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Indah Purwantini
Faculty of Pharmacy, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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PENGARUH MEDIA PADA PERTUMBUHAN FUNGI ENDOFIT IP-2 DAN PRODUKSI METABOLIT AKTIF INHIBITOR POLIMERISASI HEM Indah Purwantini; Wahyono Wahyono; Mustofa Mustofa; Ratna Asmah Susidarti
Majalah Obat Tradisional Vol 20, No 1 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.469 KB) | DOI: 10.22146/tradmedj.7753

Abstract

Fungi endofit IP-2 adalah fungi endofit yang diisolasi dari tanaman Artemisia annua L. Fungi ini diketahui mempunyai aktivitas sebagai inhibitor polimerisasi hem. Dalam penelitian ini akan diteliti mengenai media yang sesuai untuk pertumbuhan maupun pembentukan metabolit aktifnya serta menentukan waktu yang sesuai untuk pemanenan metabolit aktifnya. Fungi endofit difermentasi dalam 4 jenis media selama 14 hari. Setiap hari dilakukan pengambilan sampel yang akan digunakan untuk mengetahui bobot sel keringnya yang selanjutnya digunakan untuk analisis pertumbuhannya serta digunakan untuk uji aktivitas inhibitor polimerisasi. Uji dilakukan dengan menggunakan metoda yang dikembangkan oleh Bassilico dkk (1998). Data bobot sel kering dan prosentase penghambatan inbihitor polimerisasi dianalisis sehingga diperoleh kurva pertumbuhan dan kurva produksi metabolitnya yang  akan digunakan untuk menentukan  waktu yang tepat untuk memanen metabolit aktifnya. Hasil penelitian menunjukkan bahwa dalam media PDB fungi endofit IP-2 menunjukkan pertumbuhan yang paling baik dan mampu menghasilkan metabolit aktif paling tinggi dibandingkan 3 media lainnya. Dalam media PDB, pada hari ke-7 terlihat jumlah metabolit aktif yang dihasilkan paling banyak sehingga waktu panen metabolit yang tepat adalah pada hari ke-7.
FORMULASI TABLET HISAP EKSTRAK KUNYIT (Curcuma domestica) DENGAN KOMBINASI BAHAN PENGISIMANITOL – AMILUM MANIHOT Farida Haryanti; Indah Purwantini; T. Nanda Saifullah Sulaiman
Majalah Obat Tradisional Vol 17, No 3 (2012)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.864 KB) | DOI: 10.22146/tradmedj.8010

Abstract

Hydroalcoholic extract of turmeric is recommended as supplement to prevent atherosclerosis, but the common dosage form in traditional practices is less practical and unacceptable. It is therefore recommended to be mad into new dosage form, lozenges. This research aims to determine the effect of filler agent manitol-amylum manihot variations to the physical characteristics of granule, tablet, and the flavor of the tablet. The optimum formula was evaluated with simplex lattice design method. The hydro extract of turmeric was made using aquadest 80OC while the alcoholic extract using ethanol 96%. Hydro alcoholic extract was made by mixing both extracts, wet granulated and formulated into five formulas with combination of manitol-amylum manihot ratio. The result showed that the combination of manitol-amylum manihot had affected the tablet hardness, solubility time and flavor acceptance. The formula with the combination manitol-amylum manihot 80% : 20% was found to be the optimum formula.
FORMULASI TABLET HISAP EKSTRAK KUNYIT (Curcuma domestica) DENGAN KOMBINASI BAHAN PENGISIMANITOL – AMILUM MANIHOT T. Nanda Saifullah Sulaiman; Indah Purwantini; Farida Haryanti
Majalah Obat Tradisional Vol 17, No 3 (2012)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.408 KB) | DOI: 10.22146/tradmedj.8013

Abstract

Hydroalcoholic extract of turmeric is recommended as supplement to prevent atherosclerosis, but the common dosage form in traditional practices is less practical and unacceptable. It is therefore recommended to be mad into new dosage form, lozenges. This research aims to determine the effect of filler agent manitol-amylum manihot variations to the physical characteristics of granule, tablet, and the flavor of the tablet. The optimum formula was evaluated with simplex lattice design method. The hydro extract of turmeric was made using aquadest 80OC while the alcoholic extract using ethanol 96%. Hydro alcoholic extract was made by mixing both extracts, wet granulated and formulated into five formulas with combination of manitol-amylum manihot ratio. The result showed that the combination of manitol-amylum manihot had affected the tablet hardness, solubility time and flavor acceptance. The formula with the combination manitol-amylum manihot 80% : 20% was found to be the optimum formula.
Co-Authors Farida Haryanti Mustofa Mustofa Ratna Asmah Susidarti T. Nanda Saifullah Sulaiman Wahyono Wahyono