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All Journal Majalah Kedokteran Bandung Science Midwifery
Amelya Permata Sari
Master Program In Midwifery, Faculty Of Medicine, Universitas Andalas
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Gestational Monosodium Glutamate Exposure Effects on Anogenital Distance of Male Rat Pups Amelya Permata Sari; Cimi Ilmiawati; Mohamad Reza
Majalah Kedokteran Bandung Vol 53, No 2 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n2.2302

Abstract

High-dose Monosodium Glutamate (MSG) expo sure increases the estrogen level in pregnant rats. However, there are limited data available on whether the MSG-related maternal hormonal effects can affect male litters' genitalia phenotype. This study aimed to analyze the impact of MSG on estrogen level in pregnant rats and anogenital distance in male pups. Experiment for this study was performed at the animal facility of Biomedical Laboratory at the Faculty of Medicine, Universitas Andalas, from April 2019 to February 2020. Pregnant Wistar rats were given MSG orally at 2 and 4 mg/g body weight (BW) for 20 days. On day 21, pregnant rats were sacrificed and blood was drawn intracardially. Estradiol serum level was measured by ELISA. Male pups were counted, and the anogenital distance (AGD) was measured. Maternal serum estradiol levels were statistically analyzed by One-Way ANOVA and the AGD of male litters were analyzed by the Kruskal-Wallis test. Results showed that perinatal MSG exposure increased the estradiol level (26.3±4.5 pg/ml; 37.5±6.7 pg/ml; 62.1±8.2 pg/ml in control, 2 mg/g BW, and 4 mg/g BW group, respectively [mean±SD; p=<0.001]) and decreased the AGD (4 mm; 3 mm; 1.5 mm in control, 2 mg/g BW, and 4 mg/gBW group, respectively [median; p=<0.01]) in a dose-dependent manner. Thus, MSG exposure during pregnancy is a risk factor for male rat feminization. 
The Effect of Monosodium Glutamate on Estradiol Levels in Pregnant Rats Amelya Permata Sari; Rika Susanti
Science Midwifery Vol 9 No 2 (2021): April: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

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Abstract

Monosodium glutamate (MSG) is a form of the glutamic acid salt. The purpose of this study to analyze the effect of MSG on estrogen levels in pregnant rats. This research is an experimental study was conducted at January in the Biomedical Laboratory of the Faculty of Medicine, Andalas University, Padang. Total of samples consist of 18 pregnant Wistar rats which were divided into three groups, namely control, treatment one and treatment two. Blood sampling and surgery were performed on day 20 to assess male estrogen levels. Estrogen levels were measured by using the One Way ANOVA. There were significant differences on serum estrogen levels between the control group and treatment group one (p = 0.012) and treatment two (p <0.01) and between treatment group one and treatment group two (p <0.001).The conclusion, there is an effect of MSG on estrogen levels in pregnant rats.
Co-Authors Ilmiawati, Ilmiawati Mohamad Reza Rika Susanti