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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kimia Terapan Indonesia Chemistry and Materials Jurnal Sains Materi Indonesia
Marissa Angelina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology

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EKSTRAK TERSTANDAR SECARA KIMIA DAUN Brucea javanica Merrill Marissa Angelina; Abdul Mun'im; M Hanafi
Jurnal Kimia Terapan Indonesia Vol 13, No 2 (2011)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4677.355 KB) | DOI: 10.14203/jkti.v13i2.143

Abstract

The preparation of Brucea leaves have been done for specific parameters and non specific parameter laboratory worb refers to TheNational Agency of Drug and Food Control Regulation for extract quality control. The result for specific extract parameters  were the rendement of extraction is 28%, the values of water- extractive and ethanol-extractive are 11.49% and 9.41%,  respectively. The result of determination of the non specific  parameters of the extract are; loss on drying is 18.95%, the  water content is 15.06%, the total ashes is 16.12%. and the  level of ashes not dissolved in acid is 11.14%. The analysis of chemical compound shows that the extract containedflavonoid,  tannin, and glycoside. For the quantitative control has been measured the level of totalflavonoid wherethe result is 9.901%Keywords : Preparation, Brucea; Specific parameter, non specificparameter, extract
ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF Selaginella plana HIERON. ON T47D CELL LINE IN VITRO Chandra Risdian; Sri Handayani; Zalinar Udin; Rina Andriyani; Marissa Angelina
Jurnal Kimia Terapan Indonesia Vol 13, No 2 (2011)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3718.065 KB) | DOI: 10.14203/jkti.v13i2.153

Abstract

Selaginella sp belongs to the Selaginellaceae family. It has been used in China and Indonesia as a traditional medicine. It hasseveral medicinal properties including antibacterial, anticardiovascular, and anticancer agent. The aim of the present study was to access the anticancer property of the ethanolic  extracts of Selaginella plana Hieron. on T47D breast cancer cell line. The proliferation of T47D cell line was detected by SRB (Sulforhodamine B) assay which was measured at a wavelength of 515 nM. The result showed that the IC50 of the ethanolic extract was determined at 7.03 pg/mL. This significant activity was assumed due to its high total flavonoid content. The totalflavonoid content of the ethanolic extract was 23.04%. Flow cytometry analysis indicated that the extract may undergo the cell death via apoptosis pathway. In conclusion, the ethanolic extract of Selaginella plana Hieron: has considerable activity in inhibiting T47D cell line proliferation.Key words: Selaginella plana Hieron., SulforhodamineB, T47Dcells, anticancer flow cytometry
Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice Marissa Angelina; Indah D Dewijanti; Banjarnahor S D S; Megawati megawati; Tri Yuliani
Journal of Tropical Life Science Vol. 2 No. 2 (2012)
Publisher : Journal of Tropical Life Science

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Abstract

The objective of the study was to evaluate the oral acute toxicity of Brucea javanica Merril extract on both Male and Female DDY-Mice. Brucea javanica leaves have activity as a cytotoxic, anti-diarhhea, etc. Brucea javanica leaves extract was administered orally for first 24 hours at various dose levels (562.5mg/kg bw, 1125 mg/kg bw, 2250 mg/kg bw, and 4500 mg/kg bw) to determine the toxicity effects. The treatment groups were compared to the normal control. Vital organs (liver, heart, lymph, lungs, etc) and body weight were analyzed to study the toxicity. LD50 determined using Reed and Munich formula. Vital organs average weight showed no difference between control group and treatment groups from the lowest dose until the highest dose. In addition, the body weight data showed no difference between control group and treatment groups. LD50 for Brucea javanica extract using Reed and Munich formula was 1003.65 mg/kg bw. The result of the study showed that extract were categorized as lightly toxic.Keywords: Acute toxicity, Brucea javanica Merril, DDY-Mice, LD50
Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Sofna Dewita Sari Banjarnahor; Indah D Dewijanti; Marissa Angelina; Megawati Megawati; Sofa Fajriah
Journal of Tropical Life Science Vol. 5 No. 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
Formulation and Characterization of Dewandaru Fruit Extract in Nanocarrier System Melati Septiyanti; Nurfauziyah; Marissa Angelina; Rizna Triana Dewi; Sofa Fajriah; Yenny Meliana
Jurnal Sains Materi Indonesia Vol. 25 No. 2 (2024): Jurnal Sains dan Materi Indonesia
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jsmi.2024.3121

Abstract

Dewandaru (Eugenia uniflora L.) is a herbaceous plant that grows in tropical and subtropical regions. The fruit extract can prevent oxidative damage and cholinergic changes. It contributes to antihyperglycemic, antihyperlipidemic, and neuroprotective due to its antioxidants and antidepressant effect. It also possesses antibacterial and anti-inflammatory activity and potentially prevents cardiovascular disease and cancer. In this study, dewandaru fruit extract was formulated in the nanocarrier system (nanoemulsion and nanoencapsulation) to preserve product stability and improve product dispersibility and bioavailability. The nanoemulsion optimum formulation condition was obtained on dewandaru fruit extract concentration 10 wt%, oil/surfactant ratio 0.25, and homogenization speed 20.000 rpm, resulting in particle size of 46.4 ± 0.4 nm and polydispersity index 0.480 ± 0.015. The optimum nanoemulsion formulation was further processed to nanoencapsulation along with milling to produce finer particles. The nanoencapsulation milled for 120 minutes produced encapsulation powder with a size of 5.8 ± 3.340 μm. Accordingly, the nanocarrier technology for dewandaru fruit extract promoted a versatile medicinal preparation both in liquid and solid form. However, the size reduction by milling might disrupt the efficiency of the encapsulation release system. Without the proper coating, as orally administrated, the compound rapidly dissolved before it reached the targeted site.
The The Effect of Electrodeposition Voltage on the Antioxidant Activity of Gold Nanoparticles Suliasih, Babay Asih; Sakinah, Anis; Marissa Angelina
Chemistry and Materials Vol. 3 No. 1 (2024)
Publisher : Pusat Inovasi Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56425/cma.v3i1.72

Abstract

Gold nanoparticles (AuNPs) are well known as free radical scavengers, which may induce cell damage, triggering degenerative diseases and premature aging. This research aims to assess the antioxidant activity of AuNPs synthesized via the electrodeposition method, employing cyclic voltammetry on a Fluorine-doped Tin Oxide (FTO) substrate. By varying the initial voltage, the resulting AuNPs exhibit  variations in both particle size and number. In this study, AuNPs demonstrated promising antioxidant potential, particularly at an initial voltage of -1 V, as evidenced by their ability to respond to DPPH radicals, yielding a percent inhibition of up to 36.80%.
Co-Authors Abdul Mun'im Anis Sakinah, Anis Banjarnahor S D S Chandra Risdian Indah D Dewijanti Indah D. Dewijanti Lia Meilawati M Hanafi Megawati Megawati Melati Septiyanti Nurfauziyah Rina Andriyani Rizna Triana Dewi Sofa Fajriah Sofna D.S. Banjarnahor Sofna Dewita Sari Banjarnahor Sri . Handayani Sri Hartati Suliasih, Babay Asih Tri Yuliani Yenny Meliana Zalinar Udin