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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Jurnal Ilmu Kefarmasian Indonesia
Yuliawati Yuliawati
Department Of Pharmacy, Faculty Of Medicine And Health, University Of Jambi
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Medicine & Pharmacology Public Health

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Uji Aktivitas Hepatoprotektor Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) pada Mencit Putih Jantan yang Diinduksi Parasetamol Yuliawati Yuliawati; Waode Cahaya Widya Putri; Havizur Rahman
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.15732

Abstract

Hepatotoxicity is a drug complication that is often found in long-term drug use because of the role of the liver in metabolizing drugs. Paracetamol is an analgesic and antipyretic drug that is often used by the community and is a safe choice when taken according to the dose. However, if consumed in excess and in the long-term  it causes hepatotoxicity (liver damage). Liver damage can be prevented by giving antioxidant compounds. Rambutan’s leaves contain secondary metabolites of alkaloids, tannins and saponins which are known to have antioxidant potential. The aim of the research is to determine the hepatoprotective activity and the effective dose of Rambutan leaves ethanol extract in male mice induced by patacetamol. The research method was The Randomize Posttest-only Control Group Design using 25 white mice which were divided into 5 groups. The results showed that there was a significant difference in the treatment group of rambutans leaf ethanol extract with the negative control group and a non-significant with the positive control group. Giving  extract doses of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW because it prevents the increase in levels of SGPT, SGOT, relative liver weight and reduces the percentage of damage to the hepatocytes of mice. The effective dose of rambutan’s leaf ethanol extract as a hepatoprotector is 400 mg/kg BW.
Studi Penyembuhan Luka Insisi secara In Vivo Menggunakan Ekstrak Daun Kayu Manis (Cinnamomum burmannii) pada Tikus Putih Jantan Fathnur Sani Kasmadi; Nada Afrilia; Diah Tri Utami; Yuliawati Yuliawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1239

Abstract

Cinnamon leaves are traditional plants that contain secondary metabolites such as flavonoids, tannins, saponins, alkaloids, and phenols. All of these compounds play an essential role in the wound healing process. This study aimed to determine the effects of cinnamon (Cinnamomum burmannii) on incision wound healing in male rats. The research method used a post-test only control group design approach that uses five treatment groups: positive control (Bioplacenton® Gel), negative control (Vaseline flavum), and ethanol extract of cinnamon leaves at concentrations of 10%, 20%, and 30%. The results showed that the ethanol extract of cinnamon leaves affected wound healing, as observed from the day of wound healing, the AUC length of the wound, and levels of hydroxyproline. The statistical test results showed a significant difference between the groups (p<0.05), where the best concentration was 30%, followed by 20% and 10%. Therefore, we concluded that the ethanolic extract of cinnamon leaves can heal wounds in male rats.
Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats Fathnur Sani K; Yuliasati Yuliawati; Havizur Rahman; Agung Giri Samudra
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.721 KB) | DOI: 10.12928/pharmaciana.v12i3.24484

Abstract

Antidiabetic and antihyperlipidemic have a very close relationship for Mellitus Diabetics. In previous research, Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott) had an antihyperglycemic effect. The effect was obtained from the presence of secondary metabolites, namely alkaloids, flavonoids, tannins, saponins, and steroids. This research is expected to be a further test of the antidiabetic and antihyperlipidemic effects of alloxan-induced male white rats. This research used an experimental method. The treatment group was divided into four groups, namely negative control (Na CMC 0,5%), positive control (10 mg/kg BW of glibenclamide), group one (250 mg/kg BW of Ekor Naga leaves extract), and group two (500 mg/kg BW of Ekor Naga leaves extract). Data were taken from blood sugar levels on the days 0th, 7th, 10th, and 14th. Total cholesterol, triglyceride, LDL, and HDL levels were observed on the 14th day. Results were analyzed by one-way ANOVA test. The followed by Duncan’s test. The result of ethanol extract from Ekor Naga leaves showed antidiabetic and antihyperlipidemic activity in alloxan-induced rats, which had a statistically significant difference relative the negative control (p<0,05) decreased the levels of blood glucose, total cholesterol, HDL, LDL, triglycerides. Where the best group is two (500 mg/kg BW of Extract) and followed by group one (250 mg/kg BW of Extract). We concluded that Ekor Naga leaves extract provides activity in the treatment option for patients with diabetes and hyperlipidemia.
Antioxidant Activities of Scrub Body Lotion Extract of Surian Leaves (Toona sinensis) with Powder Scrub Date Seeds (Phoenix dactylifera) Uce Lestari; Yuliawati Yuliawati; Fathnur Sani; Yuliana Yuliana; Muhaimin Muhaimin
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42828

Abstract

Free radicals from exposure to ultraviolet radiation (UVB) cause dull, rough, dry, cracked skin andpremature aging so that they can damage skin tissue and result in fatal skin cancer. To prevent this,antioxidants are needed. Plants that have potential as antioxidants are Surian leaves and date seedswhich contain lots of flavonoids and phenolics. To make it easier to use, it is processed into a scrubbody lotion using a date seed powder scrub (Phoenix dactylifera). This study aimed to find a scrubbody lotion formula that has the best physical properties and is stable during storage and the bestformula has the strongest antioxidant activity. Each formula contains ethanol extract of Surian leaves(Toona sinensis) with a concentration of 0.1%; 0.3%; 0.5%; 0.7%; 0.9%. After that, an evaluationof the physical properties of scrub body lotion preparation was carried out. From the results of theevaluation of the physical properties of the best scrub body lotion preparations, stable in storage andhedonic tests and safe for irritation tests, formula 5 contains ethanol extract of surian leaves with aconcentration of 0.9% and has an antioxidant activity of IC50 28,554 ppm with a very strong category.
Co-Authors Agung Giri Samudra Diah Tri Utami Havizur Rahman Muhaimin Muhaimin Nada Afrilia Sani K, Fathnur Uce Lestari Waode Cahaya Widya Putri Yuliana Yuliana