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All Journal Jurnal Kedokteran Diponegoro Ophthalmologica Indonesiana
Lisana Himmatul Ulya
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Health Professions Medicine & Pharmacology Public Health

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PENGARUH PEMBERIAN EKSTRAK DAUN PIPER CROCATUM DOSIS BERTINGKAT TERHADAP PROLIFERASI LIMFOSIT LIMPA: STUDI PADA MENCIT BALB/C YANG DIINFEKSI SALMONELLA TYPHIMURIUM Lisana Himmatul Ulya; Akhmad Ismail; Neni Susilaningsih
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.074 KB) | DOI: 10.14710/dmj.v5i4.14807

Abstract

Latar Belakang : Piper crocatum (sirih merah) merupakan tanaman yang dikenal luas di Indonesia dan dimanfaatkan sebagai tanaman obat. Kandungan senyawa sirih merah antara lain alkaloid, flavonoid, saponin, triterpenoid, dan tannin. Ekstrak daun sirih merah memiliki efek imunomodulator.Tujuan : Membuktikan adanya pengaruh pemberian ekstrak daun Piper crocatum dosis bertingkat terhadap proliferasi limfosit limpa mencit Balb/c yang diinfeksi Salmonella typhimurium.Metode : Penelitian eksperimental laboratorik dengan post test only control group design. Sampel sebanyak 25 ekor mencit balb/c diadaptasi selama 7 hari. Mencit balb/c dibagi secara simple random sampling menjadi 5 kelompok. Kelompok K1 diberi ekstrak Piper crocatum peroral 10 mg/mencit/hari, K2 diinfeksikan Salmonella typhimurium secara intraperitoneal, P1 diberi ekstrak Piper crocatum peroral 10 mg/mencit/hari, P2 diberi ekstrak Piper crocatum peroral 30 mg/mencit/hari, P3 diberi ekstrak Piper crocatum peroral 100 mg/mencit/hari, dan semua kelompok perlakuan diinfeksikan Salmonella typhimurium intraperitoneal. Pada hari ke 15 semua mencit terminasi dan dilakukan pemeriksaan proliferasi limfosit metode MTT Assay. Data dideskripsikan dalam bentuk tabel, gambar dan analisa statistik.Hasil : Rerata proliferasi limfosit limpa tertinggi pada kelompok P3, sedangkan rerata proliferasi limfosit limpa terendah pada kelompok K1. Perbedaan bermakna (p<0,005) didapatkan pada P1>K2, P2>K2, dan P3>K2. Perbedaan tidak bermakna ditemukan pada K1-K2, P1-P2, P1-P3 dan P2-P3.Simpulan : Pemberian ekstrak daun Piper crocatum dosis bertingkat selama 14 hari meningkatkan proliferasi limfosit limpa mencit balb/c yang diinfeksi Salmonella typhimurium.Kata Kunci :
Profile of Unilateral Cataract in Pediatric Patients: A 3 Year Retrospective Study: Oral Presentation - Observational Study - Resident Lisana Himmatul Ulya; Liana Ekowati
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/1mq2bb58

Abstract

Abstract Introduction & Objectives : Unilateral cataract presents from 19.6% to 55.5% of pediatric cataract in children by many previous reported studies. This condition is treatable, but delayed treatment may cause visual impairment. This study aims to understand characteristic and treatment of unilateral cataract in children. Methods : The study involved a retrospective review of medical records of patients aged 0-17 years with unilateral cataract who presented to Dr. Kariadi Hospital Semarang from 2019 to 2022. Cases of cataract secondary to causes such as trauma or uveitis were excluded. Results : Thirty-five patient was included in this study, 51% of whom were male and 49% female. The mean age at presentation is 60.49  48.23 months and mean age of onset is 36.77  45.94 months. The most common presenting complaint was whitish eye (81%) while others presented with blurred vision. All the patients had leukocoria, 28% have microcornea, 3% have persistent pupillary membrane. Half of patient (51%) have strabismus, with exotropia being the most common type (34.17%). Eight patients had congenital rubella syndrome, one patient had cytomegalovirus infection while others did not have any systemic condition related to cataract. Majority of patient (17%) treated with phacoaspiration, primary posterior capsulotomy, anterior vitrectomy and intraocular lens implantation. Intraocular lens was implanted in 71% patient and 54% patients given spectacles. Conclusion : Unilateral cataract is disease with isolated and sporadic incident. The majority of patients did not have systemic condition related to unilateral cataract. The most common treatment is phacoaspiration, primary posterior capsulotomy, anterior vitrectomy and intraocular lens implantation.
Co-Authors Akhmad Ismail Liana Ekowati Neni Susilaningsih