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All Journal INDONESIAN JOURNAL OF PHARMACY
Arief Nurrochmad
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Medicine & Pharmacology

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Effect of Curcuma zedoaria Rosc. ethanolic extract on the lung tumor growth on post initiation phase in female mice induced by Benzo(a)pyrene Retno Murwanti; Edy Meiyanto; Arief Nurrochmad; Susi Ari Kristina
Indonesian Journal of Pharmacy Vol 15 No 1, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.981 KB) | DOI: 10.14499/indonesianjpharm0iss0pp7-12

Abstract

Curcuma zedoaria Rosc. rhizomes has been used as a traditional cancer medicine since a long time ago, but the so far researches performed on the pharmacological mechanism were lacking. This present research has been done to determine the effect of ethanolic extract of Curcuma zedoaria Rosc. rhizomes on lung cancer of female mice previously induced by Benzo[a]pyrene (B[a]P).Newborn mice were induced by B[a]P and then were separated between male and female mice. On 30th day after birth, female mice were given the ethanolic extract of Curcuma zedoaria Rosc. rhizomes and divided into five groups. Three groups were given 200, 500 and 750 mg/kgBB extract, a group was given solvent (DMSO) as negative control, and another group was given nothing as positive control.The results of this present research shown that the ethanolic extract of Curcuma zedoaria Rosc. rhizomes has proved to posses inhibition effect on lung cancer growth in female mice, at dose of 250 mg/kgBB (49,63%), 500 mg/kgBB (73,33%) and 750 mg/kgBB (77,78%).Keywords : Newborn Mice, Benzo[a]piren, Curcuma zedoaria Rosc.
Co-Authors Edy Meiyanto Retno Murwanti Susi Ari Kristina