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All Journal Majalah Obat Tradisional
Finsa Tisna Sari
Faculty of Dentistry, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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EFEK ANTIINFLAMASI EKSTRAK DAUN SEMBUKAN (Paederia scandens) PADA TIKUS WISTAR Evy Tri Utami; Rebecca Azary Kuncoro; Islamy Rahma Hutami; Finsa Tisna Sari; Juni Handajani
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.556 KB) | DOI: 10.22146/tradmedj.8374

Abstract

Inflammation is a protective action that role on defending mechanism to defeat agent causing cell injury. Glucoside of skunkvine (Paederia scandens) has anti-inflammation effect. The aim of this study was to know the anti anti-inflammatory effect of skunkvine (Paederia scandens) extract on artificial edema in Wistar rat. Thirty-five Wistar rats were divided into 7 groups, each group consisted 5 rats. In the control and treatment groups, aquadest (negative control), fenilbutazon (positive control), skunkvine extracts in dose 10mg/kgBW, 20mg/kgBW 30mg/kgBW, 40mg/kgBW, and 50mg/kgBW were administered per orally. In order to induce the edema, one hour after administration, in each group, right hind paw of the rats was injected subcutaneously with by 1% carrageenin. The volume measurement performed with one hour interval for 5 hours assessing with pletysmometer. The data were analyzed by ANOVA. The result of this study showed there was significant difference on group with skunkvine extract 20mg/kg BW to negative control and positive control. In conclusion, that the skunkvine extract 20 mg/kgBW has potency as anti-inflammation substance.
Co-Authors Evy Tri Utami Islamy Rahma Hutami, Islamy Rahma Juni Handajani Rebecca Azary Kuncoro