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I. Lestari
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jl. Margonda Raya, Depok 16424, Indonesia
Materials Science & Nanotechnology

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In Vitro Release of Metformin HCl from Polyvinyl Alcohol (PVA) - Gelatin Hydrogels Prepared by Gamma Irradiation H Hariyanti; E Erizal; E. Mustikarani; I. Lestari; F. Lukitowati
Atom Indonesia Vol 48, No 1 (2022): April 2022
Publisher : PPIKSN-BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/aij.2022.1123

Abstract

The aim of this present work is to use polyvinyl alcohol (PVA) – gelatin-based  hydrogel prepared by γ-rays irradiation with different gelatin concentrations ranging from 0.5 - 2 %w/v for immobilization of Metformin HCl (MH) at dose range of 0 - 30 mg. The mixture were freezed-thawed for 3 cycles, irradiated using  γ-rays with sterilization dose at 25 kGy (dose rates 5 kGy/h). Gel fraction and water absorption were determined gravimetrically. The surface morphology of hydrogels were observed using Scanning Electron Microscope (SEM). In vitro release of MH were taken using UV-Vis spectrophotometer. After evaluated, it was found that with increasing gelatin concentrations, gel fraction increases and water absorption decreases. With increasing gelatin concentration and drug dosage, the cumulative drug released decreases. From SEM observation, the hydrogel had a heterogeneous porous. The hydrogel based on PVA-gelatin can be considered as a matrix for controlled drug release and safe for humans since both PVA and gelatin are non-toxic.
Synthesis of Polyvinyl Alcohol (PVA)-Gelatin Hydrogel from White Snapper (Lates calcarifer, Bloch) with Gamma Irradiation and Its Characterizations H Hariyanti; E Erizal; R. Z. Apriyani; D. P. Perkasa; I. Lestari; H. Rahmi
Atom Indonesia VOL 49, NO 2 (2023): AUGUST 2023
Publisher : National Research and Innovation Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/aij.2023.1248

Abstract

The application of nuclear technology in the health sector is increasing. One example is the use of irradiation in production of wound dressings. Research activities have been conducted to study whether polyvinyl alcohol (PVA)-gelatin-based hydrogel from white snapper scales can be processed using gamma irradiation into wound dressings. A series of PVA (10 %) solutions containing gelatin in various concentrations (0-4 %) were treated with three freeze-thaw cycles and then irradiated at doses of 10 and 20 kGy. They were subsequently characterized using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscope (SEM). Gel fraction, water absorption, and percentage of hydrogel water evaporation rate were tested gravimetrically, while the elongation at break and the tensile strength of the hydrogels were tested with a universal testing meter. The evaluation showed that the hydrogel gel fraction decreased with increasing gelatin concentration from 0 % to 4 % for both irradiation doses (10 and 20 kGy). The rising gelatin concentration demonstrated that increasing gamma radiation dose improved the hydrogel's water absorption, evaporation rate, tensile strength, and elongation at break. PVA-gelatin hydrogel with irregular pore structure was observed from SEM test results. The FTIR measurement results confirmed the formation of crosslinks in the hydrogel matrix. The PVA-gelatin hydrogel produced through gamma irradiation could be used for wound dressings.
Co-Authors D. P. Perkasa E Erizal E Erizal E. Mustikarani F. Lukitowati H. Rahmi Hariyanti Hariyanti R. Z. Apriyani