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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi Statistika Indonesian Journal of Cancer Chemoprevention Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Biotechnology Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL BIOLOGI INDONESIA The Indonesian Biomedical Journal Jurnal Farmasi Sains dan Komunitas Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Majalah Farmaseutik Indonesian Journal of Chemistry Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline INTEGRITAS : Jurnal Pengabdian Jurnal Farmasi Journal of Community Development Populer: Jurnal Penelitian Mahasiswa Jurnal Kedokteran Hewan Journal of Food and Pharmaceutical Sciences Agri Analytics Journal Jurnal Medika: Medika Indonesian Journal of Pharmacology and Therapy
Retno Murwanti
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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POTENSI BIJI LABU KUNING SEBAGAI AGEN FITOESTROGEN PADA WANITA POST MENSTRUAL Lestari, Beni; Hanif, Naisbitt Iman; Anggarany, Ariska Deffy; Ziyad, Thoriq; Walidah, Ziana; Murwanti, Retno
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.169 KB)

Abstract

Osteoporosis and hypercholesterolemia are prevalent condition in menopausal women. The common therapy to prevent the estrogen degrading condition is Hormone Replacement Therapy (HRT). However, HRT possessed various risks. Curcubita pepo L. seed (pumpkin seed) contains lignan secoisolariciresinol and lariciresinol which exhibit estrogenic effect. The aim of this study is to determine the estrogenic effect of Ethanolic Extract of Pumpkin Seeds (EEPS) through in silico and in vivo study. In silico study were conducted by molecular docking of lignan which is secoisolariciresinol and lariciresinol with Estrogen Receptor (ERα and Erβ). In vivo study conducted by using ovariectomized Sprague dawley female rats as a model of postmenopausal women. Blood lipid profile, bone density, and uterine weight were assayed after thirty days. Molecular docking score of secoisolariciresinol and lariciresinol were similar to estradiol. In vivo study found that EEPS increase bone density and uterine weight percentage while also improve the blood profile. In conclusion, these result showed that EEPS is potential to be developed as an osteoporosis and hypercholesterolemia prevention agent. Keywords:  Lime peel, Limonene, Aromatic candles, Repellent
Chemopreventive effect of ethanolic extract of Gynura procumbens (Lour), Merr on the carcinogenesis of Rat breast cancer development Meiyanto, Edy; Susilowati, Sri; Tasminatun, Sri; Murwanti, Retno; ., Sugiyanto
INDONESIAN JOURNAL OF PHARMACY Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.982 KB) | DOI: 10.14499/indonesianjpharm0iss0pp154-161

Abstract

Gynura procumbens (Lour) Merr., empirically, used to prevent cancer development and has been proven to be able to suppress lung cancer development. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBA-induced breast cancer development. Sprague Dawly Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 3 levels of doses, namely 250, 500, and 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, 500, and 750 mg/kgBW reduced tumor incidence by 60%, 30 %, and 20 % respectively. The doses of 500 and 750 mg/kgBW exhibited strong suppression of tumor multiplicity, where as the dose of 250 performed less potential suppression. In conclusion, ethanolic extract of G. procumbens performs chemopreventive effect to suppress breast cancer development at the dose of 250 mg/kgBW.Key words : chemopreventive, Gynura procumbens (Lour) Merr, breast cancer.
Efek Penghambatan Terhadap Pertumbuhan Tumor Paru dan Uji Ketoksikan Akut Ekstrak Kapsul Chang Sheuw Tian Ran Ling Yao Pada Mencit (Mus musculus) dan Tikus (Ratus tanezumi) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.692 KB) | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It’s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
Physical and Chemical Properties of Native and Fully Pregelatinized Cassava Starch (Manihot esculenta Crantz) Dewantara Putra, I Gusti Ngurah Agung; Murwanti, Retno; Rohman, Abdul; Sulaiman, T.N Saifullah
Indonesian Journal of Pharmacy Vol 29 No 3, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1325.919 KB) | DOI: 10.14499/indonesianjpharm29iss3pp145

