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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Majalah Obat Tradisional Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical and Clinical Research Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Media Farmasi Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura

Liza Pratiwi

Department Of Pharmaceutical Technology, Faculty Of Medical, Tanjungpura University Pontianak

Author-ID : 483266

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Public Health Social Sciences Other

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FORMULASI DAN AKTIVITAS ANTIOKSIDAN MASKER WAJAH GEL PEEL OFF EKSTRAK METANOL BUAH PEPAYA (Carica papaya L.) Pratiwi, Liza; Wahdaningsih, Sri
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 1, No 2 (2018)
Publisher : Sam Ratulangi University

FORMULASI DAN AKTIVITAS ANTIOKSIDAN MASKER WAJAH GEL PEEL OFF EKSTRAK METANOL BUAH PEPAYA (Carica papaya L.)Liza Pratiwi1), Sri Wahdaningsih1)1) Program Studi Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianakemail : lyza_pratiwi@yahoo.com/085643182838ABSTRACTGel peel off facial mask is one of the alternative dosage that can improve the comfort to use and is expected to increase antioxidant activity from papaya fruit. Papaya has antioxidant activity due to antioxidant components such as beta-carotene, vitamin C, lycopene. The purpose of this research is to know that methanol extract of papaya fruit can be formulated into gel peel off facial mask preparation, determining polivinyl alkohol (PVA) that used for gelling agent gel peel off facial mask concentration with physical, chemical, and antioxidant activity with the best IC50 value. The method used in the extraction is maceration with methanol solvent. PVA used with concentration are 2,5%; 8,75%; and 17,5%. The Physical test include organoleptic test, adhesion test, spreading test and the chemical test with pH test. Based on the result of the research, it can be concluded that the methanol extract of papaya fruit can be formulated into gel face mask preparation, the formula with PVA concentration of 8,75% fulfill organoleptic rules, with adhesion test 20,16 seconds Â± 2,90, spreading test 10,2 cm Â± 1,28, pH value 7,13 Â± 0,06 with the physical and chemical properties of gel peel off facial mask methanol extract of papaya fruit, and formula with concentration 8,75% PVA has the highest antioxidant activity with IC50 value 80,52 Âµg/mL that include as strong antioxidant. Keywords: gel peel off facial mask, methanol extract of papaya fruit, PVA, IC50.ABSTRAKMasker gel peel off merupakan salah satu alternatif sediaan yang dapat meningkatkan kenyamanan penggunaan dan diharapkan dapat meningkatkan aktivitas antioksidan buah pepaya. Pepaya memiliki aktivitas antioksidan karena komponen-komponen antioksidan seperti betakaroten, vitamin C, likopen. Tujuan penelitian ini adalah untuk mengetahui bahwa ekstrak metanol buah pepaya dapat diformulasikan menjadi sediaan masker wajah gel peel off dan menentukan konsentrasi polivinyl alkohol (PVA) yang merupakan bahan dasar masker gel peel off yang memiliki sifat fisik, kimia, dan aktivitas antioksidan dengan nilai IC50 terbaik. Metode yang digunakan pada ekstraksi adalah maserasi dengan pelarut metanol. PVA yang digunakan dengan konsentrasi 2,5%; 8,75%; dan 17,5%. Uji sifat fisik meliputi uji organoleptis, uji daya lekat, uji daya sebar, dan uji sifat kimia menggunakan uji pH. Berdasarkan hasil penelitian, diperoleh hasil bahwa ekstrak metanol buah pepaya dapat diformulasikan menjadi sediaan masker wajah gel peel off, formula dengan konsentrasi PVA 8,75% memenuhi persyaratan organoleptik, daya lekat sebesar 20,16 detik Â± 2,90, daya sebar sebesar 10,2 cm Â± 1,28, nilai pH 7,13 dengan nilai IC50 80,52 Âµg/mL yang termasuk antioksidan kuat.Kata kunci: masker wajah gel peel off, ekstak metanol buah pepaya, PVA, IC50.Â

UJI MIKROSKOPIK EKSTRAK ETANOL 96% HERBA CIPLUKAN (Physalis angulata L.) Istiqomah, Rifqi; Pratiwi, Liza; Luliana, Sri
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Physalis angulata L. is a plant whose extract or infusion has been used by many countries as a popular medicine for the treatment of diseases such as malaria, asthma, hepatitis, dermatitis and rheumatism. The ethanol extract of ciplukan herb has been studied to show non-toxic activity with an LC50 value of more than 1000 ?g / mL so that it is potential to be developed into a dosage form. This study aims to determine the correctness of a sample by identifying its distinctive fragments through microscopic testing. The research method begins with determining the sample to ensure that the plants to be used are appropriate. Then performed microscopic tests and extraction. The results showed that the typical fragments found in the ciplukan herbal simplicia were the transport files, while the yield value of 96% ethanol extract of ciplukan herbs obtained in this study was 2.04%. Keywords: Physalis angulata L., microscopic testing, extraction

