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All Journal INDONESIAN JOURNAL OF PHARMACY
Partomuan Simanjuntak
Biotechnology Center Science Institute of Indonesia Jalan Raya Bogor Km 46 Cibinong 16911
Medicine & Pharmacology

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BIOTRANSFORMATION OF CINCHONA ALKALOID COMPOUNDS BY MOLD Xylaria sp.TO CINCHONA N-OXIDE ALKALOIDS [Studies on Endophytic Microbes of Cinchona spp. plants (5)] Partomuan Simanjuntak; Bustanussalam .; Titik K. Prana; K. Ohashi; Hirotaka Shibuya
Indonesian Journal of Pharmacy Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.247 KB) | DOI: 10.14499/indonesianjpharm0iss0pp95-100

Abstract

A biotransformation study on alkaloid chinchona compounds (quinine, quinidine, cinchonidine, cinhonine) by endophytic microbe from Cinchona succirubra have been done. The biotransformation for 2 days after preculture yielded cinchona N-oxide compounds (quinine N-oxide, quinidine N-oxide, cinchonidine N-oxide, cinchonine N-oxide) alkaloids and the bioassay of the compounds also showed effectiveness as antimalaria. Purification the biotransfomed compound was conducted by a high performance liquid chromatograph (HPLC) and determination of chemical structure was done based on carbon nuclear magnetic resonance (NMR).Key words : Biotransformation, endophyte microbe, Xylaria sp., Cinchona succirubra Pav., cinchona alkaloid, quinine, quinine N-oxide
Co-Authors Bustanussalam . Hirotaka Shibuya K. Ohashi Titik K. Prana