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All Journal INDONESIAN JOURNAL OF PHARMACY
Katsuhiro Ueda
Dept of Chemistry, Biology and Marine Science, Univ. Ryukyus, Senbaru, Nishihara, Okinawa 903-0213, Japan
Medicine & Pharmacology

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ANTIMICROBIAL METABOLITES FROM A MARINE-DERIVED FUNGUS Wilmar Maarisit; Katsuhiro Ueda
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (397.513 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-169

Abstract

A marine fungus was separated from the surface of a marine red algae. Ethyl acetate extract of the cultivated marine fungus inhibited the growth of the pathogenic bacteria E.coli and S.aureus, and the phytopathogenic fungus C. cucurbitarum. Separation of the EtOAc extract gave four compounds, which were identified as new anthraquinonederivatives 3 and 4, and the known chrysophanol (1) and rubelin A (2) by the extensive analysis of NMR data. Compounds 1-4 inhibited the growth of the gram negative bacteria E. coli and gram positive bacteria S. aureus. Compound 3 also inhibited the fungus C. cucurbitarum.Key words: marine-derived fungus, structure elucidation, anthraquinone, antimicrobial activity
Co-Authors Wilmar Maarisit