Abstract

Starch is widely used as an excipient in pharmaceutical formulations because it is inert and it can be mixed with drugs without any chemical reactions. This study was aimed to develop and to characterize the physical and chemical properties of cassava starch fully pregelatinized (CSFP) and native cassava starch (Manihot esculenta Crantz) (NCS). Organoleptic properties, pH, ash content, shrink drying, macroscopic and microscopic analyses, amylose and amylopectin content, bulk and tapped density, the angle of repose and flow rate were physically evaluated for both type of cassava starch. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDS), and differential scanning calorimetry (DSC) were used to characterize and evaluate the chemical properties of the CSFP and NCS. The results of this study indicate that CSFP exhibited different values of those determined parameters compared to that of NCS organoleptic properties i.e, pH, viscosity, ash content, shrink drying, macroscopic and microscopic analyses, amylose and amylopectin content, bulk and tapped density, angle of repose and flow rate. The measurement results with DSC obtained Tg at NCS of 68.18oC while in CSFP there is no Tg because cassava starch (CS) is fully gelatinized. In conclusion, CSFP as a good profile starch contained a higher amount of amylose with larger particle size and good particle density and viscosity than the natural starch and improve its flow properties and compactibility. CSFP had a noticeable effect on fragility, hardness, disintegration time and percentage of drug release from the tablets produced, that can be developed as a pharmaceutical excipient in development of solid dosage forms  (sustain release). 
PENGARUH EKSTRAK RIMPANG TEMU PUTIH (Curcuma zedoaria Rosc.) TERHADAP KARSINOGENESIS PARU YANG DIINDUKSI OLEH BENZO[]PIREN Murwanti, Retno; Meiyanto, Edy; Nurrochmad, Arief; Alexxander, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 3, No 2 (2006)
Publisher : Indonesian Research Gateway

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Abstract

This experiment was aimed to investigate the influence of Curcuma zedoaria Rosc. ethanol extract on the growth of benzo[a]pyrene-induced lung tumor in male Balb/c mice. New born miced were induced with 0,2 mmol, 0,4 mmol, and 0,8 mmol benzo[a]pyrene intraperitoneally at day 1, 8, and 15 after born. On day 25 after born, the male mice were distributed into 5 groups. Group 1, 2 and 3 were treated with Curcuma zedoaria Rosc. ethanol extract consecutively 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW. Group 4 was treated with DMSO (solvent) and group 5 was B[a]P induced tumor positive control.  Mice were sacrificed at 4 month age, and lung were collected for examination of tumor nodules macroscopic and microscopically. Intensity of carcinogenicity was expressed as number of  tumor bearing mice in each group, and number of of tumor nodules per mouse lung. From the result it was concluded that  Curcuma zedoaria Rosc. ethanol extract dose 250-750 mg/kgBW can inhibit the growth of lung tumor in male mice up to 18,75%. ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol rimpang temu putih terhadap pertumbuhan  tumor paru pada mencit jantan galur Balb/c yang diinduksi benzo[a]piren. Anak mencit yang baru lahir diinduksi secara intraperitoneal dengan benzo[a]piren pada hari ke-1, ke-8, dan ke-15 setelah kelahiran dengan dosis masing-masing sebesar 0,2 mmol, o,4 mmol, dan 0,8 mmol. Pada hari ke-25 setelah kelahiran, mencit jantan dibagi menjadi 5 kelompok, kelompok pertama sampai ke-3 diberi ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB, kelompok  ke-4 diberi pelarut DMSO dan kelompok ke-5 sebagai kelompok kontrol positif kanker B[a]P. Mencit dikorbanan pada umur 4 bulan dan diambil organ paru, untuk diamati adanya nodul tumor secara makroskopis dan mokroskopis. Intensitas karsinogenesitas dinyatakan sebagai jumlah mencit yang terkena tumor paru dalam setiap kelompok, dan jumlah tumor per mencit dalam setiap organ paru. Analisis statistik yang digunakan adalah analisis Non parametrik Test (Kruskal-Wallis Test) dan diteruskan dengan Mann-Whitney Test. Dari penelitian ini diambil kesimpulan bahwa ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan dosis 750 mg/kgBB mampu menghambat pertumbuhan tumor paru pada mencit jantan pada fase post inisiasi dengan prosentase penghambatan berturut-turut 28,5%, 83,5%, dan 18,75%.
PENGARUH EKSTRAK RIMPANG TEMU PUTIH (Curcuma zedoaria Rosc.) TERHADAP KARSINOGENESIS PARU YANG DIINDUKSI OLEH BENZO[]PIREN Murwanti, Retno; Meiyanto, Edy; Nurrochmad, Arief; Alexxander, .
Jurnal Farmasi Indonesia Vol 3, No 2 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i2.71

