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Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan Mude, Serafin Anastasia; Tamayanti, Wahyu Dewi; Liben, Paulus
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.) pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji (Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3 masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB; dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6 g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah makanan dan berat badan tikus.

Apium graveolens Prevents Intrauterine Growth Restriction via Suppression of Antiangiogenic Factor Production Exma Mu'tatal Hikmah; Paulus Liben; Widjiati Widjiati
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Preeclampsia is the worldwide leading cause of fetomaternal morbidity and mortality which involves the placental dysfunction. A poor placentation and formed of non-dilated spiral artery caused utero-placental circulation insufficiency, resulted in inadequate supply of nutrients and oxygen to support normal aerobic growth of the fetus. Apium graveolens or celery has been widely known as antioxidant, antiinflammation and antihypertensive with flavonoid-apigenin as main active compound. Apigenin can inhibit TNF-α, HIF-1α and nitric oxide blocking as major pathophysiological pathway of preeclampsia. This study was aimed to find how the Apium graveolens can improve intrauterine growth and its correlation with suppression of anti-angiogenic factor sFlt-1 in anti-Qa2 preeclampsia animal model. Twenty female BALB/c Mus musculus were divided into 4 groups: control, anti-Qa2 and anti-Qa2 with 500 and 1000 mg/kgBW celery herbs extract. The fetal weights and lengths, placental weights and serum sFlt-1 levels were measured and analyzed with One Way ANOVA and further tested with Least Significance Difference in 95% confidence interval. The result showed a difference between control and treatments group (p≤0.05) with 1000 mg/kgBW significantly increase intrauterine growth and decrease sFlt-1, then there is a negative correlation between intrauterine weight and serum sFlt-1. This study suggests that celery herbs extract (CHE) has an apigenin-flavonoid compound which can prevent intrauterine growth restriction (IUGR) via suppression of antiangiogenic factor production in preeclampsia mice model.

PENGARUH PERASAN UMBI AKAR LOBAK (Rhapanus sativus L) TERHADAP PENINGKATAN KADAR PROLAKTIN DALAM DARAH MENCIT (Mus musculus) BETINA Mas Loegito; Paulus Liben; Thin Soedarti
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 11 No 2 (2006): June 2006
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/383

The objective of this research was to prove that the administration of radish tuber extract (Rhapanus sativus L) to female mice (Mus musculus) might increase blood prolactin level. This was an experimental research using complete randomized design by involving three treatment groups and three control group, each with five replications. Materials consisted of radish tuber extract and 30 female mice of 8 weeks old divided into 6 groups, i.e., control groups of C1, C2, and C3, and treatment groups of T1, T2, and T3. C1, C2, and C3 groups were given water of 1 × 0.5 cc/day per oral, 2 × 0.5 cc/day, and 3 × 0.5 cc/day respectively. Treatment groups of T1, T2, and T3 were given radish tuber extract of respectively 1 × 0.5 cc/day per oral, 2 × 0.5 cc/day, and 1 × 0.5 cc/day. Treatment was carried out for 21 days. Blood was subsequently taken from those rats for blood prolactin level. Data were analyzed using Anove test. If the results indicated significant difference of 95% (p = 0.05), the analysis was continued with LSD. The conclusions of this experiment is the administration of radish tuber extract per oral may result in the increase of blood prolactin level.

Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan Mude, Serafin Anastasia; Tamayanti, Wahyu Dewi; Liben, Paulus
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.701

Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.) pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji (Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3 masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB; dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6 g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah makanan dan berat badan tikus.

TERDAPAT PERBEDAAN PENGARUH CIRCUIT BODY WEIGHT TRAINING (CBWT) SUBMAKSIMAL TERHADAP PENURUNAN PERSENTASE LEMAK TUBUH, LEMAK SUBKUTAN DAN MENINGKATKAN OTOT SKELETAL Pambudi, A. Agam Haris; Liben, Paulus; Rejeki, Purwo Sri
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 8, No 3 (2020): EDITION NOVEMBER 2020
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v8i3.1294

