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EFEK ANTIINFLAMASI EKSTRAK DAUN SEMBUKAN (Paederia scandens) PADA TIKUS WISTAR Utami, Evy Tri; Kuncoro, Rebecca Azary; Hutami, Islamy Rahma; Sari, Finsa Tisna; Handajani, Juni
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Inflamasi merupakan tindakan protektif dalam melawan agen penyebab jejas sel. Tanaman sembukan (Paederia scandens) dengan kandungan glukosida diketahui berpotensi sebagai bahan antiinflamasi. Penelitian ini bertujuan untuk mengetahui efek antiinflamasi ekstrak daun sembukan terhadap edema buatan pada tikus Wistar. Subjek penelitian ini adalah 35 ekor tikus jantan galur Wistar yang dibagi menjadi 7 kelompok, masing-masing berjumlah 5 ekor. Pada kelompok perlakuan dan kontrol yaitu akuades (kontrol negatif), fenilbutazon (kontrol positif), dan perlakuan ekstrak daun sembukan dengan konsentrasi 10mg/kgBB, 20mg/kgBB, 30mg/kgBB, 40mg/kgBB, dan 50mg/kgBB, diberikan secara oral. Telapak kaki belakang kanan tikus disuntikkan secara subkutan karagenan 1% untuk memicu inflamasi. Pengukuran volume edema dilakukan dengan menggunakan pletismometer dalam selang waktu 1 jam selama 5 jam. Data selanjutnya dianalisis menggunakan ANAVA. Hasil penelitian menunjukkan adanya perbedaan bermakna pada pemberian ekstrak daun sembukan 20mg/kgBB dengan kontrol positif dan kontrol negatif. Disimpulkan bahwa ekstrak daun sembukan 20mg/kgBB berpotensi sebagai bahan antiinflamasi.

POTENTIAL OF NASAL AND ORAL SPRAYS OF ALLYL DISULFIDE GARLIC EXTRACT AS PROTECTION AGAINST SARS-COV-2 Silvia Vera Indrawati; Salwa Febria Monica; Iftitah Nabiilah Ramadhani; Siska Nurlivia; Azka Putri Anisa; Islamy Rahma Hutami
ODONTO : Dental Journal Vol 9: Special Issue 1. April 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.0.131-136

Background: Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), a virus that causes COVID-19 disease, occurred in 2019. The prevalence of COVID-19 was increasing and spreading rapidly in several countries including Indonesia. Some efforts have been proposed to reduce the coronavirus outbreak, which is the exploration potentials inhibitor of SARS-CoV-2, vaccination, and improving health protocols by implementing 5M. This study characterized several formulations of nasal spray and evaluated their biological function as antivirus.Method: The garlic was used in this study, crude extract performed by garlic extraction using maseration and evaporated using rotary evaporator. The garlic crude extract was prepared to make nasal and oral sprayer agent and evaluated using thin layer chromatography. Nasal and oral spray composition was modelled and docked with spike glycoprotein of SARS-CoV-2 and angiotensin converting enzyme-2 (ACE-2). Garlic extract showed containing allyl sulfide as bioactive compound in garlic, which was detected at Rf 0.5. biological functions revealed that the component of nasal and oral spray have antiviral agents and block the spike glycoprotein – ACE2 interaction.Result: The allyl disulfide complex detected several active amino acid residues, both with the spike glycoprotein protein and the ACE2 receptor. Conclusion: This study suggested that the nasal and oral spray garlic has the potential as an antiviral, especially inhibiting the interaction between ACE2 and spike glycoprotein. Further in vitro and in vivo studies are required for advance investigation.

