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Sudarsono .
Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta
Medicine & Pharmacology

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Isolation of cytotoxic substance from Kaliapsis sponge Erna Prawita Setyowati; Umar Anggara Jenie; Sudarsono .; Broto Kardono; Rachmaniar Rahmat; Edy Meiyanto
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.384 KB) | DOI: 10.14499/indonesianjpharm0iss0pp183-189

Abstract

An isolation of cytotoxic substance of Kaliapsis sponge has been conducted. The substance was isolated using maceration, partition, vacuum liquid chromatography and preparative thin layer chromatograpy methods.The result of research showed that peak 1 has the most cytotoxic activity. Cytotoxicity test with MTT [3 (4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromide] reagen on myeloma cell showed that the peak 1 had a high activity against myeloma cell. It has IC50 equal to 0,18 μg/mL.Key word: Kaliapsis sponge, cytotoxic, myeloma cell
Co-Authors Broto Kardono Edy Meiyanto Erna Prawita Setyowati Rachmaniar Rahmat Umar Anggara Jenie