Abstract

This experiment was aimed to investigate the influence of Curcuma zedoaria Rosc. ethanol extract on the growth of benzo[a]pyrene-induced lung tumor in male Balb/c mice. New born miced were induced with 0,2 mmol, 0,4 mmol, and 0,8 mmol benzo[a]pyrene intraperitoneally at day 1, 8, and 15 after born. On day 25 after born, the male mice were distributed into 5 groups. Group 1, 2 and 3 were treated with Curcuma zedoaria Rosc. ethanol extract consecutively 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW. Group 4 was treated with DMSO (solvent) and group 5 was B[a]P induced tumor positive control.  Mice were sacrificed at 4 month age, and lung were collected for examination of tumor nodules macroscopic and microscopically. Intensity of carcinogenicity was expressed as number of  tumor bearing mice in each group, and number of of tumor nodules per mouse lung. From the result it was concluded that  Curcuma zedoaria Rosc. ethanol extract dose 250-750 mg/kgBW can inhibit the growth of lung tumor in male mice up to 18,75%. ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol rimpang temu putih terhadap pertumbuhan  tumor paru pada mencit jantan galur Balb/c yang diinduksi benzo[a]piren. Anak mencit yang baru lahir diinduksi secara intraperitoneal dengan benzo[a]piren pada hari ke-1, ke-8, dan ke-15 setelah kelahiran dengan dosis masing-masing sebesar 0,2 mmol, o,4 mmol, dan 0,8 mmol. Pada hari ke-25 setelah kelahiran, mencit jantan dibagi menjadi 5 kelompok, kelompok pertama sampai ke-3 diberi ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB, kelompok  ke-4 diberi pelarut DMSO dan kelompok ke-5 sebagai kelompok kontrol positif kanker B[a]P. Mencit dikorbanan pada umur 4 bulan dan diambil organ paru, untuk diamati adanya nodul tumor secara makroskopis dan mokroskopis. Intensitas karsinogenesitas dinyatakan sebagai jumlah mencit yang terkena tumor paru dalam setiap kelompok, dan jumlah tumor per mencit dalam setiap organ paru. Analisis statistik yang digunakan adalah analisis Non parametrik Test (Kruskal-Wallis Test) dan diteruskan dengan Mann-Whitney Test. Dari penelitian ini diambil kesimpulan bahwa ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan dosis 750 mg/kgBB mampu menghambat pertumbuhan tumor paru pada mencit jantan pada fase post inisiasi dengan prosentase penghambatan berturut-turut 28,5%, 83,5%, dan 18,75%.
EFEK PENGHAMBATAN TERHADAP PERTUMBUHAN TUMOR PARU DAN UJI KETOKSIKAN AKUT EKSTRAK KAPSUL CHANG SHEUW TIAN RAN LING YAO PADA MENCIT (MUS MUSCULUS) DAN TIKUS (RATUS TANEZUMI) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It?s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
KETOKSIKAN AKUT TABLET EFFERVESCENT DARI EKSTRAK DAUN SIRIH (Piper betle L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Farida Hayati; Retno Murwanti; Dwi Brilyani Sandy
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTA research on acute toxicity of effervescent tablet from Piper betle leaf extractum on wistaralbino male rats was done. This research aimed to determine acute toxicity potential ofeffervescent tablet from piper betle leaf extractum, evaluated clinical symptom that perhaps occurdue to the giving of effervescent tablet, single dosage orally on 24 hours to 15 days observation.The research uses male rats, which are divided into 5 groups. Group I was negative control withaquadest. Group II was given sample with 0,38 g/kgBW dosage. Then, succesively group III with1,03 g/kgBW dosage, group IV with 2,79 g/kgBW dosage and group V was given test sample withhighest dosage, that was 7,50 g/kgBW dosage. On the basis of data analysis result having beenperformed both quantitively and qualitatively, it could be said that in general, the giving ofeffervescent tablet from Piper betle leaf extractum single dosage orally on male rats from 0,38g/kgBW dosage to highest level (7,50 g/kgBW) or approximately 19,74 times of therapy dosage,didn’t cause toxic effect. It didn’t cause mortality on research animal. So we can determine thequasi LD50, that was bigger than 7,50 g/kgBW, according to Loomis criteria (1978), that acutetoxicity potential of effervescent tablet from piper betle extractum was practically not toxic category.Key words: acute toxicity, effervescent tablet, Piper betle
KEAMANAN PEMBERIAN BERULANG EKSTRAK KANGKUNG DARAT (Ipomoea reptans,Poir) TERSTANDAR TERHADAP FUNGSI GINJAL DAN HEPAR MENCIT BETINA Farida Hayati; Retno Murwanti; Ginna Zabrina
Jurnal Ilmiah Farmasi Vol. 10 No. 1 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss1.art1