EFEK ANTIINFLAMASI EKSTRAK DAUN SEMBUKAN (Paederia scandens) PADA TIKUS WISTAR Evy Tri Utami; Rebecca Azary Kuncoro; Islamy Rahma Hutami; Finsa Tisna Sari; Juni Handajani
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Inflammation is a protective action that role on defending mechanism to defeat agent causing cell injury. Glucoside of skunkvine (Paederia scandens) has anti-inflammation effect. The aim of this study was to know the anti anti-inflammatory effect of skunkvine (Paederia scandens) extract on artificial edema in Wistar rat. Thirty-five Wistar rats were divided into 7 groups, each group consisted 5 rats. In the control and treatment groups, aquadest (negative control), fenilbutazon (positive control), skunkvine extracts in dose 10mg/kgBW, 20mg/kgBW 30mg/kgBW, 40mg/kgBW, and 50mg/kgBW were administered per orally. In order to induce the edema, one hour after administration, in each group, right hind paw of the rats was injected subcutaneously with by 1% carrageenin. The volume measurement performed with one hour interval for 5 hours assessing with pletysmometer. The data were analyzed by ANOVA. The result of this study showed there was significant difference on group with skunkvine extract 20mg/kg BW to negative control and positive control. In conclusion, that the skunkvine extract 20 mg/kgBW has potency as anti-inflammation substance.

Antibacterial Effects of Ethanolic Extract of Bidara (Ziziphus mauritiana Lam) Leaf Against Porphyromonas gingivalis Noor Aziza; Islamy Rahma Hutami; Recita Indraswary; Suryono Suryono
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 11, No 2 (2022): November
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v11i2.15222

The bidara plant (Ziziphus mauritiana Lam) is widely distributed in various Asian countries. Bidara leaves contain secondary metabolites, the main content of which is flavonoids. As a gram-negative anaerobic bacteria, Porphyromonas gingivalis is one of the normal flora of the oral cavity. However, over quantities of this bacteria can promote chronic periodontitis. This research aims to analyze the bidara leaf ethanolic extract as an inhibitory agent of Porphyromonas gingivalis. This research design is experimental laboratory research with a post-test controlled group of Porphyromonas gingivalis inhibition. A total of 25 samples consisted of 5 groups of ethanol extract of bidara leaves at concentrations of 1%, 3%, 9%, positive control betel leaves, and negative control aquadest. Bacteria incubation was held for 48 hours, and the free bacterial zone was analyzed by the One Way ANOVA test. The results of the analysis showed that there was a significant difference between the control group and the treatment group. This study concludes that the ethanol extract of bidara leaves had a strong inhibitory effect on Porphyromonas gingivalis.

QUALITATIVE ANALYSIS OF SANTRI HUSADA CADRES FORMATION AND ORAL DENTAL EXAMINATION AT ASSHODIQIYAH ISLAMIC BOARDING SCHOOL SEMARANG Rizki Amalina; Islamy Rahma Hutami
Jurnal Medali Vol 4: Special Issue 1. Desember 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.4.3.12-18

Background: Dental and oral health problems in Indonesia are still high due to the low number of health workers, both dentists and dental nurses. Therefore, the prevention and promotion of dental and oral health services must be improved formation of dental health cadres in a community. Islamic boarding schools are places of Islamic learning where students or santri live permanently and study together with teachers or Kiai. In a pesantren learning environment, it is essential to pay attention to health, especially the condition of the teeth and mouth, so as not to interfere with the learning process. This community service aims to form cadres and carry out dental and oral health checks by dentists and dental co-operative students, Faculty of Dentistry, Sultan Agung Islamic University (UNISSULA) Semarang.Method: In addition, this activity also aims to change students' behaviour thus they put more attention of the condition of their oral cavity and know the importance dental and oral care treatments according to their oral condition. With direct counselling provided by dentists, the cadres gain understanding and knowledge about the oral cavity, including the arrangement of teeth, various kinds of dental and oral problems, and how to treat them. In addition, the cadres also received training on how to brush their teeth with the right brush and toothpaste provided by the Co-assistant of dental students.Result: With the formation of 12 cadres, it is suggested that promotive, preventive, and referral activities for dental and oral health problems in the Asshodiqiyah Islamic boarding school can continue to run to reduce dental and oral health problems.Conclusion: Cadre activities for students and brushing teeth together can increase knowledge in the field of dental and oral health and the ability to clean the mouth teeth of PP students. Asshodiqiyah. This activity was also able to increase the awareness of the students to be more active in caring for and maintaining the health of their teeth and mouth.

