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All Journal Alchemy : Journal of Chemistry Jurnal Kimia Riset Walisongo Journal of Chemistry
Novrynda Eko Satriawan
Department Of Chemistry, Faculty Of Science And Technology, Annuqayah Institute Of Science And Technology
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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IDENTIFIKASI DAN UJI RESISTENSI Staphylococcus aureus TERHADAP ANTIBIOTIK (CHLORAMPHENICOL DAN CEFOTAXIME SODIUM) DARI PUS INFEKSI PIOGENIK DI PUSKESMAS PROPPO Ratno Budiyanto; Novrynda Eko Satriawan; Asdwi Suryani
Jurnal Kimia Riset Vol. 6 No. 2 (2021): Desember
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v6i2.30694

Abstract

Pemberian antibiotik pada pasien yang mengalami infeksi piogenik pada kulit di puskesmas proppo belum berdasarkan pada pola kuman dan sensitifitas antibiotik. Penelitian ini bertujuan untuk mengidentifikasi, isolasi serta uji sensitifitas bakteri terhadap beberapa antibiotik sehingga dapat diketahui jenis antibiotik yang paling paten untuk bakteri Staphylococcus aureus. Hasil pengamatan pada isolat pus menunjukkan adanya Staphylococcus aureus dengan ciri kesesuaian. Agar diperoleh bakteri murni dengan jumlah maksimum maka dilakukan isolasi. Telah berhasil diisolasi dan diidentifikasi ke-4 isolat pus yang tumbuh dan memfermentasi pada plat mannitol salt agar, sel berbentuk bulat bergerombol dan bersifat gram positif baik melalui pewarnaan maupun uji secara biokimia. Hasil uji terhadap Chloramphenicol memiliki nilai rata-rata daya hambat 24.0 mm dengan persentase penggunaan mencapai 75.0 %, sedangkan untuk Cefotaxime sodium memiliki nilai rata-rata zona hambat 10.9 mm dengan persentase penggunaan mencapai 25.0 %. Dapat disimpulkan bahwa ke-4 isolat tersebut kesemuanya diidentifikasi sebagai Staphylococcus aureus dengan zona hambat masing-masing isolat sebesar 23.5 mm, 24.2 mm, 24.0 mm dan 24.3 mm yang menunjukkan sensitif terhadap Chloramphenicol sedangkan zona hambat terhadap Cefotaxime sodium masing-masing isolat adalah 5 mm, 10.5 mm, 14.5 mm dan 13,5 mm yang menunjukkan resisten terhadap penggunaan antibiotik tersebut.
Synthesis and Characterization of Cellulose–Curcumin Nanofiber as a Biomaterial Mask Novrynda Eko Satriawan; Muhamad Nasir; Fasih Bintang Ilhami
Walisongo Journal of Chemistry Vol 5, No 1 (2022): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v5i1.9628

Abstract

This study was conducted to characterize cellulose acetate-curcumin composite nanofibers synthesized using the electrospinning method, as a biomaterial mask with antibacterial and antiviral properties. Cellulose acetate-curcumin composite nanofibers were successfully synthesized at a flow rate of 1 mL/hour, a needle-collector distance of 17 cm, and a voltage of 22 kV. The resulted nanofibers have an average diameter in the range of 378.89 nm - 461.76 nm. Based on the results of the FTIR spectrum, no significant shift was found. The results of the contact angle test showed that the average contact angle value increased with the addition of curcumin concentration. The mechanical test results showed that variations in the concentration of curcumin were able to increase the tensile strength and strain values.
Fabrication and Characterization of Ibuprofen and Ceftriaxone loaded Electrospun Cellulose Acetate Nanofiber Layers as a Model of Targeted Drug Delivery System Novrynda Eko Satriawan; Junaidi Khotib; Muhamad Nasir; A. H. Zaidan
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.15502

Abstract

This study aims to study the process of fabricating and characterization nanofibers based on cellulose acetate polymer filled with ceftriaxone and ibuprofen using the electrospinning method as a model for a targeted drug delivery system. Cellulose acetate has been successfully fabricated into nanofibers using the electrospinning method and filled with ceftriaxone and ibuprofen. The resulting nanofibers have an average diameter in the range of 412.5 – 558.5 nm under the conditions of the electrospinning process, namely 22 kV voltage, 15 cm distance, and flow rate. 0.005 mL/min using acetone/DMAc (2:1). Based on the data generated from the FTIR test, homogeneity, and drug release test, it is known that the resulting nanofibers, namely cellulose acetate, cellulose acetate-ceftriaxone, and cellulose acetate-ibuprofen, have good morphological characteristics, homogeneity, and release rate so that they have the potential to be used as a targeted drug delivery system
THE FABRICATION OF TEST STRIP FOR SIBUTRAMINE HCl DETECTION IN SLIMMING TRADITIONAL HERBAL MEDICINE Robi'atul Andawiyah; Novrynda Eko Satriawan; Jumaati
Jurnal Kimia Riset Vol. 8 No. 1 (2023): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v8i1.41110

Abstract

The development of an optical sensor-based test strip for the detection sibutramine HCl adulteration in traditional herbal products has been studied. The medium of the test strip was cellulosic paper immobilized with Dragendorff’s reagent and tetraethyl orthosilicate (TEOS) as the precursor using the sol-gel method. The presence of sibutramine HCl changed the color of the test strip from yellow to orange-red. The change in color was scanned and converted to RGB values using the ImageJ software. The intensity of the RGB value correlates with the concentration of the analyte. The performance of the test strip had good linearity in the range of 0,1-1,5 mM of sibutramine HCl, and the correlation coefficient (R) was 0,9872. The limit of detection, limit of quantification, precision (% RSD), and percentage of accuracy were 0,2 mM, 0,8 mM, less than 5%, and approximately 80-90%, respectively. The strip test is low cost and simple. Thus, it can be used as an alternative to detect sibutramine HCl in traditional herbal products.
Co-Authors A. H. Zaidan Asdwi Suryani Fasih Bintang Ilhami Jumaati Junaidi Khotib Muhamad Nasir Muhamad Nasir Ratno Budiyanto Robi'atul Andawiyah