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Effect of Diabetes Condition on Topical Treatment of Binahong Leaf Fraction in Wound Healing Process Kintoko Kintoko; Hanifah Karimatulhajj; Trie Yuni Elfasyari; Ersi Arviana Ihsan; Teguh Adiyas Putra; Puspawan Hariadi; Citra Ariani; Nurkhasanah Nurkhasanah
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Diabetes mellitus (DM) is a metabolic disease which is becoming the first number of health problem in Indonesia, based on the results of the Basic Health Research of Ministry of Health in 2013. One of the diabetes complications affected by high levels of blood glucose is diabetic ulcers wich 85% the number of cases was overed by amputation as the result of improper handling. Herbal treatments could be an alternative treatment of diabetic ulcers, one of them is binahong plant. The results of previous studies have shown the ability of ethanolic extract of binahong leaf in accelerating wound healing in diabetic rats. This study would be a continued study to test five kinds of binahong leaf fractions (FDB) with gradual solvent polarity in accelerating wound healing in diabetic ulcer. Wound healing parameters observed were percentage of wound healing from the wound diameter contraction. The test begins with ethanolic extract of binahong leaf fractionation to produce fractions of hexane (FHDB), chloroform (FKDB), ethyl acetate (FEADB), and ethanol (FEDB). Water fraction (FADB) was obtained from ethanolic leaf extract residues of binahong leaf extraction. Each fraction activity was tested topically twice daily on dorsal of test animals that created wounds using a punch biopsy 5 mm diameters. Grouping of test animals were divided into 13 groups with normal control group (non diabetes), negative control (diabetes + topical application of biocream®), positive control (diabetes + topical application of madecassol), and 10 diabetes groups with topical application of 5 kinds of binahong leaf fractions with each fractions consist of a concentrations of 5% and 10% with biocream® as a vehicle. Diabetic parameters measured include blood glucose levels (KGD) and weight lost percentage (PB%) in day 1 and 10 during a 10-day treatment. The results showed the influence of KGD in the condition of diabetes on wound healing rats diabetic ulcers which topically treated with binahong leaf fractions. FADB 10% has significant differences potention in wound healing process in diabetic rats macroscopically that accelerates wound contraction compared with negative and positive control groups (p<0,05).

FORMULASI GEL EKSTRAK KULIT BUAH RENGGAK (Amomum dealbatum Roxb) SEBAGAI SEDIAAN ANTI JERAWAT: GEL FORMULATION OF FRUIT PELL EXTRACT OF RENGGAK (Amomum dealbatum Roxb) AS ANTI ACNE PREPARATION Puspawan Hariadi; Muhlisun Azim; Tri Puspita Yuliana; Yuyun Febriani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Tanaman renggak (Amomum dealbatum Roxb) merupakan tanaman lokal pulau Lombok yang masih belum banyak dimanfaatkan. Tanaman ini dilaporkan mengandung senyawa flavonoid, alkaloid, tannin dan terpenoid. Penelitian ini bertujuan untuk membuat gel dari ekstrak kulit buah renggak dan uji aktivitas terhadap bakteri Propionibacterium acnes. Gel ekstrak kulit buah renggak dibuat dengan variasi konsentrasi 2% dan 4%, uji aktivitas bakteri menggunakan metode difusi agar dengan cara sumuran. Hasil penelitian menunjukan gel ekstrak kulit buah renggak dengan konsentrasi 2% memiliki pH 6, daya lekat 1,64, daya sebar 4,43 serta daya hambat bakteri 2,34 mm. Untuk konsentrasi 4% memiliki pH 6, daya lekat 1,57, daya sebar 4,36 serta daya hambat bakteri 3,20 mm. Gel ektrak kulit buah renggak memiliki zona hambat bakteri dengan kategori lemah, pH dan daya lekat sesuai parameter sediaan gel, sedangkan daya sebar tidak memenuhi persyaratan. Semakin tinggi konsentrasi ekstrak semakin tinggi zona hambat yang dihasilkan.

Pengetahuan masyarakat dan pemanfaatan tanaman obat keluarga di desa toya aikmel utara Muhlisun Azim; Arief Rafsanjani; Tripuspita Yuliana; Puspawan Hariadi
Lentera Negeri Vol 2, No 1 (2021): Lentera Negeri
Publisher : Indonesian Institute For Counseling, Education and Therapy

Family Medicinal Plants (TOGA) is an alternative in achieving GERMAS (Healthy Living Community Movement) as an effort to achieve traditional independent health. The success of the use of TOGA is strongly influenced by the level of public knowledge about the benefits of the type of medicinal plants which has been empirically investigated. The data obtained is qualitative data with descriptive approach analysis method. Data collection was carried out by conducting observations, interviews and technical training to the community in an effort to provide knowledge about TOGA and the creation of a TOGA demonstration plot. The results obtained from this activity are the emergence of public awareness of the use of home yard land for the manufacture of living pharmacies as an effort to achieve independent health and the emergence of public interest in the use of TOGA as a UMKM product in the form of packaged drink sachets as a pilot. The importance of public knowledge about TOGA is needed in supporting the success of achieving independent health and efforts to utilize local biological resources in initiating the manufacture of herbal plant-based UMKM products.

