Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

p-Index From 2020 - 2025

0.562

P-Index

This Author published in this journals

All Journal Folia Medica Indonesiana Majalah Obat Tradisional

Paulus Liben

Departemen Ilmu Faal, Fakultas Kedokteran, Universitas Airlangga Surabaya

Author-ID : 3038573

Health Professions Medicine & Pharmacology Public Health Other

Published : 4 Documents Claim Missing Document

Claim Missing Document

Articles

Apium graveolens Prevents Intrauterine Growth Restriction via Suppression of Antiangiogenic Factor Production Exma Mu'tatal Hikmah; Paulus Liben; Widjiati Widjiati
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Preeclampsia is the worldwide leading cause of fetomaternal morbidity and mortality which involves the placental dysfunction. A poor placentation and formed of non-dilated spiral artery caused utero-placental circulation insufficiency, resulted in inadequate supply of nutrients and oxygen to support normal aerobic growth of the fetus. Apium graveolens or celery has been widely known as antioxidant, antiinflammation and antihypertensive with flavonoid-apigenin as main active compound. Apigenin can inhibit TNF-α, HIF-1α and nitric oxide blocking as major pathophysiological pathway of preeclampsia. This study was aimed to find how the Apium graveolens can improve intrauterine growth and its correlation with suppression of anti-angiogenic factor sFlt-1 in anti-Qa2 preeclampsia animal model. Twenty female BALB/c Mus musculus were divided into 4 groups: control, anti-Qa2 and anti-Qa2 with 500 and 1000 mg/kgBW celery herbs extract. The fetal weights and lengths, placental weights and serum sFlt-1 levels were measured and analyzed with One Way ANOVA and further tested with Least Significance Difference in 95% confidence interval. The result showed a difference between control and treatments group (p≤0.05) with 1000 mg/kgBW significantly increase intrauterine growth and decrease sFlt-1, then there is a negative correlation between intrauterine weight and serum sFlt-1. This study suggests that celery herbs extract (CHE) has an apigenin-flavonoid compound which can prevent intrauterine growth restriction (IUGR) via suppression of antiangiogenic factor production in preeclampsia mice model.

Low and Moderate Intensity Exercise Decreased Body Fat and Increased Free Fatty Acid in Overweight Women Rizky Sota Dyaksa; Paulus Liben; Edy Mintarto
Folia Medica Indonesiana Vol. 57 No. 4 (2021): December
Publisher : Universitas Airlangga

Highlight:Aerobic exercise was reduced body fat and increased free fatty acids.LICT and MICT decreased body fat and increased free fatty acids. Abstract:Overweight is fat imbalances can affect the health. It is one of the problems in many countries, especially Indonesia recorded an increase case in 2007 (8.8%) to 2013 (13.5%). Overweight categorized by 25-30 kg/m2 body mass index in units (Organization 2018). Figures overweight can be pressed to provide some treatments, such as aerobics sports activities. This study aimed to determine the effect of Continuous Low Intensity Training (LICT) and Moderate Intensity Continuous Training (MICT) to decrease body fat content (FM) and increase in free fatty acids (FFA) in overweight women. 18 female subjects completed the study 4X/week exercise LICT or MICT for 5 weeks. LICT and MICT performed for 30 minutes with an additional 5 minutes warm-up and 5 minutes of cooling down with LICT intensity of 60%-70% and MICT 70%-80% of maximum HR where both types of exercise using ergo cycle while measurement FM and FFA were measured before and after practice. LICT occurred decreasing in body fat and increasing in free fatty acids that significant pre and post LICT (p < 0.05). MICT occurred decreasing in body fat and increasing in free fatty acids that significant pre and post MICT (p<0.05). In the second comparison group (LICT and MICT) were decline against body fat and an increased in free fatty acids between workouts Low-Intensity Continuous Training (LICT) greater tendency than Moderate-Intensity Continuous Training (MICT) with delta FM (p = 0.120) and delta FFA (p=0.131) in which the value is >0.05. LICT and MICT was increase while body fat was decreased. The results of a comparison test occur list downward trend in body fat while in free fatty acids was increased.