Evaluasi Penggunaan Antibiotik pada Pasien Pediatrik Rawat Inap di RSUD dr.Soedarso Pontianak Suhartaty, Lindy; Pratiwi, Liza; Purwanti, Nera Umilia
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 5, No 1 (2021): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Antibiotik merupakan obat yang paling sering diresepkan pada anak-anak. Penggunaan antibiotik yang tidak tepat dapat berkontribusi terhadap terjadinya resistensi yang berdampak pada peningkatan morbiditas, mortalitas dan biaya kesehatan. Penelitian ini bertujuan untuk mengetahui karakteristik pasien dan mengevaluasi penggunaan antibiotik pada pasien pediatrik di RSUD dr Soedarso Pontianak tahun 2019. Metode penelitian yang digunakan adalah cross-sectional dengan pengambilan sampel secara purposive sampling. Hasil penelitian diperoleh 91 pasien yang memenuhi kriteria inklusi. Data yang diperoleh kemudian dievaluasi berdasarkan pedoman yang digunakan yaitu British National Formulary for Children September 2018-2019, Informatorium Obat Nasional Indonesia (IONI) 2014, MIMS 2017/2018 dan Pediatric & Neonatal Dosage Handbook 2013. Pasien pediatrik yang paling banyak diresepkan antibiotik pada laki-laki (54,95%) dan pada rentang usia 5-11 tahun (65,93%). Evaluasi ketepatan penggunaan antibiotik yaitu tepat dosis (62,64%), tepat frekuensi (90,11%), tepat durasi (84,62%) dan tepat rute pemberian (97,80%). Kata Kunci : Antibiotik, Pediatrik, Tepat Dosis, Tepat Frekuensi, Tepat Durasi, Tepat Rute Pemberian

EFEKTIVITAS KRIM ANTIJERAWAT EKSTRAK METANOL DAUN PACAR AIR (Impatiens balsamina L.) Abdurraafi' Maududi Dermawan; Liza Pratiwi; Indri Kusharyanti
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Many studies have found that Impatiens balsamina leaves contain antibacterial activity. The present study was conducted to evaluate antiacne effect from cream of methanolic extract from leaves of Impatiens balsamina L. towards Propionibacterium acnes and Staphylococcus epidermidis, which concentration that gives the most effective antiacne and to evaluate physical and chemical properties of creams. The simplicia was extracted by soxhlet technique and using methanol as solvent. Kirby-Baeur diffusion method was used to measure the antibacterial activity. The extract was formulated in cream with concentration of 10%, 15% and 20%. Evaluation of physical and chemical properties was done by organoleptic testing, spreadability, adhesive force, pH and antibacterial effectiveness. Data was analyzed using R-Commander program 2.14.1 Version. Formula II which contained 15% extract showed the most effective inhibiton to the growth of bacteria. The evaluation of FII cream showed that the cream was homogen, the spreadability was 21,24 + 1,464cm2, adhesive force more than 60 minutes, and pH of 6,53 + 0,057.

Physical and Chemical Stability Test of SNEDDS (Self-nanoemulsifying Drug Delivery System) and Nanoemulsion Ethyl Acetate Fraction of Garcinia mangostana L. Liza Pratiwi; Achmad Fudholi; Ronny Martien; Suwidjiyo Pramono
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The mangosteen peels (Garcinia mangostana L.) has high free radical scavengers activity. This study aims to determine the physical and chemical conditions that are formulated in SNEDDS and nanoemulsion preparations. SNEDDS was made with various concentrations of Tween 80, PEG 400, and Virgin Coconut Oil (VCO) with a ratio of 4,98:1,02:1. Nanoemulsions were made with the addition of water to SNEDDS. Stability observation results were analyzed by statistics. The results of physical stability test show that all test samples in the research, in nanoemulsion, SNEDDS fraction, base SNEDDS, SNEDDS vitamin E did not undergo separation, precipitation, cracking, and creaming. On the chemical stability test of nanoemulsion and SNEDDS fraction there is no difference between IC50 before and after storage. While on basic SNEDDS and vitamin E nanoemulsion there is a difference between IC50 before and after storage.