THE IMPACT OF CONSUMING SALMON FISH (SALMO SALAR) ON DENTAL CALCIUM LEVELS IN MICE (MUS MUSCULUS) Sandy Christiono; Naila Salsabila; Rizki Amalina; Welly Anggarani; Islamy Rahma Hutami
Dentino : Jurnal Kedokteran Gigi Vol 8, No 1 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i1.16086

ABSTRACTBackground: Pregnant women require calcium as a vital vitamin. Insufficient calcium intake during pregnancy can result in enamel hypoplasia and cavities in deciduous teeth. It can boost pregnant women's calcium intake with calcium-containing pill formulations and vitamin D; however, this has negative effects such as kidney stone issues. Salmon can be used as a substitute because it has no negative side effects and contains omega 3, which can enhance calcium absorption. Purpose: This study aimed to determine the effect of salmon (Salmo salar) consumption on calcium levels in the teeth of mice (Mus musculus). Method: This study used pregnant mice and a post-test-only control strategy. Pregnant mice were fed salmon combined with CMC (Carboxy Methyl Cellulose) and CMC (Carboxy Methyl Cellulose) alone as a control. The salmon dose administered is 2.17 mg/0.5 ml. Using atomic absorption spectrophotometry, mice dental calcium levels can be determined (AAS). Result: The findings of hypothesis testing with an unpaired t-test of 0.041 revealed a significant difference between the salmon-eating and CMC-consuming groups at p 0.05. (Carboxy Methyl Cellulose). Conclusion: Consuming salmon can significantly increase the calcium content of mouse teeth. Keywords: Dental calcium, Mice (Mus Musculus, Pregnant mice, Salmon (salmo nalar)

POTENTIAL OF NASAL AND ORAL SPRAYS OF ALLYL DISULFIDE GARLIC EXTRACT AS PROTECTION AGAINST SARS-COV-2 Silvia Vera Indrawati; Salwa Febria Monica; Iftitah Nabiilah Ramadhani; Siska Nurlivia; Azka Putri Anisa; Islamy Rahma Hutami
Odonto : Dental Journal Vol 9: Special Issue 1. April 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), a virus that causes COVID-19 disease, occurred in 2019. The prevalence of COVID-19 was increasing and spreading rapidly in several countries including Indonesia. Some efforts have been proposed to reduce the coronavirus outbreak, which is the exploration potentials inhibitor of SARS-CoV-2, vaccination, and improving health protocols by implementing 5M. This study characterized several formulations of nasal spray and evaluated their biological function as antivirus.Method: The garlic was used in this study, crude extract performed by garlic extraction using maseration and evaporated using rotary evaporator. The garlic crude extract was prepared to make nasal and oral sprayer agent and evaluated using thin layer chromatography. Nasal and oral spray composition was modelled and docked with spike glycoprotein of SARS-CoV-2 and angiotensin converting enzyme-2 (ACE-2). Garlic extract showed containing allyl sulfide as bioactive compound in garlic, which was detected at Rf 0.5. biological functions revealed that the component of nasal and oral spray have antiviral agents and block the spike glycoprotein – ACE2 interaction.Result: The allyl disulfide complex detected several active amino acid residues, both with the spike glycoprotein protein and the ACE2 receptor. Conclusion: This study suggested that the nasal and oral spray garlic has the potential as an antiviral, especially inhibiting the interaction between ACE2 and spike glycoprotein. Further in vitro and in vivo studies are required for advance investigation.

PROPOLIS EXTRACT AS ANTI-CORROSIVE AGENT INHIBITS METAL IONIC RELEASE FROM ORTHODONTIC BRACKETS Aditya, Grahita; Wardhana, Erdianto Setya; Hutami, Islamy Rahma; Christiono, Sandy; Pratiwi, Rosa
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18868

