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All Journal Indonesian Journal of Cancer Chemoprevention
Rio Kurniadi
Department of Chemistry, Mathematics and Natural Sciences Faculty, Tanjungpura University, Jl. A. Yani, Pontianak, Kalimantan Barat, Indonesia.
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Antimicrobial, Antioxidant, Hemolytic Activities and Toxicity of Ethyl Acetate Extract From an Unidentified Coral-Associated Fungus, Aspergillus brevipes RK06 Nofiani, Risa; Kurniadi, Rio; Ardiningsih, Puji
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Marine fungi are one of the potential  and prolific sources to produce unique and novel structure of bioactive compounds. The aim of this research was to explore the biological activities potency from ethyl acetate extract of Aspergillus brevipes  RK06. A. brevipes  RK06 was successfully isolated from an unidentified coral from Randayan Island, Kalimantan Barat. The  extract inhibited the oxidation of linoleic acid (Ferric thiocyanate assay) with a lipid peroxidation inhibition value of 28.44%. The IC50 value of the extract for brine shrimp lethality test was 34.19ug/mL. The hemolytic percentage of the extract for hemolysis on cow erythrocytes was 5.21%. The extract showed a growth inhibition against  Klebsiella pneumonia,  Pseudomonas aeruginosa, and Staphylococcus aureus. Based on the assays, the extract showed a potential citotoxity and both low antioxidant and hemolytic activities.   Key words: antioxidant, hemolytic activity, antimicrobial, toxicity,  Aspergillus brevipes RK06
Co-Authors Puji Ardiningsih Risa Nofiani