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All Journal Jurnal Kedokteran Diponegoro Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Albertus Ari Adrianto
Department of Digestive Surgery, Dr. Kariadi General Hospital, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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BREAST CANCER IN PREGNANCY AT DR. KARIADI GENERAL HOSPITAL: A SERIAL CASE Ireneus Vanessa Martono; M. Besari Adi Pramono; Herman Kristanto; Albertus Ari Adrianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29172

Abstract

Background Each year 2.1 million women were diagnosed with breast cancer, being the most common type of cancer found and cancer-related cause of death in women worldwide. In Indonesia, especially in Middle Java, more than 80% women diagnosed were already in the late stage. Physiological changes in pregnancy contributes to the delay in diagnosis in pregnant women and pregnancy also resulted in a more complicated approach of therapy. Regarding only few studies were done involving pregnancy with breast cancer, the aim of the study is to provide further knowledge associated with it.Methods Medical records of pregnant women with breast cancer in year 2014-2018 at Dr. Kariadi General Hospital were studied.Results Based on the 3 cases be studied, patients were referred from class B and C hospitals outside of Semarang city showing stage III (33.33%) and IV (66.67%) breast cancers. Two-third of the patients underwent mastectomy previously and one of them also underwent chemotherapy program prior her pregnancy. Comorbidities varied between patients and therapies were adjusted individually and multidisciplinary. Two of the cases went through transperitoneal caesarean section for delivery and one patient with twin pregnancy died by complications and intrauterine foetal death was also determined.Conclusion Overall, all patients were > 35 years old and the breast cancers were diagnosed at late stage. Complications by comorbidities such as anaemia, severe malnutrition, and infection, were found. Two pregnancies which were already in third trimester was terminated and a case of maternal mortality was found.Keywords Breast cancer, pregnancy
Delayed Right-Sided Traumatic Diaphragmatic Rupture Complicated by Hepatothorax and Visceral Herniation a Decade Post-Trauma: A Case Report Mada Aji Prakoso; Albertus Ari Adrianto; Parish Budiono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1586

Abstract

Background: Traumatic diaphragmatic rupture (TDR) is a rare consequence of high-energy blunt trauma, accounting for less than 1% of all traumatic injuries. Right-sided ruptures are particularly uncommon, representing only 5% to 20% of cases, largely due to the protective anatomical positioning of the liver. Consequently, right-sided injuries are notoriously difficult to detect, often leading to a delayed diagnosis. Case presentation: We present the case of a 29-year-old female who presented with progressive dyspnea ten years after sustaining a motor vehicle collision. Her initial injury was managed as a right-sided hemothorax, with the diaphragmatic defect remaining undetected. A decade later, imaging revealed an elevated right hemidiaphragm with massive herniation of the liver, gallbladder, transverse colon, and omentum into the right thoracic cavity. The patient underwent a successful abdomino-thoracotomy with primary repair of a 10 cm x 4 cm defect, reinforced with a prosthetic mesh. She was discharged on postoperative day seven with an uneventful recovery. Conclusion: This case emphatically highlights the persistent, lifelong risk of delayed visceral herniation following thoracoabdominal trauma. A high index of suspicion must be maintained for patients presenting with delayed respiratory symptoms, as prompt surgical intervention yields excellent outcomes.
Delayed Right-Sided Traumatic Diaphragmatic Rupture Complicated by Hepatothorax and Visceral Herniation a Decade Post-Trauma: A Case Report Mada Aji Prakoso; Albertus Ari Adrianto; Parish Budiono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1586

Abstract

Background: Traumatic diaphragmatic rupture (TDR) is a rare consequence of high-energy blunt trauma, accounting for less than 1% of all traumatic injuries. Right-sided ruptures are particularly uncommon, representing only 5% to 20% of cases, largely due to the protective anatomical positioning of the liver. Consequently, right-sided injuries are notoriously difficult to detect, often leading to a delayed diagnosis. Case presentation: We present the case of a 29-year-old female who presented with progressive dyspnea ten years after sustaining a motor vehicle collision. Her initial injury was managed as a right-sided hemothorax, with the diaphragmatic defect remaining undetected. A decade later, imaging revealed an elevated right hemidiaphragm with massive herniation of the liver, gallbladder, transverse colon, and omentum into the right thoracic cavity. The patient underwent a successful abdomino-thoracotomy with primary repair of a 10 cm x 4 cm defect, reinforced with a prosthetic mesh. She was discharged on postoperative day seven with an uneventful recovery. Conclusion: This case emphatically highlights the persistent, lifelong risk of delayed visceral herniation following thoracoabdominal trauma. A high index of suspicion must be maintained for patients presenting with delayed respiratory symptoms, as prompt surgical intervention yields excellent outcomes.
Co-Authors Besari Adi Pramono Herman Kristanto Ireneus Vanessa Martono Mada Aji Prakoso Parish Budiono