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All Journal Majalah Obat Tradisional
TN Saifullah Sulaiman
Faculty of Pharmacy, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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OPTIMASI FORMULA TABLET HISAP EKSTRAK KULIT AKAR SENGGUGU (Clerodendrum serratum (L.) Moon.) SEBAGAI SEDIAAN OBAT PENGENCER LENDIR (MUKOLITIK) DENGAN KOMBINASI BAHAN PENGISI LAKTOSA – SORBITOL Wahyono Wahyono; Luthfia Hanifah Kurniati; TN Saifullah Sulaiman
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (870.509 KB) | DOI: 10.22146/tradmedj.8075

Abstract

Senggugu root bark has mucolytic activity and has been used empirically, so it needs to be formulated as lozengeswhich can be used practically and comfortable for the patients. Senggugu root bark powder was extracted by maceration using aethanol 70%. Lozenges was optimized using lactose-sorbitol filler mix through three formulas, formula A ( 100% lactose), formula B (100% sorbitol), formula C (50% lactose-50% sorbitol). Lozenges was made by wet granulation method. The optimum formula was obtained from theresults of physical granul test and lozenges using SLD, and analyzed by its granul flow, hardness, dissolution time, and taste responsiveness, and also qualitative and quantitative analysis. The results show that lactose-sorbitol filler mix can increase hardness and taste responsiveness, decrease granul flow and dissolution time. The oprimum formula from this research is 100% sorbitol:0% lactose. 
Co-Authors Luthfia Hanifah Kurniati Wahyono Wahyono