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All Journal Pharmaciana: Jurnal Kefarmasian Pharmacon Pharmascience PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Havizur Rahman
Jambi University
Health Professions Materials Science & Nanotechnology Medicine & Pharmacology

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Uji Aktivitas Hepatoprotektor Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) pada Mencit Putih Jantan yang Diinduksi Parasetamol Yuliawati Yuliawati; Waode Cahaya Widya Putri; Havizur Rahman
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.15732

Abstract

Hepatotoxicity is a drug complication that is often found in long-term drug use because of the role of the liver in metabolizing drugs. Paracetamol is an analgesic and antipyretic drug that is often used by the community and is a safe choice when taken according to the dose. However, if consumed in excess and in the long-term  it causes hepatotoxicity (liver damage). Liver damage can be prevented by giving antioxidant compounds. Rambutan’s leaves contain secondary metabolites of alkaloids, tannins and saponins which are known to have antioxidant potential. The aim of the research is to determine the hepatoprotective activity and the effective dose of Rambutan leaves ethanol extract in male mice induced by patacetamol. The research method was The Randomize Posttest-only Control Group Design using 25 white mice which were divided into 5 groups. The results showed that there was a significant difference in the treatment group of rambutans leaf ethanol extract with the negative control group and a non-significant with the positive control group. Giving  extract doses of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW because it prevents the increase in levels of SGPT, SGOT, relative liver weight and reduces the percentage of damage to the hepatocytes of mice. The effective dose of rambutan’s leaf ethanol extract as a hepatoprotector is 400 mg/kg BW.
Pengembangan Potensi Ekstrak Belut (Monopterus albus) dalam Menangkal Radikal Bebas Havizur Rahman; Putri Maya Sari; Fitrianingsih Fitrianingsih; Ai Kurniati; Fitri Kurniawati
Jurnal Pharmascience Vol 8, No 1 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i1.9092

Abstract

Penelitian ini bertujuan untuk mengetahui aktifitas antioksidan dari ekstrak belut (Monopterus albus) yang hidup di perairan provinsi jambi. Radikal bebas cenderung menimbulkan reaksi berantai yang apabila terjadi di dalam tubuh akan dapat menimbulkan kerusakan sel yang berlanjut dan terus menerus terutama pada penyakit kronis seperti diabetes, hipertensi dan hiperkolesterol. Pencegahan dapat dilakukan dengan memberikan seyawa antioksidan, salah satunya asam amino. Di dalam al-Quran disebutkan bahwa bangkai yang halal untuk dimakan adalah ikan dan belalang. Belut merupakan salah satu jenis ikan yang memiliki kandungan albumin yang tinggi. Sampel daging belut yang telah difillet dan dipisahkan dari kepalanya, dipotong kecil-kecil dengan ukuran 1,5 cm2 dan dibalut dengan kain tipis dalam sebuah mangkuk, lalu dikukus, dipress, dan disentrifus.  diambil fase air dan minyak dan dibuang pengotornya dengan cara disaring, lalu dikeringkan menggunakan freeze drying sehingga diperoleh ekstrak belut dalam bentuk serbuk. Metode yang digunakan pada penelitian ini adalah Radical Scavenging method menggunakan senyawa kimia DPPH (2,2- difenil-1-pikrilhidrazil). Dari hasil penelitian ditemukan bahwa nilai IC50 ekstrak belut sebesar 29,0816 ppm. Ekstrak belut memiliki potensi menangkal radikal bebas dengan aktifitas kuat. Kata Kunci: Ektstrak Belut, Monopterus albus, Penangkal Radikal Bebas This study aims to determine the antioxidant activity of eel (Monopterus albus) extracts that live in the waters of the province of Jambi. Free radicals tend to cause chain reactions that occur in the body and will cause ongoing and continuous cell damage, especially in chronic diseases such as diabetes, hypertension and hypercholesterolemia. Prevention can be done by providing antioxidants, one of which is amino acids. In the Koran, it is stated that the carcasses that are lawful to eat are fish and grasshoppers. Eel is a type of fish that has a high albumin content. The eel meat sample that has been filled and given from its head, is cut into small pieces with a size of 1.5 cm2 and wrapped in a thin cloth in a container, then steamed, pressed, and centrifuged. the air and oil phases are taken and the impurities are removed by filtering, then they are dried using freeze drying in order to obtain the eel extract in powder form. The method used in this study is the Radical Scavenging Method using the chemical compound DPPH (2,2- diphenyl-1-pikrilhidrazil). From the research results it was found that the IC50 value of eel extract was 29.0816 ppm. Eel extract has the potential to ward off free radicals with strong activity.
Potensi Ekstrak Kering Belut (Monopterus albus) pada Pengobatan Tukak Lambung Havizur Rahman; Putri Maya Sari; Indri Maharini; Bilia Ayu Septiana
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.5727

