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All Journal Pharmacon Abdi Geomedisains Usadha Journal of Pharmacy
Gunawan Setiyadi
Fakultas Farmasi, Universitas Muhammadiyah Surakarta
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing

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Journal : Pharmacon

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Optimasi Co-processed Disintegrant Sodium Starch Glycolate dan Pati Kacang Merah (Phaseolus vulgaris L.) sebagai Bahan Penghancur Fast-Disintegrating Tablet Ondansetron Hydrochloride Rina Suciati; Gunawan Setiyadi
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.15813

Abstract

Ondansetron HCl is a drug that can block serotonin sites that cause nausea and vomiting. Ondansetron administered in fast disintegrating tablet preparations is expected to make it easier for patients to swallow it since it dissolves quickly with the help of saliva. Red bean starch has a moisture content of 9.14% and amylose content of 44.83±1.56% which is useful as a tablet crusher. Sodium starch glycolate (SSG) is a good disintegrant because it has a swelling ability of 300% in water. In this research, co-processed method is used which can reduce the water content and shorten the tablet crushing time effectively. The purpose of this study was to determine the effect of the different ratios of SSG with red bean starch in co-processed disintegrant on the physical properties of Ondansetron FDT, especially disintegration time, friability and dissolution of tablets and to determine the effect of using co-processed disintegrant SSG-red bean starch in the ondansetron FDT formula with formulas that use non-co-processed disintegrants. The optimization method used in this study was the simplex lattice design with components optimized being SSG and red bean starch in a ratio of 0.5:0.5 (FI), 0.75: 0.25 (FII), 0:1 (FIII), 0.25:0.75 (FIV), and 1:0 (FV). The responses used in the optimization were the physical properties of tablets in the form of friability, disintegration time and tablet dissolution. The optimum formula obtained from the experiment was a formula with a ratio of SSG and red bean starch 0.208:0.792. The predicted response of the optimum formula and the response of the verification formula were 0.61% and (0.66 ± 0.08) % friability, respectively, 37.98 seconds of disintegration and (39.90 ± 0.72) seconds and 97 dissolution 88% and (97.45 ± 0.66) %. The response of the verification formula was within the confidence interval of the prediction response, which indicates that the optimization produces a good prediction. The response of the optimum formula was then compared with the response of the same formula but containing a combination of non-co-processed SSG and red bean starch using a t test with a 95% confidence level. The results of the analysis showed that the P-value for friability was 0.1270.05 and dissolution was 0.0590.05, with no significant difference between the two. Meanwhile, the P-value for disintegration time was 0.006 0.05, which means that there was a significant difference between the co-processed and non-co-processed optimum formulas.Keywords: red bean starch, sodium starch glycolate, simplex lattice design, Ondansetron HCl and fast disintegrating tablet.
Optimasi Masker Gel Peel-Off Ekstrak Etanolik Daun Sirih (Piper Betle L.) dengan Kombinasi Carbomer dan Polivinil Alkohol Gunawan Setiyadi; Annisa Qonitah
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.11976

Abstract

Betel leaf (Piper betle L.) is a plant that has potential as a source of natural antioxidants. The purpose of this study was to determine the effect of the combination of carbomer and PVA on the homogeneity, dispersibility, adhesion, viscosity, dry time, elasticity and pH of the gel peel-off mask preparation; obtain the optimum formula and determine the antioxidant activity of the optimum formula. Extraction of betel leaf was carried out using the maceration method with 96% ethanol as a solvent. The experimental design was made using Design Expert software version 11 with the Simplex Lattice Design (SLD) method with the optimized components being carbomer and PVA. The response of physical properties in the form of spreadability, adhesion, pH, viscosity, dry time, and elasticity of each formula is measured and the measurement data is processed with Design Expert software to determine the optimum formula based on predetermined criteria. The verification dosage form is made based on the optimum formula composition produced. The response of the optimum physical properties of the prediction formula was compared with the results of the verification preparation with the One sample t-test. The yield of thick betel leaf extract in this study was 20.26%. The optimum formula has homogeneous characteristics with a distinctive odor of dark green betel leaf and semi-solid form, spreadability 49.25 ± 0.29 cm2, adhesion 4.77 ± 0.22 seconds, pH 7.26 ± 0.119, viscosity 763 ± 12.47 dPas, drying time 29.68 ± 0.52 minutes, elasticity 1.05 ± 0.04%. The antioxidant activity of betel leaf ethanolic extract has an IC50 value of 7.62 µg / mL and the optimum formula has an IC50 value of 111.25 µg / mL.
Co-Authors Andika Permana Annisa Qonitah Ashari Wahyu Budi Aji Febby Arini Fadella Widhiardani Hevi Mifta Kumalasari Hidayah Karuniawati Maryati Maryati Rina Suciati Safitri Indah Kartika Sari Sakinatul Hayati Septi Fatmawati Suprapto Suprapto Vatcha Fitricia Putri Yumna Anis Dhiafanti Yunika Isnanda Pratiwi