Article Per Year (5 Year)
p-Index From 2020 - 2025
0.61
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Bandung
Linda Chiuman
Faculty of Medicine, Universitas Prima Indonesia, Medan
Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Correlation Between Blood Glucose and Estradiol Levels in Women in Reproductive Age David Lionardi; Chrismis Novalinda Ginting; Linda Chiuman
Majalah Kedokteran Bandung Vol 52, No 3 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n3.2079

Abstract

Type 2 Diabetes mellitus (Type 2 DM) is a metabolic disorder characterized by an increase in blood sugar caused by decreased insulin secretion by pancreatic beta cells and/or impaired insulin function (insulin resistance). This study aimed to determine the specific levels of estradiol hormone in reproductive age women with diabetes mellitus in different age groups. This was an analytical study in  September at Royal Prima Hospital, North Sumatra, Indonesia. Twenty women participated in this study after informed consent and were divided into two age groups: 40–45 years old and 46–50 years old.  Blood samples were collected after 10-12 hours of fasting to assess blood sugar and estradiol hormone levels. Data were then analyzed using the dependent t-test dependent and compared. No significant difference in blood sugar level was found between the two age groups (p-value=0.113, p-value> 0.05) that there were no significant differences in blood sugar levels between the two age groups. The estradiol hormone level in the age group 40-45 years was lower than in the age group 46–50 years, and the difference was significant (p-value =0.000, p-value<0.05). No significant correlation was seen between type 2 DM and estradiol hormone level in this study. In conclusion, age is not the main contributing factor for the increase and decrease in blood sugar level, and type 2 DM does not correlate with estradiol hormone. Hubungan Antara Kadar Glukosa Darah dengan Kadar Estradiol Pada Masa ReproduktifDiabetes mellitus (DM) Tipe 2 adalah penyakit gangguan metabolik yang ditandai oleh kenaikan gula darah akibat penurunan sekresi insulin oleh sel beta pankreas dan atau ganguan fungsi insulin (resistensi insulin). Penelitian ini bertujuan mengetahui kadar hormon estradiol wanita reproduktif yang menderita diabetes mellitus pada kelompok usia yang berbeda. Penelitian ini merupakan penelitian analitik yang dilakukan di bulan September di Rumah Sakit Royal Prima, North Sumatera, Indonesia. Sebanyak 20 wanita berpartisipasi dalam penelitian ini setelah mendapat persetujuan dan dibagi atas dua kelompok usia, 40–45 tahun dan 46–50 tahun. Sampel darah diambil setelah 10-12 jam puasa untuk menilai kadar gula darah dan hormon estradiol. Data kemudian dianalisis menggunakan t-test dependent dan dibandingkan. Tidak ada perbedaan kadar gula darah yang signifikan antara kedua kelompok usia (p=0.113; p>0.05) sehingga tidak ada perbedaan kadar gula darah yang bermakna antara kedua kelompok tersebut. Kadar hormon estradiol pada kelompok usia 40–45 tahun memiliki kadar estadiol lebih rendah dibanding dengan kelompok usia 46–50 tahun. Tidak terdapat korelasi antara DM tipe 2 dan hormon estradiol yang bermakna pada  penelitian ini.. Simpulam, bahwa usia bukan merupakan faktor penyebab utama peningkatan dan penurunan kadar gula darah dan DM tipe 2 tidak berhubungan dengan hormon estradiol.
White Turmeric Rhizome Protection Effect of against Lung Tissue Damage in Copper Sulfate-Induced Wistar Rats Linda Chiuman; Fahrul Azmi Tanjung; Djamin Djamin
Majalah Kedokteran Bandung Vol 53, No 1 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n1.2211

Abstract

One of common heavy metals that pollute rivers in Indonesia is copper, which can damage various organs, including the lungs. As a potential natural herbal medicine, white turmeric rhizome has antioxidant properties that potentially protect the body from copper pollution. This study aimed to explore the potential of the white turmeric rhizome (Curcuma zedoaria) to provide a protective effect on the lungs against copper contamination. This study was an experimental study performed in June 2020 on 25 copper-induced Wistar rats which were divided into five groups: negative group that received 1 ml of copper sulfate suspension at the 12th to 14th day; positive group that received 10 mg/200 g BW of ethanol extract from white turmeric without copper sulfate suspension; and three experimental groups that received 10 mg/200 gBW, 20 mg/200 gBW, and 40 mg/200 gBW of ethanol extract from white turmeric every day, respectively, followed by copper sulfate suspension at the 12th–14th day. After 14 days, the rats were sacrificed by chloroform inhalation and the lung was excised and processed for histopathology preparation. The edema, hemorrhage, leukocyte infiltration, and alveolar septal thickness were evaluated from the lung tissue perparation. The score of tissue damage was express as median (Range) and analyzed using the Kruskal-Wallis test. The result of this study shows that there was a significant difference in lung tissue score among all groups of treatment (p-Value=0.001). The experimental group with highest dosage extract presented a good protection effect as well as the positive group. Hence, white turmeric has a good protective property for the lung against damages caused by copper contamination.
Effects of Ethanolic Extract of Curcuma Longa on Cardiac Biomarkers of Doxorubicin-Induced Rats Lydia Ernawati Rahayu; Linda Chiuman; Chrismis Novalinda Ginting; Sahna Ferdinand Ginting
Majalah Kedokteran Bandung Vol 52, No 4 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2121