Assessment of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Ethyl Acetate Fraction from Mangosteen (Garcinia mangostana L.,) Peels to Eschericia coli, Pseudomonas aeroginosa, and Proteus mirabilis Liza Pratiwi
Majalah Obat Tradisional Vol 24, No 3 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.45409

Mangosteen peels have antibacterial activity. SNEDDS has many advantages in developing a drug delivery system to increase the penetration of active compounds. The purpose of this study was to compare the effectiveness of the antibacterial SNEDDS of ethyl acetate fraction from mangosteen peels and ethyl acetate fraction of mangosteen peels without SNEDDS preparation as an antibacterial against Eschericia coli, Pseudomonas aeroginosa, and Proteus mirabilis, that cause diabetic ulcers. This research began with maceration. The thick ethanol extracts were continued and fractionation was carried out with ethyl acetate solvents then was formulated into SNEDDS. The measurement of the antibacterial activity with the bacterial growth inhibition parameters of SNEDDS preparations extracted from ethyl acetate fraction of mangosteen peels was compared with ethyl acetate fraction of mangosteen peels without SNEDDS preparation. Data were analyzed using independent sample T-Test. The results showed the SNEDDS preparation of ethyl acetate fraction from mangosteen peel had activity against both types of bacteria causing diabetic ulcers, but it had no activity against Proteus mirabilis. The results of statistical analysis showed that there were significant differences in the activity of SNEDDS ethyl acetate fraction of mangosteen peels and ethyl acetate fraction of mangosteen peels without SNEDDS in Eschericia coli and Pseudomonas aeruginosa.

Synergistic Interaction of Ethyl Acetate Fraction of Melastoma malabathricum L. Leaves Combined with Ciprofloxacin and Gentamicin Against Eschericia coli Isolate for Diabetic Foot Ulcer Patients Liza Pratiwi; Rafika Sari; Pratiwi Apridamayanti
Majalah Obat Tradisional Vol 26, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.57399

Melastoma malabathricum leaves have active compounds that are thought to have the potential as antibacterial namely flavonoids, phenols and terpenoids. The objective of this study was to find effective drugs formulated from Melastoma malabathricum leaves combined with antibiotics as diabetic foot ulcer therapy to prevent further complications and risk of disability in diabetes mellitus patients. Ciprofloxacin and gentamicin were proven to be resistant antibiotics. In this study, the fraction of Melastoma malabathricum leaves was combined with both types of antibiotics namely ciprofloxacin and gentamicin. The minimum inhibitory concentration (MIC) has been determined against bacterial strains. The determination of MIC (Minimum Inhibitory Concentration) value was done using the Kirby-Bauer disk diffusion method. The interaction of antibiotics with gentamicin and ciprofloxacin was studied in vitro by calculating fractional inhibitory concentration index (FICI). The synergistic effects of the combination Melastoma malabathricum fraction and antibiotics were observed. The results showed that the combination of Melastoma malabathricum fraction with ciprofloxacin and the combination of Melastoma malabathricum fraction with gentamicin against Escherichia coli had a synergistic effect with FICI value of 0,5. The combination of Melastoma malabathricum fraction with ciprofloxacin and the combination of Melastoma malabathricum fraction with gentamicin have the synergistic effect inhibiting the Escherichia coli.

Antibacterial Activity of Self-Nanoemulsifying Drug Delivery System (SNEDDSS) Loaded with Mangosteen (Garcinia mangostana L.,) Peels against Baccilus subtitis, Bacillus cereus, and Staphylococcus aureus isolated from Diabetic Foot Ulcer Patients Liza Pratiwi
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.58116

Diabetic Foot Ulcer is a complication of diabetes mellitus characterized by open sores on the surface of the skin or mucous membranes as well as extensive dead tissue followed by bacterial invasion. Patients with Diabetic Foot Ulcer are resistant to some antibiotics so that alternative therapies such as potential traditional medicines involving mangosteen peels are being developed. Mangosteen peels contain compounds of phenolic, tannin, flavonoid, and xanton. To improve the stability of α-mangostin and improve bioavailability, it requires the preparation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS). This study aimed to analyze the antibacterial effect of optimal SNEDDS of ethyl acetate fraction from mangosteen peels against Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus and to analyze the comparison of inhibition zone diameter between the optimal SNEDDS formula of the ethyl acetate fraction from mangosteen peels and ethyl acetate fraction without SNEDDS against the bacteria. This study began with making 70% ethanol extract from mangosteen peels which was then fractionated to obtain the ethyl acetate fraction. Furthermore, the ethyl acetate fraction was made into optimal SNEDDS formula resulted of Design Expert software with Tween 80, PEG 400, and VCO. The optimal SNEDDS formula of the ethyl acetate fraction from the mangosteen peels was tested for its antibacterial effectiveness against Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus. The results revealed that SNEDDS loaded of ethyl acetate fraction from mangosteen peels had antibacterial activity against both types of Gram-positive bacteria, Bacillus subtilis, and Staphylococcus aureus, which cause diabetes ulcers, and that it did not have antibacterial activity against Bacillus cereus. Moreover, the tested SNEDDS loaded ethyl acetate fraction and ethyl acetate fraction without SNEDDS had strong inhibitory activity against Bacillus subtilis. Meanwhile, they provided such a smaller inhibition zone as tested against Staphylococcus aureus that they had moderate antibacterial activity.

