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All Journal Jurnal Kedokteran Diponegoro Berkala Ilmiah Kedokteran Duta Wacana
Santoso Jaeri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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THE COMPARISON OF PLASMA MALONDIALDEHYDE LEVELS AMONG OSTEOPOROTIC AND NON-OSTEOPOROTIC POSTMENOPAUSAL WOMEN Innawati Jusup; Putri Theresia LA Bancin; Santoso Jaeri; Banundari Rachmawati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29337

Abstract

Introduction: Osteoporosis is a bone metabolic disorder due to decreased of bone matrix and minerals. Oxidative stress refered as an elevation of reactive oxygen species (ROS) in the cells causing structural damages and functional loss, is contributed in the process of osteoporosis, but its association still in controversy. Herewith we report the comparison of the plasma malondialdehyde (MDA) levels, one of oxidative stress markers among osteoporotic postmenopausal women and without osteoporosis. Methods: An observational analytic study with cross-sectional approach among 40 postmenopausal women, grouped into two groups, osteoporosis (n=20) and non-osteoporosis (n=20) based on bone mineral density (BMD) score. The plasma MDA levels were measured from venous blood using ELISA. The difference between plasma MDA levels among both groups was analyzed using an independent T-test. Results: The characteristics of demography and clinic among both groups are relatively similar. However, there is a difference in the body weight and BMI. Furthermore, there is no significant differences of MDA levels between the two groups (292,03±61,02ng/ml for group with osteoporosis, and 315,25±73,86ng/ml for non-osteoporosis, p=0,286). Conclusions: There is no significant difference in plasma MDA levels among osteoporosis and non-osteoporosis postmenopausal women.
NEUROLOGIC MANIFESTATIONS ASSOCIATED WITH COVID-19 IN PEDIATRIC PATIENTS AT DR. KARIADI HOSPITAL SEMARANG Sareharto, Tun Paksi; Dania Emeralda Firdausy; Santoso Jaeri; Alifiani Hikmah Putranti
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 2 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i2.840

Abstract

Background: Coronavirus Disease-19 (COVID-19), a severe acute respiratory syndrome,  stems from a novel coronavirus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The common symptoms and signs of COVID-19 are fever, cough, diarrhea, and myalgia as well as neurological manifestations. Neurological manifestations of COVID-19 in adult patients have been well recognized, unfortunately, there is limited evidence of neurological manifestations of COVID-19 in children, especially in Indonesia, so herewith we describe neurological manifestations in children, to contribute to the knowledge in the fields of pediatric health and neurology, particularly their correlation with COVID-19. Objective: To determine the neurological manifestations in children with COVID-19. Method: An observational analytic study among 124 pediatric patients with COVID-19 at Dr. Kariadi Hospital Semarang. Demographic and clinical data were obtained from medical records. To determine risk factors for the occurrence of neurological manifestation, the chi-square test, Fisher exact test, and Mann-Whitney U-test were performed. Results: Out of 124 subjects, 49 (39.5%) developed neurological manifestations, including headache (10%), seizure (23%), weakness (5%), dizziness (0.8%), vision impairment (0.8%), ataxia (0.8%), coma (11.3%), paresthesia (0.8%), acute encephalopathy (3.2%), sympathetic storming (0.8%), and others (9.7%). Diagnosis of Multisystem Inflammatory Syndrome in Children (MIS-C) was found in 10 (8.1%) patients, in addition, there was a significant association between the diagnosis of MIS-C, comorbid conditions, and outcomes among patients and neurological manifestations. Conclusion: The most common neurological manifestation experienced by pediatric patients with COVID-19 in this study was seizures. Patients with MIS-C and pre-existing conditions are at higher risk of experiencing neurological manifestations. Children with neurological manifestations more frequently presented with worse outcomes.
Co-Authors Alifiani Hikmah Putranti Banundari Rachmawati Dania Emeralda Firdausy Innawati Jusup Putri Theresia LA Bancin Tun Paksi Sareharto