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All Journal Majalah Obat Tradisional
Dewi Arum Sekti
Faculty of Pharmacy, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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EKSTRAK ETANOLIK DAUN AWAR–AWAR (Ficus septica Burm. f.) MEMACU APOPTOSIS SEL KANKER PAYUDARA MCF-7 MELALUI PENEKANAN EKSPRESI Bcl-2 Dewi Arum Sekti; Muhammad Fithrul Mubarok; Inna Armandani; Sendy Junedy; Edy Meiyanto
Majalah Obat Tradisional Vol 15, No 3 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.241 KB) | DOI: 10.22146/tradmedj.8133

Abstract

Alkaloid fenantroindolisidin showed cytotoxic activity against several cancer cells. Ethanolic leaf extract of Awar-awar proven to increase the cytotoxic activity of chemotherapy agent doxorubicin in MCF-7 cells. This study aims to determine the effect of Ethanolic leaf extract of Awar-awar in apoptosis induction of breast cancer cells MCF-7.Awar-awar leaf powder was extracted by maceration using 70% ethanol and then concentrated to obtain concentrated of Awar-awar. Apoptosis induction was examined by double staining method and the expression of Bcl-2 protein was observed by  immunohistochemistry method. Single treatment of Awar-awar leaf extract  showed the ability of extracts to induce apoptosis and downregulated the expression of Bcl-2 protein. Ethanolic leaf extract of Awar-awar is potential as co-chemotherapeutic agent.
Co-Authors Edy Meiyanto Inna Armandani Muhammad Fithrul Mubarok Sendy Junedy