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All Journal Journal of Food and Pharmaceutical Science Alchemy : Journal of Chemistry SAINSTIS Indonesian Journal of Cancer Chemoprevention Erudio: Journal of Educational Innovation Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Pharmascience Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Majalah Kesehatan FKUB FITOFARMAKA: Jurnal Ilmiah Farmasi Farmasis: Jurnal Sains Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry
Arief Suryadinata
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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UJI SITOTOKSIK KOMBINASI CISPLATIN DENGAN EKSTRAK ETANOL BENALU ALPUKAT (Dendrophthoe pentandra (L) Miq.) PADA SEL HELA Mutiah, Roihatul; Suryadinata, Arief; Nurani, Prasasti Swara
Majalah Kesehatan FKUB Vol 5, No 3 (2018): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (809.285 KB) | DOI: 10.21776/ub.majalahkesehatan.005.03.2

Abstract

Benalu alpukat (Dendrophthoe pentandra (L) Miq.) secara empiris telah digunakan sebagai obat antikanker oleh masyarakat Indonesia. Pada penelitian sebelumnya dilaporkan bahwa tanaman tersebut mengandung senyawa kuersetin. Penelitian ini bertujuan untuk mengetahui kadar kuersetin dalam ekstrak etanol 96% benalu alpukat dengan menggunakan HPLC (high performance liquid chomatography) dan untuk rnengetahui aktivitas sitotoksik kombinasi cisplatin dengan ekstrak etanol 96% benalu alpukat terhadap sel HeLa. Pengukuran kadar kuersetin dengan HPLC menggunakan kolom C-18 dan fase gerak metanol: air (59:41). Metode yang digunakan untuk uji sitotoksik adalah metode MTT assay. Hasil menunjukkan bahwa kadar kuersetin dalam ektsrak etanol 96% benalu alpukat adalah 0,116% b/v atau 0,029 mg/g bahan dengan waktu retensi 6,98 menit. Ekstrak benalu alpukat menunjukkan aktivitas yang lemah terhadap sel HeLa dengan nilai IC50 1.000±124,68 ppm, namun tidak menutup kemungkinan digunakan sebagai agen ko-kemoterapi dengan cisplatin. Hasil dari kombinasi yang menghasilkan efek sinergis dalam menghambat pertumbuhan sel kanker serviks HeLa adalah kombinasi 125 ppm EBA + 2,974 nM Cis, 125 ppm EBA + 5,95 nM Cis, 125 ppm EBA + 8,925 Cis nM, 250 ppm EBA + 2,97 Cis nM, 250 ppm EBA + 5,95 nM Cis, dan 375 ppm EBA + 11,90 Cis nM.  
ACTIVITY OF ETHYL ACETATE EXTRACT FROM Chrysophyllum cainito L. LEAVES IN DECREASING BLOOD SUGAR LEVEL IN MALE WISTAR RATS Arrijal, Imam Malikul Hadi; Ma'arif, Burhan; Suryadinata, Arief
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4996

Abstract

The high morbidity or mortality due to diabetes mellitus becomes the world health problem. That fact encourages the study about antidiabetes drugs from natural material especially plants. This study aims to analyze the effect of ethyl acetate extract from Chrysophyllum cainito L. leaves in decreasing of blood sugar level of alloxan-induced male male wistar rats. This research is considered as experimental research with pre and post test randomized controlled group design. The experimental animals in this study were 25 male male wistar rats divided into 5 treatment groups, treatment with CMC-Na (negative control), metformin with the dose of 9 mg/200gBW (positive control), and leaves extract C. cainito dose 25; 50; 75 mg/kgBW. All treatment groups had significant decrease of blood sugar levels at 7, 10 and 14 day observations with p 0.05. While in the day 3 had insignificant decrease of blood sugar level with p 0.05. Every C. cainito leaves extract doses group have the ability to decrease sugar blood level better than negative control, but still below positif control. The optimum dose in decreasing sugar blood level in this study is 75 mg/kg BW.
OPTIMASI METODE PENENTUAN KADAR LOGAM TEMBAGA DAN TIMBAL DALAM GULA PASIR SECARA SPEKTROFOTOMETRI SERAPAN ATOM DENGAN DESTRUKSI MICROWAVE DIGESTION Dewi, Diana Candra; Fauziyah, Begum; Suryadinata, Arief; Annisa, Dewi; Afifah, Nurul
ALCHEMY ALCHEMY (Vol.2 No.2
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.983 KB) | DOI: 10.18860/al.v0i0.2884

