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All Journal HAYATI Journal of Biosciences Health Science Journal of Indonesia
I Gusti Ngurah Dwija Putra
Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Warmadewa
Agriculture, Biological Sciences & Forestry Dentistry Earth & Planetary Sciences Health Professions Nursing Public Health

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The Effect of Cang Salak Tea Diet on Apolipoprotein C3 (ApoC3) Gene Expression on Hyperlipidemic Rats Model Burhannuddin; I Wayan Karta; I Gusti Ngurah Dwija Putra; Felicia Kartawidjajaputra
HAYATI Journal of Biosciences Vol. 29 No. 6 (2022): November 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.6.814-823

Abstract

Cardiovascular disease (CVD) is the leading cause of global mortality and disability. Hyperlipidemia is a major risk factor for CVD that can be controlled through medical therapy, appropriate nutrition, and lifestyle. This study aimed to identify the cang salak tea diet’s effect on the ApoC3 gene expression in a hyperlipidemia rat. 18 male Wistar rats were divided equally into three groups. A high-fat-diet-induced two groups of rats, and one group was the control. Once hyperlipidemia had been achieved, one of the two groups was treated with the cang salak tea, and one group was given a standard diet for four weeks. Authenticated rat and liver tissue were collected as a source of RNA isolation. Isolated RNA was used as a reaction template for the relative quantitation qPCR using β-actin as the housekeeping gene. The ApoC3 gene was specifically amplified with a Tm value of 82.73°C, Cq 17-19, and produced a sigmoid curve. The relative expression level of the ApoC3 gene in hyperlipidemia rats fed with the cang salak tea diet was 0.46 times significantly lower than the control (1.17) and P2 (1.32) groups. These results indicate that the cang salak tea has antihyperlipidemic properties to reduce CVD risk.
The Effect of Transcendental Meditation on the Immune Response of Bali Mandara High School Students Kartika Sari; Novitasari Novitasari; Irawan Sukma; Putu Asih Primatanti; Saktivi Harkitasari; I Gusti Ngurah Dwija Putra
Health Science Journal of Indonesia Vol 13 No 1 (2022): (In Press)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v13i1.4672

Abstract

Background:Meditation has become an increasingly popular form of alternative medicine. Many studies have been conducted to assess the health benefits of meditation. In particular, Transcendental Meditation (TM) has been shown to be effective in treating psychological disorders, hypertension, cardiovascular disease, and high cholesterol. Methods: This study has a total sample of 150 students. The study group consisted of 3 groups; control group, TM group 1 (students who regularly practiced TM for 1 year), TM group 2 (students who regularly practiced TM for 2 years). TM Group consists of 50 students for each group. The control group consisted of 50 students who did not use any relaxation techniques. Total eosinophils, neutrophils, lymphocytes, monocytes and hematocrit are counted by an automated quantitative hematology analyzer. Results: The results showed high rates of depression, anxiety and stress among the control group compared to the TM 1 and TM 2 groups. The levels of immune cells indicated that the TM 2 group differed significantly from the control group and the TM 1 group on eosinophils, monocytes and hematocrit (P < 0.05), whereas leucocytes, neutrophils, and lymphocytes showed an increase although no significant differences were observed in the TM 2 group (P> 0.05). Furthermore, there was a strong correlation between the immune response cells (leucocytes, lymphocytes, eosinophils, monocytes, leucocytes, and hematocrit) of the TM group. immune response correlates with increased meditation duration. Conclusion: Based on the results, meditation can help students to reduce depression, anxiety and stress. This study provides information that Transcendental Meditation has health benefits, especially in boosting the immune system.
Co-Authors Burhannuddin Felicia Kartawidjajaputra I Wayan Karta Irawan Sukma Kartika Sari Novitasari Novitasari Putu Asih Primatanti Saktivi Harkitasari