel) Rizka Kurnia Cetika; Lidya Ameliana; Lina Winarni
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The aims of this study was to develop and optimize the composition of xanthan gum, carboxymethylcellulose sodium and combination of both that fulfilled the desired requirements in the preparation of meloxicam gel. The prepared gels were evaluated in term of appearance, pH, spreadibilty, viscosity, rheological properties, homogenity and in vitro drug release of meloxicam. The gel was optimized using simplex lattice design method. Influence of gelling agent xanthan gum and carboxymethylcellulose sodium were also investigated. The data was analyzed by statistic program of design expert software trial version 9.0.3.1. All of the evaluation that has been done has fulfilled the optimum requirements desired. The optimal formulation was found the number of xanthan gum is 0.060 – 3 grams and CMC Na is 0.144 – 3 grams in every 100 grams of gels. Keywords: gel, meloxicam, xanthan gum, carboxymethylcellulose sodium
Optimasi Konsentrasi Hidroksipropil Selulosa dan Polivinilpirolidon dalam Sediaan Buccal Film Simvastatin (Optimization Of Hydroxypropyl Cellulose and Polyvynylpyrolidone Concentration in Simvastatin Buccal Film) Nurul Qomariyah; Lidya Ameliana; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3951

Abstract

Simvastatin, an antihyperlipidemia drug belongs to HMG-CoA reductase inhibitor, has extend first-pass metabolism and low bioavailability (5%) with 95-98% protein bond and short half-life (2 hours). The problem of low bioavailability can be solved by buccal delivery systems with producing simvastatin mucoadhesive buccal film. Concentration of HPC and PVP can affect the value of simvastatin release and mucoadhesive strength of film. Optimization using factorial design method determine the optimum concentration of HPC and PVP with highest simvastatin release and mucoadhesive strength. Solvent casting method used for preparation of 4 formula according to factorial design. The result was formula A (FA) with HPC and PVP concentration ratio (50: 10) gave the highest simvastatin release at 95.41% and the highest mucoadhesive strength at 73.37 grams. FTIR analysis results of FA indicated that there were no change in the functional groups on simvastatin as an active ingredient, and the mucoadhesive residence time showed that FA buccal films can be attached to the goat buccal tissues for 186 minutes. Keywords: Buccal film, mucoadhesive, simvastatin, HPC, PVP, factorial design. 
Pengaruh Trietanolamin terhadap Karakteristik Fisika Kimia dan Laju Pelepasan Ibuprofen dalam Sediaan Gel Dispersi Padat Ibuprofen-PEG 6000 (Effect of Triethanolamine on Physicochemical Characteristic and Dissolution Rate of Ibuprofen in Ibuprofen-PEG 600 Tanfidz Alishlah; Budipratiwi Wisudyaningsih; Lidya Ameliana
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The present research has been undertaken with the aim to develop a topical gel formulation of ibuprofen which would avoid side effects of ibuprofen in oral administration. In this study, ibuprofen was made in solid dispersion form with PEG 6000 polymer composition 1 : 1.5 by fusion method. Solid dispersions aims to improve the solubility of ibuprofen. Triethanolamine as an alkalizing agent was added with different concentration in each gel formula which are 1 %, 2 %, and 4 %. They were evaluated for physicochemical properties such as organoleptic, pH, viscosity and in vitro drug release. Based on this research, it can be concluded that the different concentration of triethanolamine doesn’t give the significant effect on viscosity, nonetheless there is a significant effect on pH and dissolution rate of ibuprofen. It is obtained that the highest dissolution rate is F3 with a flux as 216.93 μg/cm2.minutes. Keywords: gel, ibuprofen, solid dispersion, PEG 6000, triethanolamine
Optimasi Suhu dan Lama Pemanasan dalam Pembentukan Kompleks Inklusi Glibenklamid-β-Siklodekstrin dengan Metode Sealed-Heating (Optimization Temperature and Heating Time Formation of Inclusion Complexes Glibenclamide-β-Cyclodextrin by Sealed-Heating Metho Aslyni Putri Suranina Barus; Lidya Ameliana; Dwi Nurahmanto
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Glibenclamide is a second-generation sulfonylurea that used for type II diabetes mellitus. Glibenclamide is included in the biopharmaceutical classification system (BCS) class II, which has a low solubility and high permeability. One effort that can be done to improve the solubility of drug is inclusion complexation. The aims of the study was to determine temperature and heating time on inclusion complexation of glibenclamide-β-cyclodextrin using sealed-heating method. Optimization done using a factorial design for two factors with 22 number of experiments. Inclusion complexes were determined its miosture content, solubility and in vitro dissolution. Moisture content study showed that F1> FB > FA > FAB. The results of solubility study were analyzed statistically using One-Way ANOVA and least significantly different (LSD). Statistical analysis showed that each formula had a significant difference solubility with FAB > FB > FA > F1>Control. Optimization on in vitro dissolution showed that FAB was an optimum formula with drug release of 87.24% within 180 min. This formula was characterized by DSC to observed for broadening, shifting and appearance of new peaks or disappearance of certain peaks. DSC analysis was indicated that inclusion complexation between glibenclamide and β-cyclodextrin was formed. Keywords: glibenclamide, β-cyclodextrin, inclusion complexe, sealed-heating
Co-Authors Alik Almawadah Arafika, Whendy Waliya Aslyni Putri Suranina Barus Budipratiwi Wisudyaningsih desy diana sari Devi Dwi N Devi Dwi N, Devi Dwi Nurahmanto Dwi Nurahmanto Dwi Nurrahmanto Eka Deddy Irawan Elok Rimadani Esti Hendradi Evi Umayah Ulfa Evi Umayah Ulfa Farkha, Fara Sukma Firdatus Sholehah Fitri Wazni Friska Wira Sabrina Gazzali, Amirah Mohd Haris Raudhatuzakinah Dwiputri Indarto Adikusumo Kristine Dwi Puspitasari Kuni Zu’aimah Barikah Lestyo Wulandari Lina Winarni Lina Winarti Lina Winarti Lita Putri Ayu Lestari Lusia Oktora RKS Lusia Oktora RKS, Lusia Lusia Oktora Ruma Kumala Sari Mochammad Yuwono Monica Iwud Rully Pramesthie Nurahmanto, Dwi Nurul Qomariyah Nurul Shalikha Paramayuda, Farukh Putri Mustika Nandani Rizka Kurnia Cetika Sabrina, Friska Wira Sabrina, Friska Wira Selly Rio Wardhani Shalikha, Nurul Tanfidz Alishlah, Tanfidz Viddy Agustian Rosyidi Wirawan Deni Yenika Ayu Mega Dianatri Yudi Wicaksono