Background: A combination of nickel (Ni), chromium (Cr), and iron (Fe) can be found in the stainless steel orthodontic bracket. Ion release takes place as a result of the chemical interaction between metals and the oral environment, which leads to the potential of hypersensitivity during fixed orthodontic treatment. Propolis contains phytochemicals that have the ability to reduce corrosion, making it a potential treatment option. Purpose: to determine the release of Ni, Cr, and Fe in metal brackets in an 8.2% propolis solutionMethod: Four sets of six brackets were made from 24 brackets. Artificial saliva, sodium fluoride, sterilized distilled water (aquabidest), and 8.2% propolis were applied to these brackets. After incubating at 37°C for seven days, ICP EOS measured the metal ions Ni, Cr, and Fe. The analysis revealed significant differences (p<0.05) in ionic release of Ni, Cr, and Fe among groups exposed to sterilized distilled water (aquabidest) and an 8.2% propolis solution. Additionally, the Mann-Whitney test showed substantial Ni ion release differences (p<0.05) between 8.2% propolis solution and sterilized distilled water. The 8.2% propolis solution and sodium fluoride solution released Cr ions differently. Fe ion levels differed between propolis solution 8.2%, sodium fluoride solution, sterilized distilled water, and fake saliva. Conclusion: Propolis affects metal bracket ionic release of Ni, Cr, and Fe. Keywords : Cr and Fe, ions of Ni, propolis solution, Stainless steel bracket

MILK CONSUMPTION AFFECTS THE EXPRESSION OF AMELOGENIN IN AMELOBLAST CELLS DURING AMELOGNESIS (IN VIVO ANALYSIS OF PREGNANT MICE) Hutami, Islamy Rahma; Dewi, Rizqa Citra; Christiono, Sandy; Mujayanto, Rochman
Jurnal Medali Vol 4: Special Issue 1. Desember 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.4.3.63-67

Background: Tooth development during embryonic period is complex process that needs enough nutrition for the formation of healthy dental tissue. Amelogenin are proteins that are secreted by ameloblast in the secretory stage that are importants in the crystal formation and the regulation of email thickness. Milk consumption during pregnancy can increase the expression of amelogenin of ameloblas cell in the tooth development process. This research aims to determine the impact of milk during pregnancy against the expression of amelogenin protein of ameloblast cell in the amelogenesis.Method: This is a true experimental laboratories research using post test only control group design. A total of 12 pregnant female mice (Mus Musculus L.) are used and divided into 2 groups, control group (given sterile aquades) and treatment group (given pregnancy milk). The measurements of amelogenin expression are done in 18th day of pregnancy period. Data were analyzed using Independent sampel of T-test analysis.Result: The result of this study showed that the average amounts of amelogenin expression in the treatment group are lower than the control group. Independent sampel t-test showed that there are significant difference in the amount of amelogenin expression between the control and treatment group (P>0,05)Conclusion: The milk consumption during pregnancy influenced the amelogenin expression of ameloblast cell in the mice fetusâ€™s amelogenesis.

COATING METHODS IN GUIDED BONE REGENERATION PROCEDURES: A LITERATURE REVIEW Sukarno, M. Faiz Faz; Fathurrahman, Helmi; Sunnah, Tahta Danifatis; Hutami, Islamy Rahma
Jurnal Medali Vol 6, No 2 (2024): Media Dental Intelektual September 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.6.2.136-155

Background: The key to the success of implant placement lies in having an adequate alveolar ridge, yet bone loss in the alveolar ridge can occur due to various factors such as periodontal disease, trauma, tumors, and systemic diseases. One technique that can be used to address alveolar bone damage is guided bone regeneration. This study aims to explore and identify coating methods that can be applied to resorbable and non-resorbable membranes in the context of GBR.Method: The research methodology employed is a literature review. The literature sources were searched through PubMed, Scopus, and the Cochrane Library using the Population, Intervention, Comparison, and Outcome (PICO) method. The review analyzed a total of 30 articles, categorized based on the types of membranes and coating methods used. A narrative literature review approach was utilized in writing the review.Result: This literature review analyzed 30 articles. Thirteen coating methods were applied to resorbable membranes, and three coating methods to non-resorbable membranes.Conclusion: Based on the findings of the literature review, the following conclusions can be drawn: (1) Coating methods are applied to overcome the limitations of both resorbable and non-resorbable membranes in the context of GBR. (2) Dip-coating is a commonly used method for both types of membranes in GBR. (3) Dip-coating demonstrates improved mechanical strength and proven enhancement of osteogenic properties, accelerating the bone healing process in GBR. (4) Coating methods can be combined to address the limitations of both resorbable and non-resorbable membranes in GBR procedures.

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