Garuda - Garba Rujukan Digital

Agustinus Yuswanto

Faculty of Pharmacy, Universitas Gadjah Mada

Author-ID : 3038153

Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document

Claim Missing Document

Articles

PENGARUH PEMBERIAN EKSTRAK ETANOLIK RIMPANG JAHE MERAH TERHADAP FAGOSITOSIS MAKROFAG PADA MENCIT JANTAN YANG DIINFEKSI DENGAN Listeria monocytogenes YS Bintari; Sudarsono Sudarsono; Agustinus Yuswanto
Majalah Obat Tradisional Vol 15, No 2 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Ginger is one of some medicinal plants that has been used to make someone still in the comfortable condition e.g. headache, diarrhea, flatulent, cold, cough, and masuk angin. The purpose of this study was to determine effects of pungent principle extract of the “jahe merah” rhizome in the relation of increasing macrophage phagocytic activation. This method was done by using latex beads.( Leijh et al., (1986) The effects of 10 mg/kgBW, 25 mg/kgBW, and 100 mg/kgBW of pungent principle extract of “jahe merah” rhizome ethanolic extract, that extracted by 70%v/v Ethanol was decided according to the number of latex which was phagocyted by macrophages. The conditioning time was done in 20 days. At 15th day, mice were infected by Listeria monocytogenes. The data was analyzed by Kolmogorov-Smirnov, and one way ANOVA with by 95% confidence level. As the specific parameter of the pungent principle extract were: pungent principle spot 1 : 2 = 6.8:1; 3.27%w/w GAE (Gallic Acid Equivalent) as total phenolic concentration, and IC50 14.57 mg/mL. The result was shown that 100 mg/kgBW of 70% ethanolic extract of “jahe merah” rhizome, was capable to increase macrophage activity. The effect of increasing macrophage phagocytosis of 100 mg/kgBW of 70% ethanolic extract of jahe merah was the same with Echinacea extract and Levamisol.

PENGARUH PEMBERIAN EKSTRAK ZAT PEDAS RIMPANG JAHE EMPRIT YANG DISARI DENGAN ETANOL 70% TERHADAP FAGOSITOSIS MAKROFAG PADA MENCIT JANTAN YANG DIINFEKSI DENGAN Listeria monocytogenes Dyah Mellawati; Sudarsono Sudarsono; Agustinus Yuswanto
Majalah Obat Tradisional Vol 15, No 3 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Immunomodulator has been used as one of the attention to develop herbal medicine. Jahe is one of herbal medicine which is usually used to heal various diseases. Jahe Emprit is one of local name of Jahe in Indonesia. The aim of this research was to investigate the effect of pungent principle containing extract of Jahe emprit rhizome on the macrophage activity compared by levamisol and Echinacea extract. Extraction was done by 70%v/v ethanol. The concentrations of extract were 5 mg/kg B.W; 25 mg/kg B.W; and 100 mg/kg B.W. CMC Na 1,5%w/v was used as solvent control. Levamisol 2,5 mg/kg B.W and Echinacea extract 10 mg/kg B.W were used as positive control. The macrophage ability were measured according to Leijh et al., (1986) that was basically on the amount of latex which was captured by macrophage. The extracts were orally administrated to the Swiss male mice at the dose of 0,2 ml/20 g B.W. The Macrophage activity was analyzed by one way ANOVA at 95% of confidence level. The extract which had specification of 35% relative concentration of pungent principles; 3,554% ± 0,145 % W/W total phenolic substances; 13,70 mg/ml antioxydative value (IC50) at the concentrations of 5 mg/kg B.W and 25 mg/kg B.W could increase phagocytosis ability. The ability of the extract at the concentration 25 mg/kg.B.W had no different with either the Levamizol 2,5 mg/kg. B.W., and Echinacea extract 2,5 mg/kg. B.W.

Title

Found 2 Documents
Search

Abstract

Abstract

Title Search

Found 2 Documents Search

Abstract

Abstract

Title

Found 2 Documents
Search