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All Journal Majalah Obat Tradisional JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)
Achmad Fudholi
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
Health Professions Medicine & Pharmacology Public Health

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Physical and Chemical Stability Test of SNEDDS (Self-nanoemulsifying Drug Delivery System) and Nanoemulsion Ethyl Acetate Fraction of Garcinia mangostana L. Liza Pratiwi; Achmad Fudholi; Ronny Martien; Suwidjiyo Pramono
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.56 KB) | DOI: 10.22146/mot.28533

Abstract

The mangosteen peels (Garcinia mangostana L.) has high free radical scavengers activity. This study aims to determine the physical and chemical conditions that are formulated in SNEDDS and nanoemulsion preparations. SNEDDS was made with various concentrations of Tween 80, PEG 400, and Virgin Coconut Oil (VCO) with a ratio of 4,98:1,02:1. Nanoemulsions were made with the addition of water to SNEDDS. Stability observation results were analyzed by statistics. The results of physical stability test show that all test samples in the research, in nanoemulsion, SNEDDS fraction, base SNEDDS, SNEDDS vitamin E did not undergo separation, precipitation, cracking, and creaming. On the chemical stability test of nanoemulsion and SNEDDS fraction there is no difference between IC50 before and after storage. While on basic SNEDDS and vitamin E nanoemulsion there is a difference between IC50 before and after storage.
The Inventory Control, Storage Facilities and Distribution at Pharmaceutical Industry in Supporting Drugs Availability of JKN Era Satibi Satibi; Achmad Fudholi; Eirene Copalcanty Tuko; Gabriela Larasati Swastiandari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 9, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.444 KB) | DOI: 10.22146/jmpf.43162

Abstract

The drugs availability is still a problem in the health system in Indonesia. The number of JKN participants increasing the need for generic drugs. Pharmaceutical industry has a role to produce affordable and good quality medicines by implementing good supply chain. The purpose of this study was to identify the role of inventory control, storage and distribution facilities in the pharmaceutical industry in supporting drugs availability in the JKN era. This is a descriptive research with qualitative method and uses purposive sampling. Data was collected in depth interview with employees from the PPIC and SCM in Pharma A, Pharma B, Pharma C and Pharma D that collaborated with BPJS Kesehatan and become drug providers in e-catalogue tender. Data analysis consisted of making interview transcripts, interpreting data, and triangulation. The results of the analysis showed that inventory control has an influence in the pharmaceutical industry in supporting the drugs availability due to a mismatch between demand and need, thereby increasing the occurrence of stock over or stock out. Facilities of storage has an influence in the pharmaceutical industry in supporting the drugs availability due to overload storage facilities so that the storage method was not optimal and has to pay other costs to rent warehouses. Distribution has an influence in the pharmaceutical industry in supporting the drugs availability because the costs for distribution must reach a minimum order to be distributed and the choice of transportation modes for distribution may be increased the lead time that caused the drug vacancies.
Co-Authors Eirene Copalcanty Tuko Gabriela Larasati Swastiandari Liza Pratiwi Ronny Martien Satibi Satibi Suwidjiyo Pramono