SKRINING EKSTRAK JAMUR ENDOFIT DARI TANAMAN MELINJO (Gnetum gnemon L.) SEBAGAI KANDIDAT ANTIBAKTERI, ANTIJAMUR DAN ANTIOKSIDAN Muhlisun Azim; Puspawan Hariadi; Yuyun Febriani; Tri Puspita Yuliana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Endophytic fungi are potential microorganisms in lead compounds investigation as research objects for antibacterial and antifungal drug candidates. These microorganisms are able to produce various secondary metabolites, moreover they can even be regulated according to the needs of researchers. This is an advantage of endophytic fungi with good adaptability response. This study aims to explore the antibacterial, antifungal and antioxidant activity of endophytic fungi from the branch of the Melinjo tree (Gnetum gnemon L.) by qualitative analysis. This study resulted in 13 potential endophytic fungi extracts to be explored further for their compounds. Based on the results of the TLC test of the fungal extracts with 10% vanillin in H2SO4 as a reagent, it showed that the dominant compounds were alkaloids and polyphenols. The antibacterial activity test of extracts of the endophytic fungi was carried out by the disc diffusion agar method against Staphylococcus aureus and Pseudomonas aeruginosa bacteria, while antifungal agents were used for Candida albicans and Aspergillus clavatus.. Meanwhile, the qualitative test of antioxidants from fungal extracts using the DPPH spray reagent showed positive results of 8 fungal extracts. Screening of endophytic fungi from melinjo represented a source of endophytes potential as antibacterial, antifungal and antioxidant to be developed in exploration of secondary metabolites from natural products of microbial.

Peran Kader Posyandu terhadap Tingkat Kunjungan Masyarakat Hartini Haritani; Puspawan Hariadi; Ewisa Oktresia; Fitriwati Sovia; Baiq Maylinda Gemantari
Jurnal Kesmas Asclepius Vol 4 No 2 (2022): Jurnal Kesmas Asclepius
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/jka.v4i2.4456

This study aims to describe the role of posyandu cadres on the level of visits by the users. The method used in this study is descriptive qualitative with a program evaluation approach. The results obtained from this study are that the number of visits by pregnant women, toddlers, and the elderly has increased. However, a strategy is needed to increase the interest of young women to utilize posyandu so that they can increase the number of visits by adolescents. In conclusion, the role of Posyandu cadres dramatically contributes to the health needs of small communities, especially in villages. Keywords: Cadres, Posyandu, Healthy

Endophyte Extract From Nattle (Urtica dioica L.) Against Staphylococcus aureus and Escherichia coli Azim, Muhlisun; Novasari, Novasari; Hariadi, Puspawan; Febriani, Yuyun; Yuliana, Tri Puspita
ALKIMIA Vol 6 No 1 (2022): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Endophytes are microorganisms that colonize the plant host tissue. Endophytic colonies are able to produce secondary metabolites in accordance with their host plants, endophytes have been found in every plant species studied to date and are recognized as a source of new natural compounds that have the potential to be exploited in medicine. This study aims to isolate and obtain endophytic fungi and to test secondary metabolites that have the potential as antibacterial against Staphylococcus aureus and Escherichia coli. Plant samples were taken around the village of Mamben, Wanasaba. The research method used is experimental laboratory. This research was conducted by isolating and identifying endophytic fungi from nettle stems. Obtained a type of endophytic fungal strain using Potato Dextrose Agar (PDA) media. The production of secondary metabolites of endophytic fungi was obtained by fermentation method using brown rice for a month then macerated for 3 days using methanol solvent and tested for secondary metabolites and antibacterial activity. The endophytic fungal extract of nettle stem contains alkaloids and flavonoids and is able to inhibit the growth of Staphylococcus aureus bacteria with the highest concentration of 60% with an inhibition zone of 18 mm. whereas, the extract of nettle stem endophytic fungus on Escherichia coli has not an inhibition zone.

Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Semangka Merah Sebagai Krim Antijerawat Tri Puspita Yuliana; Hasratul Kusuma; Puspawan Hariadi; Baiq Maylinda Gemantari
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19590

Acne is a problem caused by Propionibacterium acnes bacteria. Red watermelon rind contains lycopene compounds, antioxidants, has tannin and flavonoid compounds and is very good for skin care, free from acne, functions as an antibacterial. The purpose of this study was to formulate ethanol extract of red watermelon rind into anti-acne cream preparation and determine the inhibition zone and determine the red watermelon rind cream has the best antibacterial activity against Propionibacterium acnes bacteria. The method used in this study was experimental, extract concentration of 15%, 20%, 25%. The antibacterial activity test was conducted using the pitting method and evaluated the physical properties of the cream preparation including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results showed that the evaluation of the physical properties of the cream preparation had characteristics in accordance with the evaluation of the preparation carried out at each concentration, including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results of the antibacterial activity test of ethanol extract of red watermelon rind F1, F2, F3 are: 6.76 mm, 8.33 mm, 8.73 mm. The results of the antibacterial activity test of the cream preparation of ethanol extract of red watermelon rind F1, F2, F3 are: 4.47 mm, 6.04 mm, 8.17 mm. It can be concluded that the cream preparation of ethanol extract of red watermelon rind meets the characteristics of cream preparation stability, meets the criteria of good physical properties at concentrations of 15%, 20%, 25%, has weak to moderate category antibacterial activity against Propionibacterium acnes bacteria.

