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Miftahuddin Majid Khoeri
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ANTIBACTERIAL ACTIVITIES OF BACTERIAL SYMBIONTS OF SOFT CORAL Sinularia sp. AGAINST TUBERCULOSIS BACTERIA S. Sulistiyani; Sri Achadi Nugraheni; Ocky Karna Radjasa; Agus Sabdono; Miftahuddin Majid Khoeri
JOURNAL OF COASTAL DEVELOPMENT Vol 14, No 1 (2010): Volume 14, Number 1, Year 2010
Publisher : JOURNAL OF COASTAL DEVELOPMENT

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Abstract

Tuberculosis (TB) is caused by Mycobacterium tuberculosis. Although TB is a curable disease, it continues tobe one of the most important infectious causes of death worldwide. Indonesia ranks 3rd on the list of TB highburden countries in the world with 86,000 cases deaths and the Multi Drug Resistant Tuberculosis (MDR TB)estimated cases in Indonesia is 10,000. This research was aimed to isolate and characterize of soft coralSinularia sp.-associated bacteria having antibacterial activity against Tuberculosis bacteria. There were109 isolates collected from Sinularia sp. Two isolates from Sinularia sp.-associated bacteria, SC4TGZ3 andSC4TGZ4 were successfully screened for antibacterial against Tuberculosis bacteria. SC4TGZ3 was found toinhibit the growth of MDR TB strain HE, MDR TB strain SR and H37Rv. Whereas, SC4TGZ4 was found toinhibit the growth of MDR TB strain HE. Based on PCR amplification 16S rDNA softcoral bacateria wereidentified as follows: SC4TGZ3 was closely related to Pseudovibrio sp. and SC4TGZ4 was closely related toAlpha proteobacterium sp.
BIOPROSPECTING OF BACTERIAL SYMBIONT OF Tunicate Didemnum molle FROM SAMBANGAN, KARIMUNJAWA ISLANDS Miftahuddin Majid Khoeri; Ocky Karna Radjasa; Agus Sabdono; Herawati Sudoyo
JOURNAL OF COASTAL DEVELOPMENT Vol 14, No 3 (2011): Volume 14, Number 3, Year 2011
Publisher : JOURNAL OF COASTAL DEVELOPMENT

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Abstract

Coral reef is a productive ecosystem with high biodiversity in the sea and being targeted to find a useful bioactive compound. However, the serious problem in development of bioactive compounds from marine invertebrate is the supply problem, because to get a small amounts of active compounds a massive numbers of sea organisms are needed. Tunicate is an animal in coral reef ecosystem that produces many bioactive compounds with pharmacological activities, such as, antibacterial, antitumor, and anticancer compounds. It has been reported that bacterial symbionts of coral reef invertebrates may synthesize the same compounds as the host. The purposes of this research are to isolate and to identify microbes which have antibacterial activity against MDR bacteria based PCR 16S rRNA and to detect the existence of  PKS and NRPS biosynthetic gene fragments from tunicate bacteria of Didemnum molle. Out of 15 bacterial isolates, one isolate showed antibacterial potential against Escherichia coli and Staphylococcus sp. Molecular identification result showed that TS2A5 bacterium has a homology of 99 % with Virgibacillus sp. strain GSP17 16S ribosomal RNA gene. This isolate was also capable of amplifying  NRPS gene fragment.
Co-Authors Agus Sabdono Herawati Sudoyo Ocky Karna Radjasa S. Sulistiyani Sri Achadi Nugraheni