Abstract

Cardiotoxicity is a condition where damages caused by toxic chemical exposure are observed in heart and blood vessels. Doxorubicin is the most common chemotherapy agents for various types of cancer therapy. However, doxorubicin is converted into doxorubicinol known to trigger cardiac disfunctions and release of several cardiac biomarkers, such as CK-MB and LDH. Turmeric is known to be an alternative medical treatment that has the effect of neutralizing oxidative stress. This study aimed to evaluate CK-MB and LDH levels in doxorubicin-induced rats (20 mg/kgBW) that received turmeric ethanolic extract from curcuma. This was an experimental study conducted in February 2020 in the Faculty of Pharmacy Universitas Sumatera Utara. The rats were divided into six group and each group consisted of wistar albino male rats. The groups were normal (CMC-Na), positive control (Vitamin E 1%+Dox 20 mg/kgBW), negative control (Dox 20 mg/kgBW), treatment I (EEC 100 mg/kgBW+Dox 20 mg/kgBW), treatment II (EEC 300 mg/kgBW+Dox 20 mg/kgBW), and treatment III (EEC 500 mg/kgBW+Dox 15 mg/kgBW). Doxorubicin was given 5 mg/kgBW once a week for four weeks. Results showed that the groups that received 100 mg/kg BW, 300 mg/kgBW, and 500 mg/kgBW of turmeric ethanol extract demonstrated a reducing effect on the biomarkers of cardiac damage, i.e. CK-MB and LDH. Statistically, serum CK-MB and LDH levels at dose 500 mg/kgBW showed no significant differences (p>0.05) with the normal and positive treatment group. In conclusion, turmeric has a cardioprotective effect. Pengaruh Kardioprotektif Ekstrak Etanol Curcuma Longa pada Tikus yang Diinduksi DoxorubicinKardiotoksisitas adalah kondisi terjadinya jantung dan pembuluh darah akibat paparan kimia. Doxorubicin diubah menjadi doxorubicinol yang diketahui menyebabkan gangguan fungsi jantung dan pelepasan biomarker jantung sseperti CK-MB dan LDH. Kunyit dikenal sebagai pengobatan alternatif yang memiliki efek menetralkan stres oksidatif. Penelitian ini dilakukan pada Februari 2020 di Fakultas Farmasi Universitas Sumatera Utara. Tujuan penelitian ini adalah mengevaluasi kadar CK-MB dan LDH pada tikus yang diberi ekstrak etanol kunyit yang diinduksi doksorubisin (20 mg/kgbb). Penelitian dibagi menjadi enam kelompok dan tiap-tiap kelompok terdiri atas 4 ekor tikus wistar albino jantan: normal (CMC-Na), kontrol positif (Vitamin E 1%+Dox 20 mg/kgBB), kontrol negatif (Dox 20 mg/kgBB), group I (EEC 100 mg/kgBB+Dox 20 mg/kgBB), group II (EEC 300 mg/kgBB+Dox 20 mg/kgBB), dan group III (EEC 500 mg/kgBB+Dox 15 mg/kgBB). Doxorubicin 5 mg/kgBB diberikan 4 kali. Hasil penelitian menunjukkan bahwa kelompok yang diberi ekstrak etanol kunyit dengan dosis 100 mg/kgBB, 300 mg/kgbb, 500 mg/kgBB memiliki efek penurunan biomarker kerusakan jantung yaitu CK-MB dan LDH. Berdasar atas hasil uji statistik kadar CK-MB dan LDH serum pada dosis 500 mg/kgBB tidak terdapat perbedaan yang bermakna (p>0,05) dengan kelompok normal dan positif, dapat disimpulkan bahwa kunyit memiliki efek kardioprotektif.
Co-Authors Chrismis Novalinda Ginting David Lionardi Djamin Djamin Fahrul Azmi Tanjung Ginting, Chrismis Novalinda Lydia Ernawati Rahayu Sahna Ferdinand Ginting