Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Majalah Obat Tradisional
Nunung Yuniarti
Faculty of Pharmacy, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PENGARUH PEMBERIAN KOMBINASI MINYAK ATSIRI RIMPANG TEMULAWAK (Curcuma xanthorriza Roxb.) DAN KURKUMINOIDNYA TERHADAP EFEK ANALGETIK PADA MENCIT Arko Jatmiko Wicaksono; Nunung Yuniarti; Suwijiyo Pramono
Majalah Obat Tradisional Vol 20, No 1 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (917.4 KB) | DOI: 10.22146/tradmedj.7745

Abstract

Penelitian dilakukan untuk mengetahui efek analgetik dari minyak atsiri rimpang temulawak (Curcuma xanthorriza Roxb.), kurkuminoid, dan kombinasi keduanya. Penyarian kurkuminoid dilakukan dengan pelarut etil asetat dan heksan. Minyak atsiri diperoleh dari hasil destilasi air-uap. Uji analgetik dilakukan dengan metode formalin tes (20µL formalin 1%, intraplantar) terhadap mencit jantan galur Swiss (30±5g), umur 2 bulan. Kelompok uji meliputi CMC-Na 0,5 % p.o. (kontrol negatif), indometasin 4 mg/kgBB p.o. dan i.p. (kontrol positif), kurkuminoid 48 mg/kgBB p.o., minyak atsiri 24mg/kgBB p.o, serta kombinasinya p.o. Injeksi formalin dilakukan 1 jam setelah pemejanan sampel. Data licking time diambil pada fase I (menit 0-5) dan fase II (10-30menit) setelah injeksi formalin. Fase I mengindikasikan nyeri yang terjadi pada daerah susunan saraf pusat (SSP) sedangkan fase II pada daerah perifer. Hasil uji terhadap fase I menunjukkan daya analgetik indometasin p.o sebesar (4,96±3,26 %) dan i.p. (4,54±1,65%). Kurkuminoid dan minyak atsiri masing-masing (1,22±0,89%) dan (28,8±8,48%), sedangkan campuran (42,14±5,6%). Kurniawan (2007) melaporkan bahwa besarnya daya analgetik fase I pada morfin 5 mg/kgBB p.o. adalah (69,68±2,17%). Pada fase II minyak atsiri memiliki daya analgetik sebesar (74,63±1,97%), campuran minyak atsiri (24mg/kgBB) dan kurkuminoid (48 mg/kgBB) memiliki daya analgetik sebesar (67,56±0,59%), indometasin i.p. (49,46±1,08%) dan p.o (49,82±0,91%), serta kurkuminoid (44,80±1,46%).
PENGARUH PEMBERIAN FRAKSI LARUT AIR EKSTRAK ETANOLIK PISANG KAPAS (Musa paradisiaca L.) TERHADAP KADAR GLUKOSA DARAH SECARA IN VIVO DAN PELACAKAN SENYAWA AKTIFNYA Nunung Yuniarti; Rina Nur Maulawati; Suwijiyo Pramono
Majalah Obat Tradisional Vol 19, No 2 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (748.089 KB) | DOI: 10.22146/tradmedj.8141

Abstract

Banana is one of Indonesian food which has many pharmacological activities. Pisang kapas (Musa paradisiaca L.), one of Indonesian banana, is well known empirically as laxative, so it can be used in the treatment of constipation. It has been reported that both of chloroformic and ethanolic extract of pisang kapas have antidiabetic activities. However, fractination of those are not yet performed and report about their antidiabetic activities are not yet available. Here we investigated the effect of water-dissolved fraction of ethanolic extract of cotton banana to reduce the blood glucose level in rat model and identified its active ingredient. The oral glucose tolerance method with 60 min glucose loading time was used to induce hyperglicemic condition in rats, either in control group or treatment group. Glibenclamid (positive control), sodium carboxymethyl cellulose (negative control) and the fraction were orally given to the rats in a single dose. To measure blood glucose level photometrically, enzimatic reaction by using diagnostic reagent Glucose GOD FS is applied. Paper chromatography was utilized to identify the ingredient of the fraction qualitatively.  The fraction in dose of 0.25 g/kg reduced blood glucose level by 22.28 ± 0.76 %. The fraction contained reductants in addition to glucose, amino acids, and the acids in plants.
Co-Authors Arko Jatmiko Wicaksono, Arko Jatmiko Rina Nur Maulawati Suwijiyo Pramono