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All Journal Jurnal Tumbuhan Obat Indonesia Buletin Penelitian Tanaman Rempah dan Obat Generics: Journal of Research in Pharmacy
Rissa Vifta
Universitas Ngudi Waluyo
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Medicine & Pharmacology Public Health

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Aktivitas In Vitro Penurun Gula Darah dari Ekstrak Buah Parijoto (Medinilla speciosa B.) Rissa Vifta; NFN Wilantika; Yustisia Dian Advistasari
Buletin Penelitian Tanaman Rempah dan Obat Vol 31, No 1 (2020): Buletin Penelitian Tanaman Rempah dan Obat
Publisher : Pusat Penelitian dan Pengembangan Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/bullittro.v31n1.2020.31-39

Abstract

Diabetes mellitus is one of the highest causes of death in the world, with symptoms of increased blood glucose levels (hyperglycemia). One of the efforts made as a treatment and prevention of DM is through complementary therapy using natural ingredients. Parijoto fruit (Medinilla speciosa) contains flavonoid compounds potential to reduce glucose levels. The study aimed to analyze the effectiveness of ethanol extracts and its fractions of parijoto fruit (EEBP) to decrease glucose levels in vitro. The study was conducted at the Ngudi Waluyo University Laboratory in April to August 2018. Identification and screening of flavonoid compounds from ethanol extracts and its fractions of parijoto fruit were performed qualitatively and by thin-layer chromatography (TLC). In vitro testing for  antidiabetic activity of EEBP was performed with non-enzymatic reaction by Nelson Somogyi method (ethanol extract and its fractions). Experiment  was arranged in a randomized block design, with 12 treatments and three replications. The concentrations of parijoto fruit tested were 10 ppm, 20 ppm, 30 ppm, 40 ppm, 50 ppm, and 60 ppm. The results of qualitative identification and TLC showed that the ethanol extract and its fraction of EEBP contained flavonoid compounds. At a concentration of 30 ppm, EEBP was able to reduce glucose levels by 42.43 %, while the ethanol fraction decreased glucose levels by 83.38 %. The results showed parijoto fruit ethanol extract and its fractions were sources of antidiabetic. Hence its pharmacologically effect was necessary to be further studied.
STUDI IN VITRO POTENSI ANTIOKSIDAN DAN AKTIFITAS ANTIDIABETES FRAKSI ETIL ASETAT BUAH PARIJOTO (Medinilla speciosa B.) Rissa Vifta; Wilantika Wilantika; Yustisia Dian Advistasari
Jurnal Tumbuhan Obat Indonesia Vol 12 No 2 (2019): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1126.451 KB) | DOI: 10.22435/jtoi.v12i2.1160

Abstract

ABSTRACT Parijoto fruit (Medinilla speciosa B) contains the flavonoid which is one of the phenolic groups compounnd. Flavonoids has biological activities as anti free radical and antionxidants. The aim of this research was to evaluate the potency of ethyl acetat fraction of M.speciosa B. Extract as an antioxidants and antidiabetic. Evaluation of antioxidants activity was carried out by in vitro assay using the ABTS method (2.2 azinobis (3-ethylbenzotiazolin) -6-sulfonic acid), while the antidiabetic assay was carried out using the Nelson-Somogyi method. Research begins with the process of determination, extraction, fravtionation and contiunued by examination of each variable. The parameters of antioxidants activity was determined by IC50 values, while antidiabetic activity was measured by percentage of decreasing of glucoce levels. The results of antioxidants activity showed that ethyl acetate fraction of M. Speciosa B. had antioxidants activity with an IC50 value of 4,246 ppm with a very strong category. In line with these results, ethyl acetate fraction of M. speciosa B. had reduced glucoce levels with an optimal decrease of 50.21% a concentration of 40 ppm. ABSTRAK Buah Parijoto (Medinilla speciosa B.) mengandung senyawa aktif flavonoid yang merupakan salah satu golongan fenolik. Flavonoid memiliki aktifitas biologis sebagai antiradikal bebas dan antioksidan. Penelitian dilakukan dengan tujuan mengetahui kemampuan fraksi etil asetat M. speciosa B sebagai antioksidan dan antidiabetes. Pengujian aktifitas antioksidan dilakukan secara in vitro dengan metode ABTS (2,2 azinobis (3-etilbenzotiazolin)-6-asam sulfonat), sedangkan uji antidiabetes dilakukan menggunakan metode Nelson-Somogyi. Penelitian diawali dengan proses determinasi, ekstraksi, fraksinasi, dan dilanjutkan dengan pengujian pada masing-masing variabel. Parameter aktifitas antioksidan diwujudkan dengan nilai IC50, sedangkan aktiftas antidiabetes diukur dengan persen penurunan kadar glukosa. Hasil pengujian aktifitas antioksidan menunjukkan bahwa fraksi etil asetat memiliki aktifitas antioksidan dengan nilai IC50 sebesar 4.14±0.08 ppm dengan kategori sangat kuat. Sejalan dengan hasil tersebut, fraksi etil asetat Buah Parijoto (M. speciosa B.) memilili kemampuan dalam menurunkan kadar glukosa dengan penurunan secara optimal sebesar 50.21±0.47% pada konsentrasi 40 ppm.
Uji Aktivitas Antibakteri Ekstrak Etanol 70% dan Ekstrak Etanol 96% Buah Strawberry (Fragaria X Ananassa) terhadap Bakteri Propionibacterium acnes Wahyu Adiningsih; Rissa Vifta; Richa Yuswantina
Generics: Journal of Research in Pharmacy Vol 1, No 1 (2021): Generics : Journal of Research in Pharmacy, Volume 1, Edisi 1, 2021
Publisher : Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.33 KB) | DOI: 10.14710/genres.v1i1.9835

Abstract

Buah strawberry (Fragaria x ananassa) mengandung senyawa aktif, flavonoid, tanin, dan saponin. Buah strawberry (Fragaria x ananassa) merupakan salah satu sumber penting fitokimia yang memiliki banyak manfaat bagi kesehatan manusia, salah satunya adalah sebagai anti mikroba. Penelitian ini bertujuan untuk uji aktivitas antibakteri dari ekstrak etanol 70% dan 96%  buah strawberry (Fragaria x ananassa) akan diuji terhadap Propionibacterium acnes. Penelitian dimulai dengan maserasi menggunakan pelarut etanol 70% dan 96%. Sedangkan aktivitas antibakteri menggunakan metode difusi cakram menggunakan variasi konsentrasi 1%, 2%, dan 3% dengan menggunakan perbandingan antibiotik clindamycin. Ekstrak buah strawberry (Fragaria x ananassa) diperoleh hasil etanol 70% (10,25%) dan etanol 96% (11,08%). Etanol 70% konsentrasi 1% memiliki diameter 10,89 mm, konsentrasi 2% 14,63 mm dan 3% 16,60 mm. Etanol 96% konsentrasi 1% memiliki diameter 12,03 mm, konsentrasi 2% 16,67 mm dan 3% 19,17 mm. Hasil statistik etanol 70% dan 96%  aktivitas antibakteri keduanya memiliki aktivitas antibakteri yang tidak jauh berbeda sebagaimana dibuktikan dari uji statistik T-Test dengan p-Value > 0,05. Ekstrak etanol 70% dan 96% buah strawberry (Fragaria x ananassa) dapat menghambat pertumbuhan Propionibacterium acnes dengan konsentrasi optimal 3%.
Co-Authors Advistasari, Yustisia Dian NFN Wilantika Richa Yuswantina Wahyu Adiningsih Wilantika Wilantika Yustisia Dian Advistasari