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All Journal Majalah Obat Tradisional
Erna Prawita Setyowati
Deprtment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
Health Professions Medicine & Pharmacology Public Health

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Penares sp sponge from Menjangan Island-water West Bali National Park: Isolation of Cytotoxic Compounds Erna Prawita Setyowati; Sudarsono Sudarsono; Retno Murwanti
Majalah Obat Tradisional Vol 22, No 3 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (909.182 KB) | DOI: 10.22146/mot.31547

Abstract

Sponges are multicellular animals which have cytotoxic compounds. In this study, isolation and cytotoxic activity of Penares sp sponge from Menjangan island-water West Bali National Park have been carried out. The results showed that chloroform extract and GF V Penares sp fraction were toxic according to Brine Shrimp Lethality Test method (each 85% and 63.3% mortality at 25μg/mL concentration). The isolation result of GF V fraction was obtained a compound (Spot 4) that is active as cytotoxic agent against T47D cells (IC50 of 12.7 ug/mL). Spot 4 is a terpenoid compound which has conjugated double bonds.
Co-Authors Retno Murwanti Sudarsono Sudarsono