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All Journal Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Ilmiah Kesehatan Parapemikir Jurnal Ilmiah Farmasi
Agustina Putri Pitarisa S
Sekolah Tinggi Ilmu Farmasi Nusaputera
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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OPTIMASI FORMULA PEEL-OFF EKSTRAK ETANOL 70% BUNGA ROSELA (Hibiscus Sabdariffa L.) DENGAN KOMBINASI CARBOMER DAN POLIVINIL ALKOHOL Nurista Dida Ayuningtyas; Agustina Putri Pitarisa Sudarsono; Azizah Yuka Hapsari
Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Vol 8 No 2 (2017)
Publisher : STIKES BHAMADA SLAWI

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Abstract

Hibiscus sabdariffa L. dikenal dengan nama bunga Rosela merupakan tanaman yang banyak ditemukan di Indonesia dan memiliki banyak manfaat untuk kesehatan. Kandungan polifenol yang tinggi pada bunga Rosela telah banyak dimanfaatkan sebagai antioksidan untuk menangkal radikal bebas. Pada penelitian akan dilakukan optimasi masker peel off menggunakan design of experiment 7.0.0 metode simplex latice design dengan membandingkan polimer carbomer dan polivinil alkohol. Pengujian masker peel off yang dilakukan yaitu uji organoleptis, homogenitas, daya sebar, daya lekat, pH, dan uji viskositas. Persamaan hasil uji yang diperoleh dapat digunakan untuk melihat persamaan hubungan antara komposisi polimer dengan hasil uji. Formula optimum diperoleh berdasarkan analisis software design of experiment 7.0.0. Hasil uji organoleptis yang diperoleh dari run 1-13 berbentuk semi padat dan berwarna merah kecoklatan. Peel-off yang terbentuk homogen dengan nilai daya sebar 14,14-24,93 cm2, memiliki daya lekat dalam range 12,47–36,41 detik, nilai pH berkisar 4,213-4,88, viskositas 120 –250 dPas, hasil uji responden diperoleh antara 18,25-19,10 dan uji waktu pengeringan peeloff 6,02-11,30 detik. Formula optimum peel off ekstrak etanol 70% bunga Rosela diperoleh dengan kombinasi carbomer dan PVA 1 : 4 %.
Optimization Of Formula SNEDDS Mahogany Seed Oil (Swietenia mahagoni (Linn.)) with Simplex Lattice Design Method Nurista Dida Ayuningtyas; Agustina Putri Pitarisa S; Silmi Mey Aryani
Jurnal Ilmiah Kesehatan Vol. 15 No. 1 (2022): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/jiks.v15i1.626

Abstract

Mahogany seed oil has antimicrobial, antihypertensive, antidiabetic and anti-inflammatory activities. This activity can be developed in SNEDDS dosage form. SNEDDS can deliver lipophilic drugs to the target side of the drug. SNEDDS has oil components, surfactants, and co-surfactants. In this study, optimization of the SNEDDS formula with the SLD method will be carried out. The oil components tested were oleic acid, VCO and HDI; surfactants namely Cremophor RH40 and Tween 80; and co-surfactant components, namely PEG 400 and propylene glycol. The tests for SNEDDS were transmittance, pH, and emulsification time. The results of the evaluation were analyzed to obtain the optimal formula and determined the loading dose. The next test was to determine the particle size and zeta potential to see the stability of SNEDDS mahogany seed oil. Result : Optimal formula composition obtained oleic acid 1,00 Cremophor RH 40 7,89 and PEG 400 1,11 with desirability value 0,988. Loading dose of mahogany seed oil obtained 800 l with a transmittance value of 99,3 % + 0,44 ; pH 5,06 + 0.63 , and emulsification time 74,04 + 6,05 seconds. SNEDDS mahogany seed oil measuring 17,7 nm + 0,3 with a potential zeta value of -22,67 mV + 0,47. SNEDDS mahogany seed oil obtained belongs to Grade A where SNEDDS quickly forms nanoemulsions in 1 minute, has a clear appearance.
Formula Optimization of Sunscreen Lotion Leaves Muntingia calabura L. Extract Nurista Dida Ayuningtyas; Agustina Putri Pitarisa S; Rizqi Adi Irfani
Parapemikir : Jurnal Ilmiah Farmasi Vol 11, No 1 (2022): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v11i1.2290

Abstract

Background : sunlight contains ultraviolet that happened skin problem from mild to severe. To overcome these problems, a sunscreen made from natural materials is relatively safe. CKersen Leaves (Muntingia calabura L.) contain total flavonoids and phenolics can be used as active ingredients. In lotion preparations, emulsifiers can affect the physical properties of lotions. Objective : from this research is to study the optimal emulgator composition of stearic acid and triethanolamine in 70% ethanol extract of Kersen Leaves. Method :  stearic acid and triethanolamine will be optimized using Software Design Expert version 11 Simplex Lattice Design method. Formula was evaluated using organoleptic, homogeneity, pH, dispersibility, adhesion, and viscosity. Result : showed that 8 run of 70% ethanol extract of lotion leaves of Kersen (muntingia calabura L.) were homogeneous, had a brown color, typical odor of greentea with a pH of 6.64-8.06; spread capacity 5.32-6.18 cm; adhesion of 3.85-15.37 seconds and viscosity of 2000-3100 cp. Conclusion : optimal formula for lotion preparations obtained stearic acid 3.31% : triethanolamine 2.69%. T test results show the equation that applies to the pH response, adhesion and viscosity.
Co-Authors Ayuningtyas, Nurista Dida Azizah Yuka Hapsari Rizqi Adi Irfani Silmi Mey Aryani Tri Mulyani Widyawati, Erni