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All Journal Majalah Obat Tradisional Journal of Public Health and Pharmacy
Nurkhasanah Nurkhasanah
Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta
Health Professions Medicine & Pharmacology Public Health

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Effect of Diabetes Condition on Topical Treatment of Binahong Leaf Fraction in Wound Healing Process Kintoko Kintoko; Hanifah Karimatulhajj; Trie Yuni Elfasyari; Ersi Arviana Ihsan; Teguh Adiyas Putra; Puspawan Hariadi; Citra Ariani; Nurkhasanah Nurkhasanah
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (786.835 KB) | DOI: 10.22146/tradmedj.27921

Abstract

Diabetes mellitus (DM) is a metabolic disease which is becoming the first number of health problem in Indonesia, based on the results of the Basic Health Research of Ministry of Health in 2013. One of the diabetes complications affected by high levels of blood glucose is diabetic ulcers wich 85% the number of cases was overed by amputation as the result of improper handling. Herbal treatments could be an alternative treatment of diabetic ulcers, one of them is binahong plant. The results of previous studies have shown the ability of ethanolic extract of binahong leaf in accelerating wound healing in diabetic rats. This study would be a continued study to test five kinds of binahong leaf fractions (FDB) with gradual solvent polarity in accelerating wound healing in diabetic ulcer. Wound healing parameters observed were percentage of wound healing from the wound diameter contraction. The test begins with ethanolic extract of binahong leaf fractionation to produce fractions of hexane (FHDB), chloroform (FKDB), ethyl acetate (FEADB), and ethanol (FEDB). Water fraction (FADB) was obtained from ethanolic leaf extract residues of binahong leaf extraction. Each fraction activity was tested topically twice daily on dorsal of test animals that created wounds using a punch biopsy 5 mm diameters. Grouping of test animals were divided into 13 groups with normal control group (non diabetes), negative control (diabetes + topical application of biocream®), positive control (diabetes + topical application of madecassol), and 10 diabetes groups with topical application of 5 kinds of binahong leaf fractions with each fractions consist of a concentrations of 5% and 10% with biocream® as a vehicle. Diabetic parameters measured include blood glucose levels (KGD) and weight lost percentage (PB%) in day 1 and 10 during a 10-day treatment. The results showed the influence of KGD in the condition of diabetes on wound healing rats diabetic ulcers which topically treated with binahong leaf fractions. FADB 10% has significant differences potention in wound healing process in diabetic rats macroscopically that accelerates wound contraction compared with negative and positive control groups (p<0,05).
Antioxidant Effects of Temulawak and Black Cumin Honey in Stunted Children: A Study in Cirebon Siti Pandawangi TW; Akrom Akrom; Nurkhasanah Nurkhasanah; Ahmad Azrul Zuniarto
Journal of Public Health and Pharmacy Vol. 5 No. 2 (2025)
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i2.5950

Abstract

Introduction: The imbalance between the production of free radicals and the antioxidant defense system in the body will cause the body to experience oxidative stress. This can be caused by chronic malnutrition. In children, this condition causes growth and development failure called stunting. Honey, temulawak and black cumin are herbs with high antioxidant content, formulated in one preparation to test its effectiveness. The purpose of the study was to determine specific descriptions experienced by stunted children and to test the antioxidant effectiveness of preparation temulawak-black cumin honey. Methods: The research method used was quasi-experimental, pre-post design, the research time starts from January-May 2023. The population of Stunting children in the Tegalwangi locus area, Cirebon Regency, the selected samples or subjects are children aged 24-60 months who meet the inclusion criteria. The subjects were divided into 2 groups, namely the treatment group that received the test preparation for 4 months and the control group without the provision of the test preparation. Blood sampling was carried out simultaneously or simultaneously at the village hall with the help of trained analysts. The antioxidant parameters superoxide dismutase, catalase, glutathione peroxidase and free radical parameters Nitric oxide and malondialdehyde. The data obtained will be analysed using an independent t-test. Results: The results of the study on 50 stunted children showed low levels of Superoxide Dismutase, Catalase, Glutathione peroxidase, and free radical parameters Nitric oxide and Malondialdehyde were obtained high. This means that stunted children experience oxidative stress. There was significant antioxidant effectiveness with increased levels of SOD and Catalase in the treatment group (P<0.05), a decrease in NO and MDA in the treatment group (P<0.05) compared to the control group. Conclusion: Temulawak-black cumin honey preparation has activity to reduce oxidative stress in stunted children in Cirebon.
Co-Authors Ahmad Azrul Zuniarto Akrom Akrom Citra Ariani Elfasyari, Trie Yuni Ersi Arviana Ihsan Hanifah Karimatulhajj Kintoko, Kintoko Puspawan Hariadi Putra, Teguh Adiyas Siti Pandawangi TW