Abstract

Tembaga (Cu) dan Timbal (Pb) adalah bahan ikutan yang ditemukan dalam gula pasir. Penelitian ini  bertujuan mengetahui performa analitik kurva standar dengan penentuan suhu dan waktu terbaik destruksi menggunakan microwave digestion, serta performa analitik kurva adisi standar menggunakan suhu dan waktu terbaik destruksi.Penelitian  ini  meliputi penentuan performa  analitik  untuk kurva  standar yaitu linearitas, batas deteksi dan batas kuantitasi, sensitivitas, akurasi serta presisi untuk larutan standar Cu dan Pb, kemudian dilakukan pendestruksian sampel gula pasir dengan destruksi basah menggunakan microwave digestion dengan variasi suhu 160, 180 dan 200 oC dan variasi waktu 10, 15, 20 dan 30 menit dan waktu penyimpanan 1 sampai 5 hari. Penentuan  performa  analitik  juga ditentukan pada  kurva adisi standar untuk larutan Cu dan Pb yang telah ditambahkan sampel hasil destruksi.Hasil penelitian menunjukkan bahwa : Suhu dan waktu terbaik destruksi gula pasir menggunakan microwave digestion untuk analisis Cu yaitu suhu 200 oC dan waktu 15 menit serta waktu penyimpanan sampai 3 hari. Suhu dan waktu terbaik microwave digestion untuk menganalisa logam timbal (Pb) adalah 180 0C dan 10 menit serta waktu penyimpanan hanya sampai 1 hari. Performa  analitik  untuk kurva  standar  tembaga (Cu) meliputi r2 = 0,9993; LOD (Limit of Detection) 0,0011 ppm dan LOQ (Limit of Quantitation) 0,0036 ppm;  sensitivitas 0,2; rata-rata akurasi sebesar 99.96%; serta presisi 9,46%, sedangkan performa  analitik  untuk  kurva  adisi  standar  tembaga (Cu)  meliputi  r2 = 0,9999; LOD 0,0012 ppm dan LOQ 0,004 ppm; sensitivitas 0,1729, rata-rata akurasi sebesar 100,07% serta presisi 5,38%. Performasi analitik untuk kurva standar timbal (Pb) meliputi r2 = 0,9999; LOD 0,0019 ppm,  LOQ 0,0066 ppm; sensitivitas 0,1069 ppm ; rata-rata akurasi sebesar 99,56 % serta presisi 2,32 %. Performasi analitik kurva adisi standar timbal (Pb) meliputi r2 = 0,9999; LOD 0,0018 ppm, LOQ 0,0060 ppm; sensitivitas 0,1090 ppm; rata-rata akurasi sebesar 100,01 % serta presisi 1,94 %.
Oil Extraction from Rice Bran with Various Solvents and Concentration of Crude Extract to Antioxidant Activity Suryadinata, Arief
ALCHEMY ALCHEMY (Vol.4, No.1
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.21 KB) | DOI: 10.18860/al.v4i1.3152

Abstract

Rice bran contains components such as oryzanol antioxidants, tocopherols, tocotrienols, phytosterols, polyphenols, and squalene. Oryzanol is a very powerful antioxidant and oryzanol is only found in rice bran oil. This research aims to know the antioxidant activity of the extract chloroform:methanol in the bran and find the endurance of antioxidant against a wide variety of pH and temperature. The method used is descriptive research through experimental tests in the laboratory. Samples taken from the side of rice mills in the form of bran and then macerated with chloroform: methanol. After that tested the antioxidant activity of the compounds made by the method of DPPH with various concentration 10, 20, 30, 40 and 50 ppm. Furthermore, the endurance test of antioxidant compounds at various pH and temperature using the best concentration of antioxidant compounds. Based on the results, rice bran oil extract concentration of 50 ppm has antioxidant activity of 4.69%. Average yield the highest antioxidant activity shown in heating conditions with a temperature of 30oC for 30 minutes is equal to 32.25%. As well as the highest antioxidant activity was also shown at pH 5 in the amount of 25.1%. Keywords: DPPH, Oryzanol, Rice bran
Kajian Efek Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr) sebagai Antikanker Muti'ah, Roihatul; Listiyana, Anik; Nafisa, Belia Bima; Suryadinata, Arief
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9778

