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Asep Gana Suganda
School of Pharmacy Institut Teknologi Bandung
Medicine & Pharmacology

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The antifungal activity test of ointment and cream preparations of ”ketapang” (Terminalia cattapa L.) leaf on rabbit’s skin Elinah Yuli Sukandar; Asep Gana Suganda; Gemi Utami Pertiwi
Indonesian Journal of Pharmacy Vol 17 No 3, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.702 KB) | DOI: 10.14499/indonesianjpharm0iss0pp123-129

Abstract

Ketapang (Terminalia catappa L.) leaves has been used traditionally as skin infectious disease medicine, therefore ethanolic extract of ketapang leaves was formulated in ointment and cream preparations to be tested against fungi causing dermatomycosis i.e. Trichophyton mentagrophytes. The antifungal activity of both preparations was been tested in Trichophyton mentagrophytes infected rabbit’s skin. Result showed that ointment and cream containing 10 % extract were active against the fungi compared to the control. Healing occured on day 11.0 ± 3.0 in ointment treated rabbits, and ointment on day 12.7 ± 3.5 in cream treated rabbits, whereas in control healing occured on day 16.7 ± 6.6. Skin iritation index and eye irritation scores for ointment were 0.33 (maximum score 3) and 9.95 (maximum score 110) respectively, whereas those for the cream were 0.71 and 15.69, respectively.Key words: antifungal, Trichophyton mentagrophytes, ointment, Cream.
Co-Authors Elinah Yuli Sukandar Gemi Utami Pertiwi