Abstract

Kangkung darat terbukti memiliki aktifitas antihiperglikemia pada mencit betina galur swiss yang diinduksi streptozotosin. Penelitian ini dilakukan untuk mendapatkan kajian keamanan pemberian berulang ekstrak kangkung darat terstandar terhadap fungsi ginjal dan hepar pada mencit betina. Dua puluh hewan uji dibagi ke dalam 4 kelompok, yaitu kelompok kontrol (akuades 10 ml/ kg), dosis I (ekstrak etanolik kangkung darat 480 mg/ kg), dosis II (ekstrak etanolik kangkung darat 759 mg/ kg), dan  dosis III (ekstrak etanolik kangkung darat 1200 mg/ kg). Ekstrak etanolik kangkung darat diberikan 1 kali sehari secara p.o. selama 14 hari. Pengamatan gejala toksik dilakukan selama 3 jam setelah pemberian senyawa uji. Kelompok dosis 1200 mg/ kg mengalami efek sedasi, konstipasi, dan feses berwarna hitam selama pemberian ekstrak etanolik kangkung darat terstandar, sedangkan kelompok lainnya tidak mengalami gejala toksik. Data berat badan, pemeriksaan ALT, dan pemeriksaan AST dianalisis secara statistik. Berat badan rata-rata hewan uji kelompok dosis 759 mg/ kg mengalami penurunan yang paling banyak dibandingkan kelompok lainnya dan berbeda signifikan dengan kelompok kontrol dari hasil analisis statistik. Kadar AST dan ALT mengalami peningkatan setelah pemberian berulang ekstrak etanolik kangkung darat selama 14 hari, dari hasil analisis statistik kadar ALT dan AST kelompok dosis 759 mg/ kg dan dosis 1200 mg/ kg berbeda signifikan dengan kelompok kontrol (p<0,05). Hasil histopatologi organ ginjal dan hepar hewan uji setelah pemberian berulang ekstrak etanolik kangkung darat terstandar selama 14 hari menunjukkan tidak adanya perubahan yang membahayakan pada organ.
KETOKSIKAN AKUT TABLET EFFERVESCENT DARI EKSTRAK DAUM SIRIH ( Piper betle L.) PADA TIKUS PUTIH BETINA GALUR WISTAR Farida Hayati; Retno Murwanti; Wahyu Utaminingrum
Jurnal Ilmiah Farmasi Vol. 4 No. 1 (2007)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A research on acute toxicity of effervescent tablet from Piper betle leaf extractum on wistar albino female rats was done. This research aimed to determine acute toxicity potential of effervescent tablet from piper betle leaf extractum, evaluated clinical symptom that perhaps occur due to the giving of effervescent tablet, single dosage orally on 24 hours to 15 days observation. The research uses female rats, which are divided into 5 groups. Group I was negative control with aquadest. Group II was given sample with 0,38 g/kgBW dosage. Then, succesively group III with 1,03 g/kgBW dosage, group IV with 2,79 g/kgBW dosage and group V was given test sample with highest dosage, that was 7,50 g/kgBW dosage. On the basis of data analysis result having been performed both quantitively and qualitatively, it could be said that in general, the giving of effervescent tablet from Piper betle leaf extractum single dosage orally on female rats from 0,38 g/kgBW dosage to highest level (7,50 g/kgBW) or approximately 19,74 times of therapy dosage, didn't cause toxic effect which causing damage on lung, liver, kidney, heart, spleen, stomach and intestine. It didn't cause mortality on research animal. So we can determine the quasi LD^, that was bigger than 7,50 g/kgBW, according to Loomis criteria (1978), that acute toxicity potential of effervescent tablet from piper betle extractum was practically not toxic category. Thus based on ANOVA result with 95 % significance level, it could be said that the giving of effervescent tablet from piper betle leaf extractum didn't show significant differences to average body weight changes and organ weight.
