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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Material Kedokteran Gigi
Trisnawaty K
Biomedical Department Dentistry, Medical Faculty Universitas Sriwijaya
Biochemistry, Genetics & Molecular Biology Dentistry Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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In vitro study of antifungal effect of carica papaya peel var. California extract against Candida albicans Trisnawaty K; Anin Esta Rauna; Siti Rusdiana Puspa Dewi; Pudji Handayani
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/V8I1.10406

Abstract

Candida albicans is a normal microflora in the oral cavity which can be an opportunistic pathogen that could cause oral candidiasis when there are underlying predisposing conditions. Papaya as one of the most widely grown herbal plants in Indonesia has been known to cure diseases. Unused papaya peel only became a waste; however, the papaya peel is known to contain active compounds that have antifungal effect, especially raw ones. This study aimed to determine the antifungal effect of raw papaya peel extract of Californian variety and determine the minimum inhibitory concentration (MIC) of this extract on clinical isolates of C. albicans. This study was an experimental laboratory study with post-test only control group design. Ethanol-based extract of papaya peel was obtained from maceration process using 96% ethanol. Antifungal effect testing was carried out in vitro using disc diffusion method (Kirby-Bauer) on clinical isolates of C. albicans. The concentration of Ethanol extract of papaya peel used consisted of 2.5%, 5%, 10%, and 20% with positive control (nystatin) and negative control (distilled water). The results showed that 2.5%, 5%, 10%, and 20% papaya peel extracts were able to inhibit the growth of C. albicans with 2.5% concentration of raw papaya peel extract as minimum inhibitory concentration. Ethanol extract of raw papaya peel of Californian variety with 2.5%, 5%, 10%, and 20% concentrations has small antifungal effect against clinical isolates of C. albicans.
Pengaruh Penambahan Hidroksiapatit dari Cangkang Telur Ayam Terhadap Kekerasan Permukaan GIC Putri Ajri Mawadara; Martha Mozartha; Trisnawaty K
Jurnal Material Kedokteran Gigi Vol 5 No 2 (2016): JMKG Vol 5 No 2 September 2016
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.966 KB) | DOI: 10.32793/jmkg.v5i2.247

Abstract

Hydroxyapatite (HA) is a bioceramic with excellentbiocompatible properties, and composition and crystal structure similar to apatite in the human dental structure and skeletal system. A number of researchers have attempted to evaluate the effect of the addition of HA powders to increasemechanical properties of restorative dental materials. In this study, HA was synthesized using chicken eggshell as calcium source for synthesizing HA by using precipitation technique. The aim of this study was to determine the effect of incorporation of eggshell-derived HA on the surface hardness GIC (Fuji IX GP). Specimens were divided into two groups: group GIC without incorporation of HA as control group (n = 16) and group GIC with incorporation of 5% HA as experimental group (n = 16). Total of specimens were 32 cylinders 5mm diameter and 2mm height. Surface hardness GIC was measured with vickers microhardness tester. Data wasanalyzed by unpaired T-test. The mean of surface hardness for GIC control group was 51.37 ± 1,63VHN and the experimental group was 56.60 ± 1,22HVN. The results T-test showed a significant difference between groups (p<0.05). It can be concluded thatincorporation of eggshell-derivedHA could increasesurface hardness of GIC.
Co-Authors Anin Esta Rauna Mozartha, Martha Pudji Handayani Putri Ajri Mawadara Siti Rusdiana Puspa Dewi