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p-Index From 2021 - 2026
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All Journal HAYATI Journal of Biosciences Journal of Health and Nutrition Research
Felicia Kartawidjajaputra
Nutrifood Research Center, PT. Nutrifood Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Medicine & Pharmacology Nursing Public Health

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The Effect of Cang Salak Tea Diet on Apolipoprotein C3 (ApoC3) Gene Expression on Hyperlipidemic Rats Model Burhannuddin; I Wayan Karta; I Gusti Ngurah Dwija Putra; Felicia Kartawidjajaputra
HAYATI Journal of Biosciences Vol. 29 No. 6 (2022): November 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.6.814-823

Abstract

Cardiovascular disease (CVD) is the leading cause of global mortality and disability. Hyperlipidemia is a major risk factor for CVD that can be controlled through medical therapy, appropriate nutrition, and lifestyle. This study aimed to identify the cang salak tea diet’s effect on the ApoC3 gene expression in a hyperlipidemia rat. 18 male Wistar rats were divided equally into three groups. A high-fat-diet-induced two groups of rats, and one group was the control. Once hyperlipidemia had been achieved, one of the two groups was treated with the cang salak tea, and one group was given a standard diet for four weeks. Authenticated rat and liver tissue were collected as a source of RNA isolation. Isolated RNA was used as a reaction template for the relative quantitation qPCR using β-actin as the housekeeping gene. The ApoC3 gene was specifically amplified with a Tm value of 82.73°C, Cq 17-19, and produced a sigmoid curve. The relative expression level of the ApoC3 gene in hyperlipidemia rats fed with the cang salak tea diet was 0.46 times significantly lower than the control (1.17) and P2 (1.32) groups. These results indicate that the cang salak tea has antihyperlipidemic properties to reduce CVD risk.
Correlation of the cd36 rs1761667 Polymorphism and Lifestyle Factors with Fatty Acid Perception Threshold Dionysius Subali; Elena Soegiarto; Ardy Lizuardi; Rendy Dijaya; Felicia Kartawidjajaputra; Lina Antono; Richie Delano
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.658

Abstract

Genetic variations, such as in the CD36 gene (rs1761667), may influence fat perception and dietary patterns, contributing to obesity. This cross-sectional study involved 87 office workers who underwent genotyping for cd36 rs1761667, sensory testing for oleic acid perception threshold, and assessments of body composition, physical activity, and dietary intake. No direct association was found between the cd36 rs1761667 genotype and the fatty acid perception threshold (p > 0.05). However, stratified analyses revealed that men carrying the A allele (GA/AA, n=23) had a higher body fat percentage compared to those with the GG genotype (n=11). In women, GA/AA carriers consumed more protein, while GG carriers derived a higher proportion of energy from carbohydrates. Among overweight individuals, GG carriers reported higher carbohydrate intake than A allele carriers (p=0.026). These findings suggest that while cd36 rs1761667 may not be a primary determinant of fat taste sensitivity in this cohort, it may contribute modestly to body fat composition and dietary behaviors through interactions with gender and BMI status.
Co-Authors Ardy Lizuardi Burhannuddin Dionysius Subali Elena Soegiarto I Gusti Ngurah Dwija Putra I Wayan Karta Lina Antono Rendy Dijaya Richie Delano