Co-Authors Abdul Rohman Adam Hermawan Agung Endro Nugroho Agung Endro Nugroho Ahmad Marzuki Aisyah Nur Khasanah Alexxander, . Alexxander, . Alifia Brilliani Hidayah Amalia, Latifa Anami Riastri Andayana Puspitasari Gani Andayana Puspitasari Gani Andayana Puspitasari Gani Anselma Ivanawati Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Rahman Hakim Arifka, Vigha Ilmanafi Ariska Deffy Anggarany, Ariska Deffy Asri Mega Putri Azizah Amin Azizah, Ulfah Laily Azmi Rahmadani Bambang Sulistiyo Ari Sudarmanto Bani Adlina Shabrina Bayu Irawan, Muhamad Bayu Prio Septiantoro Beni Lestari Budastra, Wayan Cintya Ganes Cindy Puspita Sari Devina Martina Devita Anggraeni Devyanto Hadi Triutomo Dhania Novitasari Dhirgo Adji Diana Rachma Ningsih Dwi Brilyani Sandy Dwi Salim, Rozin Dyah Afritasari Dyah Aryani Perwitasari Dyaningtyas Dewi Pamungkas Putri Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Effendi, Adha Maula Erna Prawita Setyowati Erna Prawita Setyowati Fikriansyah Fikriansyah Fita Rahmawati Fitri, Dafina Aisya Fitriana Hayyu Arifah Gagas Pradani Nur Ilmawati Gani, Andayana Puspitasari Ghea Rachella Tiffany Ginna Zabrina Hayati, Farida Hendri Wasito Herwandhani Putri Hilyatul Fadliyah I Gusti Ngurah Agung Dewantara Putra Ida Ayu Putu Sri Widnyani Idlohatud Dilalah Ika Puspita Sari Illian, Didi Nurhadi Imono Argo Donatus, Imono Argo Iren Wati Siahaan Jenie, Riris Istighfari Juang Juansa Khafi, Muhammad Kustanto, Satya Prima Layung Sekar Sih Wikanthi Ledi, Ledi Klarismawati Lodyta Nawang Tika lubis, muhammad fauzan Lukman Hakim Luthfiyyah, Annisa Tiara Maharani, Astrid Martien , Ronny Mentari Widiastuti Miftahus Sa&#039;adah Muharom, Luthfi Ali Mustofa Mustofa Naisbitt Iman Hanif, Naisbitt Iman Nanda Saifullah Sulaiman, Teuku Ngurah Agung Dewantara Putra, I Gusti Nindi Wulandari Nindya Budiana Putri Nindya Budiana Putri Ningsih, Diana Rachma Norita Citra Yuliarti, Norita Citra Nunung Yuniarti Nuqya Ashfannada Nursani, Rabila Nurul Mukhlisa Pratiwi, Rima Dwi Prawitasari, Saptya Prisnu Tirtanirmala Probowulan, Diyah Purnomo, Kurnia Rahayu Purwantiningsih Purwantiningsih Rahmawati, Desty Restia Rahmawaty Rachmady Rahmayani, Almira Retno S. Sudibyo Retno Sunarminingsih Sudibyo Riandari , Teti Mariam Rima Munawaroh Riris Istighfari Jenie Risa Umari Yuli Aliviyanti Ritmaleni, Ritmaleni Rizkita, Anggraini Ihza Rohmad Yudi Utomo Rohman, Abdul Rommy Sagala, Reynelda Juliani Sardjiman . Sari Haryanti Sari Haryanti Sari, Laras Ratna Shofa Annur Siswadi Siswadi Siti Nur Annisa Sri Susilowati Sri Tasminatun Sri Wahdaningsih Subagus Wahyuono Sudarsono Sudarsono Sugeng Riyanto Sugiyanto . Sugiyanto . Sulaiman, T.N Saifullah Sumaiyah, Sumaiyah Susi Ari Kristina Suwijiyo Pramono Suwijiyo Pramono Tampubolon, Keshia Thoriq Ziyad, Thoriq Triana Candraningrum Triana Hertiani Triawan Adi Cahyanto Ulfa Afrinurfadhilah Darojati Wahyu Utaminingrum Widya Leontin Susanti Wulandari, Febri Yance Anas Yoce Aprianto Yundari, Yundari Zahrotul Ulum Ziana Walidah, Ziana