Physical activity with moderate intensity can be implemented with various types of exercise, including multiple movements done in turns which take a bodyweight as a training load known as the circuit body weight training (CBWT). The purpose of this research to prove influence CBWT moderate intensity to the percentage of the body fat, subcutaneous fat and muscles skeletal a person trained and untrained. This is research experimental with the methods pretest-posttest design. 20 people women aged 18 to 23 years was obtained using proportionate stratified random sampling. Consisting of K1 10 people trained and K2 10 people untrained. Done the measurement of the percentage of the body fat, subcutaneous fat and muscles skeletal use weight body composition monitor model HBF-375 Karada scan. The subject is given the treatment CBWT moderate intensity (64-76% heart rate maximum) for 30 menit, after which the measurement was done again 5 minutes after treatment. The data were analyzed using the SPSS statistical tests with paired t-test and the continued independent t-test. Body fat pre K1 mean ∆ (0,53%±0,28), and K2 mean ∆ (0,92%±0,69), the value of p = 0,119 (p

AKTIVITAS FISIK AKUT INTERVAL DAN KONTINYU INTENSITAS MODERAT TIDAK DAPAT MENURUNKAN KADAR BIOMARKER RESORPSI TULANG CTx Triardhana, Yanuar Alfan; Sari, Gadis Meinar; Liben, Paulus
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 2 (2021): EDITION JULY 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i2.1510

Physical activity will affect the bone remodeling process and have an impact on bone health. Physical activity would activate osteoblasts and precursor through lane HPA Axis to start the process of bone remodeling. When the process of remodeling of bone occurs there are molecules of collagen which is released into the circulation, i.e. CTx (osteoclast marker). The aim of this study to showing effect of acute continuous and interval physical activity with moderate intensity on CTx. This research was using the type of research field experimental by using the pretest-posttest design. Sixteen adult male was selected on this study and devided into 2 with 8 people every group. Blood sample was taken before and 1 hour after the physical activity. The results obtained showed the acute effect of continuous physical activity with moderate intensity to CTx with a mean pretest 0,93 ± 0,566 posttest 0,559 ± 0,398 ng/mL (p = 0.173 0.05), acute effect of moderate intensity interval physical activity on CTx with the mean pretest 0,451 ± 0,302 posttest 0,524 ± 0,284 ng/mL (p = 0.693 0.05). From this study can be concluded that there was no effect of acute continuous and interval physical activity with moderate intensity on CTx.

AKTIVITAS FISIK AKUT INTENSITAS TINGGI MEMPERBAIKI KADAR IL-6 OTOT MODEL MENCIT DIABETES MELITUS Purwoto, Septyaningrum Putri; Purwanto, Bambang; Liben, Paulus
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 8, No 3 (2020): EDITION NOVEMBER 2020
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v8i3.1299

Diabetes mellitus is a metabolic disease whose prevalence continues to increase. Diabetes mellitus sufferers are advised to do lifestyle interventions in the form of physical activity. Physical activity provides benefits for diabetics, through the autocrine response of muscles to release IL-6 for muscle repair. The purpose of this study was to determine the appropriate intensity of physical activity against muscle IL-6 in diabetic mice. The subjects in this study were male mice (balb / c) weighing 20-30 grams. This study was divided into 4 groups. The treatment in the form of treadmill activity is carried out once with heating for 5 minutes and core for 30 minutes. This study used a True Experimental research design using a Random Control Group Posttest-Only Design research design. The variable measured in this study was muscle IL-6, namely the calf muscle (gastrocnemious and soleus muscles) of the left and right legs of each subject 24 hours after acute physical activity. Acute physical activity causes the release of interleukin-6 by myofibers. Based on the analysis results showed that there was a significant effect of low, medium, and high intensity acute physical activity on muscle IL-6 levels (p = 0.05). In addition, it also showed that the highest average muscle IL-6 level was the high intensity treatment group with a value of 325.17267 mg / dL. These results prove that high-intensity acute physical activity improves IL-6 levels in the muscle muscle model of diabetes mellitus mice.