The students learning habit and online learning improvement during covid-19 pandemic Yuyun Febriani; Hartini Haritani; Tri Puspita Yuliana; Puspawan Hariadi; Erma Ewisa Oktresi
Jurnal EDUCATIO: Jurnal Pendidikan Indonesia Vol 8, No 2 (2022): Jurnal EDUCATIO: Jurnal Pendidikan Indonesia
Publisher : Indonesian Institute for Counseling, Education and Therapy (IICET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/1202222459

Coronavirus disease (COVID-19) has rapidly spread around the world, including in Indonesia. Some precautionary health protocol measures have been implemented due to this high infection virus, including campus class suspension. This condition made up the students learning habits has been changed. This research aimed to analyse their learning habit and educator's Improvement in online learning during this pandemic. Qualitative research by observation and questionnaires was used in this study. For observation, this research used controlling and evaluating health faculty and university instruments. One hundred and twenty-seven responses participated in this survey. The inquiries were divided into three significant questions: language and information technology skills, duration time for learning, independent and instructional, and student participation. The research obtained that there was a decline in students learning habits during this pandemic. Thereby the educator’s Improvement, including the learning material, educational delivery method, and evaluation and assessment, must be required. Accordingly, the development and innovation of learning improvement should be continuously done.

FORMULASI GEL EKSTRAK KULIT BUAH RENGGAK (Amomum dealbatum Roxb) SEBAGAI SEDIAAN ANTI JERAWAT: GEL FORMULATION OF FRUIT PELL EXTRACT OF RENGGAK (Amomum dealbatum Roxb) AS ANTI ACNE PREPARATION Puspawan Hariadi; Muhlisun Azim; Tri Puspita Yuliana; Yuyun Febriani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i1.296

Tanaman renggak (Amomum dealbatum Roxb) merupakan tanaman lokal pulau Lombok yang masih belum banyak dimanfaatkan. Tanaman ini dilaporkan mengandung senyawa flavonoid, alkaloid, tannin dan terpenoid. Penelitian ini bertujuan untuk membuat gel dari ekstrak kulit buah renggak dan uji aktivitas terhadap bakteri Propionibacterium acnes. Gel ekstrak kulit buah renggak dibuat dengan variasi konsentrasi 2% dan 4%, uji aktivitas bakteri menggunakan metode difusi agar dengan cara sumuran. Hasil penelitian menunjukan gel ekstrak kulit buah renggak dengan konsentrasi 2% memiliki pH 6, daya lekat 1,64, daya sebar 4,43 serta daya hambat bakteri 2,34 mm. Untuk konsentrasi 4% memiliki pH 6, daya lekat 1,57, daya sebar 4,36 serta daya hambat bakteri 3,20 mm. Gel ektrak kulit buah renggak memiliki zona hambat bakteri dengan kategori lemah, pH dan daya lekat sesuai parameter sediaan gel, sedangkan daya sebar tidak memenuhi persyaratan. Semakin tinggi konsentrasi ekstrak semakin tinggi zona hambat yang dihasilkan.

PENINGKATAN PENGETAHUAN MASYARAKAT MELALUI EDUKASI: PATUHI, OBATI DAN KENDALIKAN DIABETES Hariadi, Puspawan; Oktresia, Erma Ewisa; Sovia, Fitriwati; Gemantari, Baiq Maylinda
Jurnal Abdimas Bina Bangsa Vol. 6 No. 1 (2025): Jurnal Abdimas Bina Bangsa
Publisher : LPPM Universitas Bina Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46306/jabb.v6i1.1703

Diabetes Mellitus (DM) can lead to various complications, both macrovascular and microvascular. Diabetes education interventions play a crucial role in DM management, as they help improve patients' knowledge and adherence to diabetes management strategies. This study involved three sessions: a pre-test, an educational session, and a post-test. Among 53 respondents, the proportion of participants with a high level of knowledge increased from 30 (56.6%) to 43 (81.1%). Meanwhile, those with a low level of knowledge decreased from 10 (18.9%) to 1 (1.9%). This increase in knowledge levels demonstrates the effectiveness of the education provided. The average pre-test knowledge score was 69.06, compared to a post-test score of 86.23, demonstrating a significant improvement. Wilcoxon test analysis showed a significance value of <0.05. Thus, the "Patuhi, Obati dan Kendalikan Diabetes" education program for participants of the Chronic Disease Management Program (Prolanis) significantly enhanced participants' knowledge levels.

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