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ISOLATION, STRUCTURE ANALYSIS, AND ANTIBACTERIAL ACTIVITY OF BIFLAVONOID GB-1 FROM Garcinia tetranda Pierre Novi Sulistyaningrum; Taslim Ersam
Widyariset Vol 15, No 3 (2012): Widyariset
Publisher : Pusbindiklat - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (740.504 KB) | DOI: 10.14203/widyariset.15.3.2012.637–644

Abstract

Garcinia tetranda Pierre (Clusiaceae) was reported as source of flavonoid which has various bioactivities forhealth. Pure compound has been isolated by repeat chromatography techniques (Vacuum Column Chromatography,preparative TLC and TLC). UV, IR, 1H-NMR and 13C-NMR spectroscopic data of isolated compound (isolate)compared with the compound which was found before, and showed same as biflavonoid GB-1 data. Antibacterialassay against Salmonella typhi showed lower activity than chloramphenicol. Biflavonoid GB-1 compound foundin this study is different to the previous study, which all of compounds were classified as xanthones. Therefore,result of this study improves compound variability of Garcinia tetranda. However GB-1 is not potentially used asGram-negative antibacterial agent, especially against Salmonella typhi.
ISOLATION, STRUCTURE ANALYSIS, AND ANTIBACTERIAL ACTIVITY OF BIFLAVONOID GB-1 FROM Garcinia tetranda Pierre Novi Sulistyaningrum; Taslim Ersam
Widyariset Vol 15, No 3 (2012): Widyariset
Publisher : Pusbindiklat - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/widyariset.15.3.2012.637–644

Abstract

Garcinia tetranda Pierre (Clusiaceae) was reported as source of flavonoid which has various bioactivities forhealth. Pure compound has been isolated by repeat chromatography techniques (Vacuum Column Chromatography,preparative TLC and TLC). UV, IR, 1H-NMR and 13C-NMR spectroscopic data of isolated compound (isolate)compared with the compound which was found before, and showed same as biflavonoid GB-1 data. Antibacterialassay against Salmonella typhi showed lower activity than chloramphenicol. Biflavonoid GB-1 compound foundin this study is different to the previous study, which all of compounds were classified as xanthones. Therefore,result of this study improves compound variability of Garcinia tetranda. However GB-1 is not potentially used asGram-negative antibacterial agent, especially against Salmonella typhi.
Co-Authors Taslim Ersam