Four Weeks Exercise in Vary Intensities Reduce More Inguinal Fat Than Perigonadal Fat in Mice Lutfi, Ahmad Rukhani; Liben, Paulus; Herawati, Lilik
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Staphylococcus aureus (S. aureus) is the most common pathogen in humans that causes various infections. A variety of infections due to S. aureus are related to virulence factors, one of which is Toxic Shock Syndrome Toxin-1 (TSST-1) as the main cause of Toxic Shock Syndrome (TSS). This study aimed to explore the genetic pattern of the tsst-1 genes among MSSA and MRSA from clinical isolates of patients at Dr. Soetomo General Academic Hospital, Surabaya-Indonesia. This study performed a PCR test on 106 clinical samples of S. aureus isolated to determine the presence of the tsst-1 genes; subsequently, this study also performed phylogenetic analysis. The positive tsst-1 genes were found in 3 (5.7%) MSSA isolates and 2 (3.8%) MRSA isolates from 106 samples that were divided into 53 MSSA isolated and 53 MRSA isolates. There was no significant difference between the tsst-1 genes on both the MSSA and MRSA bacteria (p = 0.648). The positive tsst-1 genes were found in 1 (4.5%) of pus specimens and 2 (16.7%) of blood specimens from MSSA isolates. However, the positive tsst-1 genes were found in neither sputum nor urine specimens. The genes were found in 2 (16.7%) of blood specimens from MRSA isolates. Based on the phylogenetic tree, Indonesian tsst-1 isolated belonged to the same clade as Japan, Iran, Iraq, India, Egypt, and the United Kingdom. The prevalence of tsst-1 genes of both MSSA and MRSA from clinical isolates in Dr. Soetomo General Academic Hospital Surabaya was 5.7% and 3.8%, respectively. The tsst-1 genes of Surabaya-Indonesia, Japan, Iran, Iraq, India, Egypt, and the United Kingdom belonged to the same clade.

Low and Moderate Intensity Exercise Decreased Body Fat and Increased Free Fatty Acid in Overweight Women Dyaksa, Rizky Sota; Liben, Paulus; Mintarto, Edy
Folia Medica Indonesiana Vol. 57, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Highlight: • Aerobic exercise was reduced body fat and increased free fatty acids. • LICT and MICT decreased body fat and increased free fatty acids. Abstract: Overweight is fat imbalances can affect the health. It is one of the problems in many countries, especially Indonesia recorded an increase case in 2007 (8.8%) to 2013 (13.5%). Overweight categorized by 25-30 kg/m2 body mass index in units (Organization 2018). Figures overweight can be pressed to provide some treatments, such as aerobics sports activities. This study aimed to determine the effect of Continuous Low Intensity Training (LICT) and Moderate Intensity Continuous Training (MICT) to decrease body fat content (FM) and increase in free fatty acids (FFA) in overweight women. 18 female subjects completed the study 4X/week exercise LICT or MICT for 5 weeks. LICT and MICT performed for 30 minutes with an additional 5 minutes warm-up and 5 minutes of cooling down with LICT intensity of 60%-70% and MICT 70%-80% of maximum HR where both types of exercise using ergo cycle while measurement FM and FFA were measured before and after practice. LICT occurred decreasing in body fat and increasing in free fatty acids that significant pre and post LICT (p < 0.05). MICT occurred decreasing in body fat and increasing in free fatty acids that significant pre and post MICT (p<0.05). In the second comparison group (LICT and MICT) were decline against body fat and an increased in free fatty acids between workouts Low-Intensity Continuous Training (LICT) greater tendency than Moderate-Intensity Continuous Training (MICT) with delta FM (p = 0.120) and delta FFA (p=0.131) in which the value is >0.05. LICT and MICT was increase while body fat was decreased. The results of a comparison test occur list downward trend in body fat while in free fatty acids was increased.

Correlation of hearing impairment and communication disorder among geriatric in geriatric clinic, dr. Soetomo hospital surabaya M, A Ratna Kartika; Purnami, Nyilo; Liben, Paulus
Folia Medica Indonesiana Vol. 51, No. 4
Publisher : Folia Medica Indonesiana

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The objective of this study was to analyze correlation between hearing impairment and communication disorder among geriatrics in Geriatric Clinic, Dr. Soetomo Hospital. A randomized cross-sectional study design has been used in this study. Analysis was done by filling in some questionnaire and interview to some patients who were randomly selected according to predetermined condition. The data were collected and reviewed for the factors, which were assumed as risk factors of hearing disorder and life's quality deterioration. Statistical analysis was performed using Fisher's Exact Test using SPSS program version 17. Results showed correlation between hearing impairment and the quality of life and social communication (p=0.033, OR=6.11). However, there was no correlation between hearing impairment with diabetes mellitus (p=0.255), with hypertension (p=0.565), and noisy environment (p=0.689). In conclusion, the study showed that there is correlation between hearing impairment and communication disorder.

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