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Slamet Ibrahim
School of Pharmacy Institut Teknologi Bandung
Medicine & Pharmacology

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Identification of physical interaction between levodopa–benzerazide hydrochloride Ilma Nugrahani; Sukmadjaja Asyarie; Sundani Noerono Soewandhi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1353.355 KB) | DOI: 10.14499/indonesianjpharm0iss0pp96-104

Abstract

The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.
Co-Authors Ilma Nugrahani Sukmadjaja Asyarie Sundani Noerono Soewandhi