Mia Melinda
Laboratorium Ilmu Penyakit Dalam Rumah Sakit Umum Daerah Dr . Saiful Anwar Malang

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Efikasi Kombinasi Rebamipide dengan Lansoprazole pada Proses Penyembuhan T ukak Lambung Tikus yang Dipapar Indometasin Melinda, Mia; Ahmad, Harijono
Jurnal Kedokteran Brawijaya Vol 26, No 3 (2011)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.145 KB) | DOI: 10.21776/ub.jkb.2011.026.03.7

Abstract

Gastropati  akibat  penggunaan  NSAID  masih merupakan  permasalahan  kesehatan  di  Indonesia  dengan  standar  terapi lansoprazol  yang  menekan  produksi  asam  di  lambung.  Disisi  lain  pemberian  NSAID  menginduksi  kerusakan  mukosa dengan menghambat faktor defensive  mukosa, sehingga dapat dikelola dengan obat yang menghambat proses inflamasi yaitu  rebamipide.  Studi  dilakukan  untuk  mengidentifikasi  efektifitas  kombinasi  lansoprazol  dan  rebamipid  dibanding penggunaan  tunggal.  Desain  experimental  post  test  only  group  dilakukan  pada  empat  kelompok  perlakuan  yaitu  1) kelompok  kontrol  positif  dengan  induksi  indometasin,  2)  rebamipid,  3)  lansoprazol,  dan  4)  kombinasi.  Pengamatan dilakukan  pada  jam  ke  12,  24,  36  dan  48  jam  untuk  mengetahui  ukuran  dan  derajat  ulkus  (kriteria  Dixon),  jumlah  VEGF  dan MVD dan dianalisis menggunakan uji One Way ANOVA.  Semua terapi dapat  memperbaiki ulkus dengan efek tercepat  (24 jam)  pada  terapi  lansoprazol  saja  diikuti  terapi  kombinasi.  Secara  histologi  pemberian  terapi  lansoprazol  memberikan gambaran normal pada jam  ke 48. Ekspresi VEGF dan MVD meningkat pada semua kelompok sejak jam  ke 12, dengan jumlah  tertinggi  pada  kelompok  terapi  lansoprazol.  Dapat  disimpulkan  penambahan  rebamipid  tidak  mempercepat proses  kesembuhan  dibandingkan  terapi  tunggal  lansoprazol. Kata  Kunci:  NSAID,  lansoprazole,  rebamipide
ANTIBIOGRAM STUDY AND ANTIBIOTIC USE EVALUATION USING GYSSEN METHOD IN PATIENTS WITH DIABETIC FOOT Fadlilah, Umul; Hasmono, Didik; Wibisono, Yudi Agung; Melinda, Mia
Folia Medica Indonesiana Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.327 KB) | DOI: 10.20473/fmi.v52i3.5452

Abstract

Foot infection is a common and serious problem in people with diabetes, which require proper management (diagnostic and therapeutic approaches) that can be cured. Empiric antibiotic regimen should be based on clinical data and bacteria pattern that are available, but definitive therapy should be based on the results of the infected tissue culture. The selection of initial antibiotic therapy was difficult and unwise use can lead to antibiotic-resistant. Evaluation is needed for using antibiotics to benefit wisely. The aim of this research is to analyzed the pattern of bacteria in diabetic foot and to its sensitivity test to antibiotics, analyze empiric antibiotics that can be recommended, and analyzed the use of antibiotics by Gyssen method. Data was analyzed with observational studies (descriptive non-experimental), retrospectively and prospectively in patients diabetic foot infection that met inclusion criteria. Retrospective data are used to analyzed bacteria pattern and its sensitivity test, while prospective data are used to evaluated the use of antibiotics based on bacteria pattern, during the period of late March-early August 2015 at Mardi Waluyo Hospital. Evaluation was conducted by Gyssen method. The results, retrospective data samples obtained 30 infection bacteria during August 2014-March 2015. The prevalence of gram-negative bacteria as 53.33% with most types of bacteria E.coli and Klebsiella oxytoca (13.33%), and gram-positive bacteria as 46.67% with the highest bacteria are Staphylococcus spp. and Streptococcus spp. From the prospective data in inclusion criteria, 13 patients with the highest prevalence of gram-negative bacteria are Klebsiella oxytoca (28.57%), and most gram-positive Staphylococcus auerus (35.71%). While the qualitative analysis of antibiotic use was conducted on 50 types of antibiotics. The results of the qualitative analysis using Gyssens method obtained category as 62%, 2%, 14%, 2B category as 26%, 3A category as 10%, 4A category 52%, 4B category as 6%, 4C category as 8% and there are no use of antibiotics in the category V and VI. Conclusions, Gyessen method can show that the use of antibiotics in diabetic foot patients in Mardi Waluyo hospital is dominated by inaccuracy in choice of antibiotic, and inaccuracies in the interval antibiotics.