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All Journal MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Berkala Penelitian Hayati
Harry Santosa
Departeman Kimia Farmasi, Fakultas Farmasi Universitas Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Sintesis Senyawa Propan-2-il-tetradekanoat melalui Metode Refluks dan Kombinasi dengan Iradiasi Gelombang Mikro Harry Santosa
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 3 (2019): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (502 KB) | DOI: 10.24123/mpi.v2i3.1563

Abstract

Tujuan penelitian ini adalah melakukan sintesis senyawa propan-2-il-tetradekanoat dari asam miristat dan 2-propanol dengan katalis asam sulfat pekat. Ada dua metode yang digunakan yaitu metode konvensional dan kombinasi melalui iradiasi gelombang mikro. Hasil penelitian ini menunjukkan bahwa metode iradiasi gelombang mikro memberikan persentase produk yang lebih baik (85%) dibandingkan dengan metode konvensional (64%). Uji kemurnian hasil sintesis menggunakan KLT dengan berbagai fase gerak menunjukkan keberhasilan baik metode konvensional maupun iradiasi gelombang mikro dalam menghasilkan senyawa produk. Senyawa propan-2-il tetradekanoat yang diperoleh kemudian dikarakterisasi sifat fisikanya dan diperoleh data antara lain titik didih = 237-240°C (210 mmHg); indeks bias (nD) = 1,4353 (20°C) ; densitas = 0,8518 (25°C). Data karakterisasi struktur menggunakan IR dan NMR juga berhasil mengonfirmasi terbentuknya senyawa propan-2-il tetradekanoat yang ditunjukkan dengan adanya gugus fungsi ester serta total proton beserta lingkungan kimianya.
Synthesis and Molecular Docking Studies of N’-benzoylsalicylhydrazide derivatives as antituberculosis through InHA enzym inhibition Harry Santosa; Galih Satrio Putra; Tegar Achsendo Yuniarta; Tutuk Budiati
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1120.908 KB) | DOI: 10.14499/indonesianjpharm29iss4pp198

Abstract

The specific aims of this study is to synthesize and to study the possible mechanism of N’-benzoylsalicylhydrazide derivatives as an antituberculosis agent through InhA (Enoyl acyl carrier protein reductase) inhibition using in silico method. Five analogues of N’-benzoylsalicylhydrazide were synthesized using microwave irradiation from methyl salicylate as starting material, which yielded 80-90% product on average. This indicates a considerable improvement in terms of effectivity and efficiency, compared to the more conventional method using reflux condition. Character-ization of the compounds were subsequently carried out by UV, FTIR, 1H-NMR, 13C-NMR spectroscopy, which confirmed that the compounds had been successfully synthesized. Ultimately, molecular docking was performed using Molegro Virtual Docker (MVD) on the active site of InhA enzyme to predict the activity of the compounds. The results showed that all compounds performed comparatively well against N-(4-Methylbenzoyl)-4-benzylpiperidine as the native ligand and also yielded lower docking score than isoniazide (INH). From this study it can be concluded that N’-benzoylsalicylhydrazide derivatives could be synthesized using microwave irradiation with good product yield and all of the synthesized analogues are suggested to possess antituberculosis activity via InhA enzyme inhibition. In vitro activity will have to be determined in the future to validate whether N’-benzoylsalicylhydrazide derivatives perform well as a potential antituberculosis agent.
AKTIVITAS ANTIBAKTERI NBENZOILAMOKSISILIN DAN N34DIKLOROBENZOILAMOKSISILIN TERHADAP Staphylococcus ATCC 25923 DAN Escherichia coli ATCC 35218 Harry Santosa; Bambang Soekardjo; Ami Soewandi J S
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 5 No 2 (2000): June 2000
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/470

Abstract

N-Benzolamoxicillin and N-3,4-dichlorobenzolamoxicillin were synthesized from amoxicillin by acylation with benzoylchloride and 3,4-dichlorobenzoylchloride respectively. Structure characterization of the amoxicillin derivative compounds were done by UV, IR and 1H-NMR spectroscopy. Both derivative compound has antibacterial antivity against Staphylococcus aureus and Escherichia coli. The activity of N-3,4-dichlorobenzolamoxicillin is more active than N-Benzolamoxicillin.
Co-Authors Ami Soewandi J S Bambang Soekardjo Galih Satrio Putra Tegar Achsendo Yuniarta Tutuk Budiati