Abstract

Dayak onion (Eleutherine palmifolia (L.) Merr) is a typical plant in Central Kalimantan. This plant has been passed down for generations by Indonesian people for various treatments. The potential of dayak onions that have various pharmacological activities needs to be increased in their use as modern medicinal ingredients. The purpose of this literature study is to review the various uses, the secondary metabolites content, and the action mechanism as an anticancer both in vitro, in vivo, and in silico. The results of this literature study show that traditionally the Indonesian people use the bulbs for the treatment of breast cancer, colon cancer, hypertension, diabetes mellitus, stroke, fever, dysuria, intestinal inflammation, dysentery, boils, cysts, prostate, lowering cholesterol and triglycerides, breastfeeding and sexual disorders. In the empiric treatment of cancer, this plant is used by drying the bulbs and chewing it. Dayak onion bulbs (Eleutherine palmifolia (L.) Merr) are known to contain flavonoid compounds wich isoliquiritigenin, polyphenols group wich oxyresveratrol and naphtoquinon group, and its derivatives such as elecanacine, eleutherine, eleutherol, eleutherinol, eleutherinon, eleuthoside B, eletherinoside A which has anti-cancer activity. Pre-clinical studies with in vitro and in vivo mechanism showed that dayak onion bulbs (Eleutherine palmifolia (L.) Merr) extracts have pharmacological activities, which are anti-cancer that can inhibit cell signaling through apoptosis and cell cycle arrest. Also, the mechanism of in silico showed anti-cancer activity from the inhibition of VHR receptors, BCL-2 receptors, VEGFR-2 receptors and alpha estrogen receptors (ERα).
Analisis Kandungan Logam Berat Cd, Hg, dan Pb Daun Semanggi (Marsilea crenata Presl.) di Desa Semen, Kecamatan Pagu, Kabupaten Kediri Ma'arif, Burhan; Muti'ah, Roihatul; Suryadinata, Arief; Nashichuddin, Ach; Karawid, Galih Elsy
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9356

Abstract

Semanggi (Marsilea crenata Presl.) berpotensi untuk diolah menjadi produk obat herbal karena khasiat yang dimilikinya. Namun, tanaman semanggi (Marsilea crenata Presl.) memiliki kemampuan fitoremediasi sehingga berdampak pada penimbunan logam berat yang berbahaya untuk kesehatan tubuh. Penelitian ini dilakukan untuk mengetahui kandungan logam berat Cd, Hg dan Pb pada daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) untuk dibandingkan dengan Perka BPOM No. 12 tahun 2014 terkait batas logam berat untuk simplisia. Metode yang digunakan yaitu menggunakan Atomic Absorption Spectroscopy (AAS) pada sampel simplisia daun tanaman semanggi dan juga sampel tanah sebagai pembanding. Dari hasil pengujian sampel simplisia daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) terdapat (Cd) dengan kadar 4,16 ppm. Hasil ini menunjukkan tidak memenuhi standar Perka BPOM No. 12 tahun 2014 karena melewati batas minimum Cd sebesar ≤ 0,3 ppm.
HIDROLISIS GUGUS METOKSIL PEKTIN AMPAS TEBU UNTUK MENGHASILKAN BIOMETANOL Akyunul Jannah; Arief Suryadinata
SAINSTIS SAINSTIS (Vol 1, No 2
Publisher : Lembaga Penelitian dan Pengembangan Universitas Islam Negeri Maulana Malik Ibrahim Malang.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (711.294 KB) | DOI: 10.18860/sains.v0i0.2303

Abstract

Methanol is a potential in two areas, namely as fuel cells and biodiesel. Among the many biomass, pectin is one of the best for the production of methanol. The purpose of this study was to determine the influence of pectin methyl esterase enzyme  concentration  (PME)  group  metoksil  rough  on  pectin  hydrolysis  of bagasse to produce the highest levels of biometanol. Methods This study includes the preparation of the bagasse, further hydrolysis using crude extract of the enzyme pectin methyl esterase (PMEs) resulting from bacterial culture Bacillus subtilis at Borth Nutrient media (NB) with 1% pectin. Hydrolysis of Metoksil groups of poligalakturonat acid in the pectin bagasse to obtain the concentration of methanol to vary the enzyme crude extract PMEs. Concentration of crude enzyme extract PMEs used was 10%, 15%, 20% and 25% in 24-hour incubation with 2 repetitions performed. The resulting methanol levels were analyzed using GC (Gas Chromatography). The results of this study concluded that allowing the concentration used for hydrolysis of bagasse to produce methanol using crude enzyme from  Bacillus subtilis (PMEs) is 10% with a methanol content of 0.02%.
KADAR BIKARBONAT SALIVA PENDERITA KARIES DAN BEBAS KARIES Arief Suryadinata
SAINSTIS SAINSTIS (Vol 1, No 1
Publisher : Lembaga Penelitian dan Pengembangan Universitas Islam Negeri Maulana Malik Ibrahim Malang.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.935 KB) | DOI: 10.18860/sains.v0i0.1868