Mechanism of Physical Exercise on Lowering Levels of C-Reactive Protein (CRP) in Overweight and Obese Muchammad Rif’at Fawaid As’ad; Paulus Liben; Lilik Herawati
Folia Medica Indonesiana Vol. 57 No. 1 (2021): March
Publisher : Universitas Airlangga

Cases of overweight and obesity in the world increased continuously. In 2016, obesity increased by 3% in men and 6% in women compared to 1975. Overweight cases also increased by 20% in men and 23% in women compared to 1975. Overweight and obesity have been linked to an increase in adipose tissue in the body. Increased adipose tissue associated with inflammation, which one of its characteristics is an increase levels of C - Reactive Protein (CRP). This article aim is to describe the mechanism of physical exercise to diminish CRP level in overweight and obesity. Adipose tissue produces and releases various pro-inflammatory and anti-inflammatory factors such as leptin, adiponectin, resistin, TNF-α, IL-6, MCP-1 and CRP. One of the prevention and treatment of inflammatory for overweight and obesity cases is to do physical exercise. In cases of overweight and obesity, the physical exercise aims to increase energy expenditure. Physical exercise decreases the volume and amount of adipose and pre-adipose tissue as well as the number of endothelial cells and macrophages in adipose that contain pro-inflammation such as IL-1, TNF-α, CRP, serum amyloid protein (SAA), and cytokines. Physical exercise rises anti-inflammatory properties such as IL-10, IL-1ra which play a role in inhibiting the transduction of IL-1β signals and inhibiting TNF-α synthesis. Physical exercise also amplifies antioxidant enzymes such as SOD and GPX. The antioxidants play a role in fighting free radicals to reduce inflammation.

Four Weeks Exercise in Vary Intensities Reduce More Inguinal Fat Than Perigonadal Fat in Mice Ahmad Rukhani Lutfi; Paulus Liben; Lilik Herawati
Folia Medica Indonesiana Vol. 57 No. 2 (2021): June
Publisher : Universitas Airlangga

Staphylococcus aureus (S. aureus) is the most common pathogen in humans that causes various infections. A variety of infections due to S. aureus are related to virulence factors, one of which is Toxic Shock Syndrome Toxin-1 (TSST-1) as the main cause of Toxic Shock Syndrome (TSS). This study aimed to explore the genetic pattern of the tsst-1 genes among MSSA and MRSA from clinical isolates of patients at Dr. Soetomo General Academic Hospital, Surabaya-Indonesia. This study performed a PCR test on 106 clinical samples of S. aureus isolated to determine the presence of the tsst-1 genes; subsequently, this study also performed phylogenetic analysis. The positive tsst-1 genes were found in 3 (5.7%) MSSA isolates and 2 (3.8%) MRSA isolates from 106 samples that were divided into 53 MSSA isolated and 53 MRSA isolates. There was no significant difference between the tsst-1 genes on both the MSSA and MRSA bacteria (p = 0.648). The positive tsst-1 genes were found in 1 (4.5%) of pus specimens and 2 (16.7%) of blood specimens from MSSA isolates. However, the positive tsst-1 genes were found in neither sputum nor urine specimens. The genes were found in 2 (16.7%) of blood specimens from MRSA isolates. Based on the phylogenetic tree, Indonesian tsst-1 isolated belonged to the same clade as Japan, Iran, Iraq, India, Egypt, and the United Kingdom. The prevalence of tsst-1 genes of both MSSA and MRSA from clinical isolates in Dr. Soetomo General Academic Hospital Surabaya was 5.7% and 3.8%, respectively. The tsst-1 genes of Surabaya-Indonesia, Japan, Iran, Iraq, India, Egypt, and the United Kingdom belonged to the same clade.

Co-Authors Ahmad Rukhani Lutfi Andy Anthony Parung Bambang Herwanto Edy Mintarto Exma Mu'tatal Hikmah HERAWATI, LILIK Muchammad Rif’at Fawaid As’ad Rizky Sota Dyaksa Widjiati Widjiati

Title

Found 4 Documents
Search

Abstract

Abstract

Abstract

Abstract

Title Search

Found 4 Documents Search

Abstract

Abstract

Abstract

Abstract

Title

Found 4 Documents
Search