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Mai Sarah
Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry

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KELAINAN PERKEMBANGAN KRANIOFACIAL FETUS MENCIT (Mus musculus L.) Strain DDW SETELAH PEMBERIAN EKSTRAK N-HEKSAN BUAH ANDALIMAN (Zanthoxylum acanthopodium DC.) Mai Sarah; Emita Sabri; Salomo Hutahaean
Saintia Biologi Vol 1, No 1 (2012)
Publisher : Saintia Biologi

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Abstract

The purpose of this study is  to investigate the effect of n-hexane extract of andaliman (Zanthoxylum acanthopodium DC.) fruit on craniofacial development of DDW Mice (Mus musculus L.). Experiment was carried out using Completely Randomized Design (CRD) with 5 treatments and 6 replicates. Treatments  consist  of a blank control, vehicle control (1% CMC) and 3 concentrations of andaliman extract (2%, 4% and 6%). All treatments were administered by oral gavage (0.1 ml/10 g bw) once  daily from day 0 to day 10 of gestation.  N-hexane extract of andaliman fruit induced developmental abnormalities in craniofacial structures i.e. increased the incidence of microphthalmia (P <0.05), and hydrocephalus (P <0.05). In conclusion, we suggested that andaliman fruit may have fetotoxic effects.   Keyword: andaliman (Zanthoxylum acanthopodium DC.), micropthalmia, hydrocephalus
Co-Authors Emita Sabri Salomo Hutahaean