Abstract

Saliva plays a role as a buffer so that the ups and downs of the degree of acidity (pH) can be retained. salivary buffer capacity is determined by the bicarbonate concentration of 85%, 14% is determined by the concentration of phosphate and 1% by salivary proteins. Bicarbonate is the main component of saliva to neutralize the acid thus inhibiting the caries process. Based on the role of  bicarbonate in maintaining the pH of saliva to remain normal, there may be differences in levels of salivary bicarbonate in subjects  with caries and caries-free. This is because subjects with dental caries have the potential for acid formation and a decrease in pH higher than subjects with caries-free. This study aims to determine differences in levels of salivary bicarbonate in subjects  with caries and caries-free, studies are observational analytic study. Based on the result showed average levels of bicarbonate in the saliva of caries-free sample is 188.9440 ± 7.11846 ppm while in samples with high caries intensity is 150.9905 ± 9.76628 ppm, then the results of Kolmogorov-Smirnov normality test p-value of 0.200 obtained (p 0.05) in the sample with high intensity of caries and caries-free sample group. The results of the statistical test T-test two sample unpaired in getting the value of p = 0.000 (p 0.05), This means there are significant differences between the levels of salivary bicarbonate in subject with caries and caries-free.
SCOT (Structured Clinical Operative Test) : Penilaian Kompetensi Mahasiswa Kedokteran Gigi Dalam Melakukan Prosedur Tindakan Invasif Citra Insany Irgananda , Arief Suryadinata
Erudio Journal of Educational Innovation Vol 2, No 1 (2013): ERUDIO (JOURNAL OF EDUCATIONAL INNOVATION)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Penilaian merupakan komponen penting atas pengalaman belajar yang diberikan kepada mahasiswa. Hasil penilaian dapat digunakan mengidentifikasi kelebihan dan kekurangan mahasiswa, untuk mengevaluasi sebuah kurikulum, untuk memantau perkembangan mahasiswa, dan mengetahui pencapaian akhir dari kompetensi yang meliputi kapasitas mereka pada level praktis. SCOT adalah sebuah metode penilaian yang digunakan dalam penilaian terhadap prosedur klinis yang invasif. Sebuah metode yang dapat digunakan untuk melengkapi OSCE dalam penilaian secara keseluruhan terhadap penilaian kompetensi klinis dan bersifat sebagai penilaian formatif. SCOT menilai kemampuan praktik tindakan operasi dalam kurikulum program profesi dokter gigi. Kata Kunci: SCOT, Penilaian Formatif, Kompetensi Klinis
The Profile of Anticancer Activities of Sambiloto Extract (Andrographis paniculata Nees) from Several Locations in East Java Roihatul Mutiah; Fina Luthfiana; Arief Suryadinata; Wirda Anggraini; Anik Listiyana
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.647

Abstract

Sambiloto (Andrographis paniculata Nees) contains andrographolid compound which has potentialas an anticancer. The difference of growth location has affected the distinction of metabolite content. Thisstudy aims to determine the profile of anticancer activities of A. paniculata extract from several locations inEast Java. The extracts from several locations were tested for activity on T47D cancer cell using MTT assaymethod. Thus, the result of this study describes that A. paniculata extract from several different locations doesnot provide significantly different anticancer activities with the amount of (p>0.05). The extracts which havemoderate anticancer activity were A. paniculata extracts from Selopuro Subdistrict Blitar Regency, SingosariSubdistrict Malang Regency, Lowokwaru Subdistrict Malang City, Klojen Subdistrict Malang City,Purwodadi Subdistrict Pasuruan Regency, Purwosari Subdistrict Pasuruan Regency, and PandaanSubdistrict Pasuruan Regency
Co-Authors AA Sudharmawan, AA Abdul Hakim Abdul Hakim Abdul Wafi Ach. Nashichuddin Ahmad, Ananda Rizkia Azizah Akyunul Jannah Almay Abidzar Elpasha Ami Fini Faqiha Amrulloh, Muhammad Firman Ana Rahmawati Anik Listiyana Arrijal, Imam Malikul Hadi Artabah Begum Fauziyah Begum Fauziyah Briliana, Malich Septi Diajeng Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Chamlah Ayatillah Daffa Dhiya Ulhaq Denis Dewi Annisa, Dewi Diana Candra Dewi Fahrul Rizki Faisal Akhmal Muslikh Fina Luthfiana Fitria Rahma Fauzia Fitrotun Nasikhatul Maslakhah Fransiska Rosari Dewi Fuadi, Muhammad Nauval Nadhirul Hening Laswati Putra Janaloka, Nandana Adyuta Karawid, Galih Elsy Ma'arif , Burhan Ma'arif, Burhan Ma'arif, Burhan Mangestuti Agil Meilina Ratna Dianti Muhammad Afif Muhammad Amiruddin Muti'ah, Roihatul Mutiah, Roihatul Nafisa, Belia Bima Ni Nyoman Sri Budayanti Novia Maulina Nurani, Prasasti Swara Nurwijayanti Pradita Fiqlyanur Isna Primadana Qonita, Kesimira Rani Azzahara Risma Aprinda Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Sholekhah, Syafirda Arma'atu Suryanto Suryanto Tanaya Jati Dharma Dewi Ulfah, Jauza Wirda Anggraini Wirda Anggraini Yen Yen Ari Indrawijaya