Nelly Nainggolan
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PREVALENCE OF HUMAN PAPILLOMA VIRUS IN CANCEROUS AND PRE-CANCEROUS ORAL LESIONS USING SALIVA, SERUM, AND PLASMA ASSAY Nelly Nainggolan; Wahyu Hidayat
Dentino : Jurnal Kedokteran Gigi Vol 6, No 1 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i1.10641

Abstract

ABSTRACTIntroduction: As many as 90%-95% cases of oral cancer are oral squamous cell carcinoma. In South and Southeast Asia, the prevalence of oral cancer is high. Oral cancer is ranked sixth for the most frequent malignancies in Asia with nearly 274,300 new cases occurring every year. Head and Neck Squamous Cell Carcinoma is one of the main public health concerns with 1-2% incident of all cancers worldwide and is also the sixth most common malignant tumor. Human Papillomavirus (HPV) is a DNA virus which is also known as the cause of head and neck cancer. Among all malignancies, oral cancer is one of the conditions where salivary examination can be used to detect oral cancer because it contacts directly with the lesions. The relationship between human papilloma virus (HPV) and oral squamous cell carcinoma has been extensively studied and shows that HPV-16 & 18 can be detected in saliva, serum or plasma samples and patient biopsies. Purpose: This systematic review aims to reveal the presence of human papilloma virus in cancerous and pre-cancerous lesions of the oral cavity by examining saliva, serum or plasma. Methods: Systematic Review was carried out using the PRISMA method. Articles with clinical trial types sourced from electronic searches were obtained through the PubMed, Research Gate and Google Scholar portals using keywords: Human Papilloma Virus, Oral Cancer, and Saliva. Conclusion: Based on the results, it is concluded that HPV is detected in oral cavity cancers, oropharyngeal, oral squamous cell carcinoma and Oral Potentially Malignant Disorders.Keywords : Human Papilloma Virus, Oral cancer, Saliva
IDIOPATHIC TASTE IMPAIRMENT IN A YOUNG WOMAN: A CASE REPORT Tenny Setiani Dewi; Nelly Nainggolan; Dewi Zakiawati
Dentino : Jurnal Kedokteran Gigi Vol 7, No 2 (2022)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v7i2.14620

Abstract

ABSTRACT  Background: The underlying cause of taste impairment includes damage in the central or peripheral nervous system, nutrition deficiency, systemic disease, or idiopathic. This condition usually occurs with advancing age. Taste alteration may affect the patient’s psychological aspect and causing malnutrition or even develop into more serious health problems. Purpose: This report aims to evaluate an unusual partial ageusia in a young woman and to review articles with idiopathic taste disorders. Case: A 33-year-old woman was referred to the Department of Oral Medicine from the neurology department with a primary diagnosis of migraine and median nerve mononeuropathy. The patient also complained of loss of tastes (salty, bitter, and sour) accompanied by numbness on the palate and left buccal mucosa for the past two weeks. Case Management: The patient was given a 0.12% chlorhexidine digluconate mouthwash and 25 mg zinc tablets twice a day. After 2 weeks, she can identify bitter, and followed by sweet and sour in the next few weeks, as well as improvement of the numbness. Eighteen studies of idiopathic taste disorders from 1991-2021 have been reported in the literature. Conclusion: Taste disorders with unknown aetiology may happen in young individuals. Zinc has been proven as a beneficial micronutrient to treat patients with idiopathic taste impairment. Dentists should consider this approach to resolve the symptoms and accelerate the healing process of possible co-occurrence systemic diseases.  Keywords: Ageusia, idiopathic, Taste dysfunction, Treatment
Peranan Dokter Gigi dalam Meningkatkan Kualitas Hidup Pasien Mukositis dengan Leukemia Limfoblastik Akut (Laporan Kasus) Theodora Adhisty Dwiarie; Nanan Nur’aeny; Nelly Nainggolan
Denta Journal Kedokteran Gigi Vol 16 No 1 (2022): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v16i1.2

Abstract

Background: Mucositis, a painful condition common in patients undergoing chemotherapy, can decrease the patient's quality of life. Treatment of mucositis by dentists supports the improvement of general health conditions and the patient's quality of life. This case report aims to discuss a case of a patient with mucositis after undergoing chemotherapy treatment for acute lymphoblastic leukemia. Case: 21 years old female diagnosed with acute lymphoblastic leukemia, referred to the oral medicine department from internal medicine, complained of pain in oral mucosa and lockjaw in the last three days after chemotherapy treatment with methotrexate. Internal medicine prescribes ceftriaxone intravenous (IV), dexamethasone IV, chlorhexidine gargle, and nystatin. Intraoral examination showed erosive lesions in the tongue, labial, and buccal mucosa and was diagnosed as oral mucositis grade 3 according to the World Health Organization scale. Her quality-of-life score is 46 according to The Functional Assessment of Cancer Therapy-General (FACT-G) and 58 according to Oropharyngeal Mucositis Quality of Life (OMQoL). Case management: She was treated with magic mouthwash containing diphenhydramine HCL, sucralfate, and aluminum hydroxide-magnesium hydroxide. Chlorhexidine and nystatin were advised to stop. The patient was instructed to keep her oral hygiene by gargling with sodium chloride and povidone-iodine after eating. Five days after the therapy, her condition improved (grade 1), and there was an increase in the FACT-G and OMQoL scores to 54 and 93. Conclusion: Mucositis can cause pain in the patient. A dentist can help diagnose and provide appropriate treatment to reduce the patient's complaints and improve the patient's quality of life.