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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya
Rizki Andini Nawawi
Medical Education Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience Public Health

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POLYMORPHISMS OF THE PROGESTERONE RECEPTOR GENE IN ENDOMETRIOSIS PATIENTS OF SOUTH SUMATRA, INDONESIA Muhammad Irsan Saleh; Rizki Andini Nawawi; Subandrate Subandrate
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I2.17508

Abstract

Polymorphisms of the progesterone receptor gene alter the expressions of two receptor isoforms involved in the regulation of progesterone's antiproliferative effect in endometriotic tissue. This study aims to identify the +331G/A polymorphism of the progesterone receptor gene in endometriosis patients in Palembang, South Sumatra. Identification of +331G/A single-nucleotide polymorphism (SNP) was conducted on 42 endometriosis patients through polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). In this study, twenty-six (61.9%) subjects had heterozygous mutant genotype for the +331G/A SNP. No subject with homozygous mutant genotype for the +331G/A polymorphism was identified. The frequencies of polymorphic alleles for the +331G/A polymorphism was 30.9%. In conclusion, the +331G/A progesterone receptor gene polymorphism was present in endometriosis patients in Palembang, South Sumatra. This finding may warrant further studies to determine whether this polymorphism play a role in the development of endometriosis in the Indonesian population.
Polymorphisms of the Progesterone Receptor Gene in Endometriosis Patients of South Sumatra, Indonesia Muhammad Irsan Saleh; Rizki Andini Nawawi; Subandrate
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 9 No. 2 (2022): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v9i2.287

Abstract

Polimorfisme pada gen reseptor progesteron dapat mengubah ekspresi dua isoform reseptor progesteron, yang terlibat dalam regulasi efek antiproliferatif progesteron di jaringan endometriotik. Studi ini bertujuan mengidentifikasi polimorfisme +331G/A gen reseptor progesteron pada pasien endometriosis di Palembang, Sumatera Selatan. Identifikasi single-nucleotide polymorphism (SNP) +331G/A dilakukan pada 42 pasien endometriosis dengan menggunakan polymerase chain reaction (PCR) dan restriction fragment length polymorphism (RFLP). Pada penelitian ini, didapatkan 26 subjek (61,9%) memiliki genotip heterozigot mutan terhadap SNP +331G/A. Tidak ditemukan subjek dengan genotip homozigot mutan terhadap SNP +331G/A. Frekuensi alel polimorfik SNP +331G/A didapatkan sebesar 30,9%. Dapat disimpulkan bahwa polimorfisme +331G/A gen reseptor progesteron teridentifikasi pada pasien endometriosis di Palembang, Sumatera Selatan. Penelitian selanjutnya diperlukan guna menentukan peran polimorfisme ini dalam patogenesis endometriosis, khususnya pada pasien di Indonesia.
Co-Authors Muhammad Irsan Saleh Subandrate