Coffea: The Application of green Components in Cosmetics Formulation Liza Pratiwi
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.66626

In recent years, the use of green components has attracted significant attention because of their safety, various pharmacological effects, various possible formulation applications, and renewable sources. Regarding its development, coffee is a potential candidate for alternatives of synthetic chemicals in cosmetic preparations because it contains active compounds including polyphenols, caffeine, chlorogenic acid, flavonoids, and alkaloids, which are effective for use on the skin as an antioxidant, anti-aging, sunscreen, moisturizer, anti-cellulite, and face brightener. The stratum corneum is the outer layer of skin that is so impenetrable that requires a formulation to help active compounds penetrate its deeper layers. The development of formulation, type, area of origin, part of the coffee used, and the extraction method affects the characteristics of obtained cosmetics.

Efektivitas Gel Anti Jerawat Ekstrak Etanol Rimpang Jahe Merah (Zingiber officinale Rosc. Var. Rubrum) terhadap Propionibacterium acnes dan Staphylococcus epidermidis SYF. OCTY NOVY FISSY; RAFIKA SARI; LIZA PRATIWI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (675.087 KB)

Acne can be caused by bacteria, such as Propionibacterium acnes and Staphylococcus epidermidis. Red ginger (Zingiber officinale Rosc. var. rubrum) has been studied for its antibacterial activity. The aims of this research was to determine the minimum inhibitory concentration of red ginger rhizome ethanol extract against P. acnes and S. epidermidis bacteria and the effectiveness when the extraxt formulated into gel. The simplicia was extracted by soxhlet using 96% ethanol. Diffusion method was used to measure the minimum inhibitory concentration (MIC) of extract. Afterwards, the extract was forrmulated into gel by using three variation of HPMC 4000 and carbopol 934 as gel base with ratio of 70:30 (Formula I), 50:50 (Formula II) and 30:70 (Formula III). Gel evaluation included organoleptic, spreadability, adhesive property, pH and antibacterial effectiveness. The data was analyzed by R-Commander program 2.14.1 Version. The results showed MIC values are 0.45% against P. acnes and 0.5% against S.epidermidis. The results of evaluation for 30 days of storage showed that the gels had stable pH and adhesion, homogenous, whereas the spreadablity of gels increased. Antibacterial evaluation showed that formula I give the best effectiveness with 16,11 mm zone of inhibition against P. acnes and 14,00 mm against S.epidermidis.

Co-Authors Achmad Fudholi Achmad Fudholi Adelita Ahyanurri Agvina Felicia Esperanza Andhi FAHRURROJI Apridamayanti, Pratiwi Bambang WIJIANTO Damanik, Virna Helena Defiga Kasrin Dermawan, Abdurraafi Maududi Diah Ismarani Diah Ismarani Diah Ismarani, Diah Fajar Nugraha Fajar Nugraha Fajriaty, Inarah Felisitas Feli Fitri, Aulia Kemala Hadi Kurniawan Harum Nadyanti Usman Hervianto, Willy Indri Kusharyanti Isnindar Isnindar Istiqomah, Rifqi Luliana, Sri Melania Niken Safira Nera Umilia Purwanti, Nera Umilia Novia Novia Pratiwi Apridamayanti Pratiwi Apridamayanti Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Rafika Sari Rafika Sari Rafika Sari Ronny Martien Ronny Martien Safrilla Anggraeni Shinta Nia Putri Shoma Rizkifani Siti Nani Nurbaeti Sri Wahdaningsih Suhartaty, Lindy Suwidjiyo Pramono Suwidjiyo Pramono SYF. OCTY NOVY FISSY Tendianus, Tendianus Ulfa Sri Mandasari Utami, Amanda Yanasari Wendy Wendy Wijianto, Bambang Wijianto Willy Hervianto Yulnalia Mariella Delavega Yuswar, Muhammad Akib

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