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All Journal MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Roihatul Mutiah
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Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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Metabolite Profiling Bagian Akar, Batang, Daun, dan Biji Helianthus annuus L. Menggunakan Instrumen UPLC-MS Fitrotun Nasikhatul Maslakhah; Roihatul Mutiah; Abdul Hakim; Risma Aprinda; Arief Suryadinata
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1617.26 KB) | DOI: 10.24123/mpi.v2i2.1361

Abstract

Sunflower (Helianthus annuus L.) is one of the plants that can be used for herbal medicine as antimalaria and antioxidant. To control the quality of plant as raw material of herbal medicine, we need to analyze the metabolites or chemical compounds found in the plant. One of the techniques for this purpose is the metabolite profiling. Chemical compounds in the plants are obtained from different metabolic processes in each plant organs. The purpose of this study was to obtain the metabolite profile data, to identify the marker and major compound of roots, stems, leaves and seeds of sunflower using UPLC-MS. Each plant organ was extracted using 96% ethanol by the Ultrasound Assisted Extraction (UAE) method. Each extracts were then analyzed using the UPLC-MS instrument. The interpretation of the UPLC-MS chromatograms were then classified using multivariate Principal Component Analysis (PCA) to determine the grouping effects and characteristic compounds in each organ. Based on the research, it is known that metabolite profiles of roots, stems, leaves and seeds of sunflower were different and the concentration of major compounds in each part are 5.9490%; 5.5558%; 8.6758%; and 9.2150%, respectively.
Potential Combination of Dayak onion Eleutherine palmifolia L. and Chrysanthemum flower Chrysanthemum indicum L. as Anti-aging: Network Pharmacology Approach Fitriyani; Salsabila Eka Setia Ningrum; Roihatul Mutiah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.219-229

Abstract

Background: An anti-aging agent is a preparation or product used to inhibit skin aging. Aging occurs because of cell damage caused by free radicals. Therefore, anti-aging agents, which contain antioxidants to inhibit oxidative stress caused by free radicals, are needed. Dayak onion (eleutherine palmifolia (L) Merr.) and chrysanthemum flowers (Chrysanthemum indicum L.) have high antioxidant content, which has the potential to inhibit aging. Objective: To determine the anti-aging potential of dayak onion and chrysanthemum flower compounds Methods: Network pharmacology was performed using GeneCards (https://www.genecards.org) to obtain target genes, Cytoscape v3.10.1 software (https://cytoscape.org), DisGeNET (https://www.disgenet.org), STRING (https://www.string-db.org/), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) PATHWAY (https://www.genome.jp/kegg/pathway.html). Results: Based on Network Pharmacology, dayak onion and chrysanthemum flowers showed that 14 of the 200 target proteins were involved in biological processes and signaling pathways for premature aging syndrome. Conclusion: The combined compound from dayak onion and chrysanthemum flower has anti-aging activity due to seven bioactive components in the hydroxycinnamic acid group. This compound influences biological processes and longevity by regulating the CAD, SIRT1, and TP53 signaling pathways. Therefore, the combination of dayak onion and chrysanthemum flowers has potential as an anti-aging agent.
Co-Authors Abdul Hakim Arief Suryadinata Fitriyani Fitrotun Nasikhatul Maslakhah Risma Aprinda Salsabila Eka Setia Ningrum