Abstract

Peningkatan konsumsi akohol, obat-obat anti-inflamasi nonsteroid (OAINS), dan diet yang keliru menjadi penyebab meningkatnya penyakit tukak lambung (ulkus peptikum) di seluruh dunia. Penggunaan obat sintetis jangka panjang sering menimbulkan efek yang tidak diinginkan. Belut diketahui memiliki kadar protein yang tinggi, mirip dengan ikan gabus. Penelitian tentang aktifitas ikan gabus dalam pengobatan luka bakar, luka dalam bekas operasi, serta tukak lambung telah banyak dilakukan. Diperkirakan aktifitas tersebut dipromotori oleh kandungan protein dan asam amino dari ikan. Rancangan penelitian yang digunakan adalah rancangan acak kelompok dengan 5 kelompok perlakuan masing-masing 5 ekor tikus. Diperoleh hasil rata-rata titik pendarahan pada kontrol negatif 7,6: kontrol positif 2,6; dosis ekstrak kering belut 100 mg/kgBB sejumlah 4,2; dosis ekstrak kering belut 200 mg/kgBB sejumlah 1; dan dosis ekstrak kering belut 400 mg/kgBB sejumlah 1. Sedangkan rata-rata pH cairan lambung pada kontrol negatif 4,948: kontrol positif 5,182; dosis ekstrak kering belut 100 mg/kgBB 4,224; dosis ekstrak kering belut 200 mg/kgBB 2,888; dan dosis ekstrak kering belut 400 mg/kgBB 4,89. Secara statistik terdapat perbedaan titik pendarahan yang signifikan antara dosis kontrol positif, 100, 200, dan 400 mg/kgBB dengan kontrol negatif. Tidak ditemukan adanya korelasi antara pH dengan timbulnya titik pendarahan, sehingga pH tidak dapat dijadikan parameter terjadinya tukak lambung. Dapat disimpulkan bahwa ekstrak kering belut memiliki aktifitas sebagai pengobatan tukak lambung dengan dosis terbaik pada 200 mg/kgBB.
Incision wound healing test ethanolic extract gel from Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves in white male rats Fathnur Sanik; Havizur Rahman; Ave Olivia Rahman; Agung Giri Samudra; Cassa de Floris; Muhaimin Muhaimin
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.409 KB) | DOI: 10.12928/pharmaciana.v12i2.22825

Abstract

Ekor naga (Rhaphidophora pinnata (L.f) Schott) leaves have been researched and tested. So, it was known that the chemical content of secondary metabolites effect wound healing. This study aimed to determine the gel effect of ekor naga leaves extracts as a wound healing medicine. The research method evaluated organoleptic, pH, spreadability, and adhesion of gel preparations which were measured every week for four weeks. The testing of gel effect on the wound healing medicine was being performed. In 5 treatment groups namely positive control: Bioplasenton, Formula 0: negative control, Formula 1: 10% extract concentration, Formula 2: 15% extract concentration, and Formula 3: 20% extract concentration. The result obtained were analyzed by one-way ANOVA and continued by the Duncan test with a level of 95% confidence. The research results showed that formula 3 has the best wound healing effect, followed by formulas 2 and 1. The statistical results have a significant difference (p<0,05), but the results of stability observations of the formula two preparation have a stable. Evaluation value for four weeks of observation with a care effect of 95.3%. So, formula 2 is the best formula for stability and testing wound healing effectiveness.
Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats Fathnur Sani K; Yuliasati Yuliawati; Havizur Rahman; Agung Giri Samudra
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.721 KB) | DOI: 10.12928/pharmaciana.v12i3.24484

Abstract

Antidiabetic and antihyperlipidemic have a very close relationship for Mellitus Diabetics. In previous research, Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott) had an antihyperglycemic effect. The effect was obtained from the presence of secondary metabolites, namely alkaloids, flavonoids, tannins, saponins, and steroids. This research is expected to be a further test of the antidiabetic and antihyperlipidemic effects of alloxan-induced male white rats. This research used an experimental method. The treatment group was divided into four groups, namely negative control (Na CMC 0,5%), positive control (10 mg/kg BW of glibenclamide), group one (250 mg/kg BW of Ekor Naga leaves extract), and group two (500 mg/kg BW of Ekor Naga leaves extract). Data were taken from blood sugar levels on the days 0th, 7th, 10th, and 14th. Total cholesterol, triglyceride, LDL, and HDL levels were observed on the 14th day. Results were analyzed by one-way ANOVA test. The followed by Duncan’s test. The result of ethanol extract from Ekor Naga leaves showed antidiabetic and antihyperlipidemic activity in alloxan-induced rats, which had a statistically significant difference relative the negative control (p<0,05) decreased the levels of blood glucose, total cholesterol, HDL, LDL, triglycerides. Where the best group is two (500 mg/kg BW of Extract) and followed by group one (250 mg/kg BW of Extract). We concluded that Ekor Naga leaves extract provides activity in the treatment option for patients with diabetes and hyperlipidemia.
Co-Authors Agung Giri Samudra Ai Kurniati Ave Olivia Rahman Bilia Ayu Septiana Cassa de Floris Fitrianingsih Fitrianingsih Maharini, Indri Muhaimin Muhaimin Putri Maya Sari Putri Maya Sari Sani K, Fathnur Solly Aryza Waode Cahaya Widya Putri Yuliawati Yuliawati