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All Journal Dental Journal (Majalah Kedokteran Gigi) Journal of Stem Cell Research and Tissue Engineering Medika Respati : Jurnal Ilmiah Kesehatan
David Buntoro Kamandjaja
Department Of Oral And Maxillofacial Surgery, Faculty Of Dental Medicine, Universitas Airlangga
Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Closed reduction in the treatment of neglected mandibular fractures at the Department of Oral and Maxillofacial Surgery, Universitas Airlangga Olivia Jennifer Gunardi; Riska Diana; David Buntoro Kamadjaja; Ni Putu Mira Sumarta
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 3 (2019): September 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p147-153

Abstract

Background: The mandible is one of the bones most affected by facial fractures commonly resulting from trauma to the face. The ultimate goal of treatment is to re-establish the pre-injury dental occlusion (bite), mandibular anatomy and jaw function of the patient. Treatment approaches range from conservative non-invasive management by ’closed’ reduction and immobilization using intermaxillary fixation (IMF) to the more invasive surgery-based ’open’ reduction incorporating an internal fixation approach. Purpose: The purpose of this case series was to describe the close reduction method as a form of treatment in cases of neglected mandibular fracture. Cases: Four cases of single or multiple mandibular fracture were presented. Case management: All of the cases were managed using a closed reduction method and IMF. Conclusion: A closed reduction method in this case series produced encouraging results and could be considered an alternative in the treatment of neglected mandibular fractures with displacement.
RANCANG BANGUN PROTOTIPE 3 DIMENSI ORGAN MANDIBULA MENGGUNAKAN CITRA MEDIS RADIOLOGI Amillia Kartika Sari; Riries Rulaningtyas; Khusnul Ain; Suryani Dyah Astuti; Soegianto Soelistiono; David Buntoro Kamandjaja
Medika Respati : Jurnal Ilmiah Kesehatan Vol 17, No 4 (2022)
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35842/mr.v17i4.762

Abstract

Latar belakang: Tumor pada mandibula dapat menyebabkan kecacatan tulang. hal ini memberikan dampak negatif pada kehidupan sosial penderita. Solusi pada kasus ini adalah operasi rekonstruksi mandibula. Untuk mengoptimalkan operasi tersebut salah satunya dapat digunakan prototipe 3D sebagai perencanaan pra-bedah. Tujuan: Penelitian ini berfokus pada proses pembuatan prototipe 3D yang menggunakan pencitraan dari modalitas CT-Scan. Hasil: Pembuatan prototipe 3D diawali dari akuisisi data citra CT-Scan yang selanjutnya dilakukan proses segmentasi citra dan visualisasi 3 dimensi, pada proses terakhir dilakukan pencetakan 3 dimensi. Prototipe 3D yang telah jadi dilakukan analisa kualitatif melalui pengukuran dimensi panjang di daerah ramus, angulus, dan body of mandible dan dibandingkan dengan hasil pengukuran organ mandibula cadaver. Didapatkan hasil rerata panjang ramus pada mandibula cadaver adalah 33,62±0,34 mm, sedangkan panjang ramus pada mandibula prototipe 3D adalah 32,98±0,44 mm. Nilai rerata pengukuran pada daerah angulus adalah 31,26±0,25 mm pada mandibula cadaver, dan nilai 31,23±0,22 mm pada mandibula protptipe 3D. Dan pengukuran pada daerah body of mandible  mandibula cadaver adalah 32,05±0,98mm, sedangkan apada mandibula prootipe adalah 32,06±1,03 mm, secara keseluruhan akurasi pada prototipe 3D sebesar 99,317%.  Kesimpulan: Penggunaan citra radiologi sebagai data awal untuk membuat prototipe 3 dimensi mandibula dapat dilakukan, pengukuran akurasi prototipe 3D harus dievaluasi untuk masing-masing tahap fabrikasi.
TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION: TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION Kamadjaja, David
Journal of Stem Cell Research and Tissue Engineering Vol. 1 No. 1 (2017): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v1i1.60445

Abstract

Maxillofacial bone defects due to tumor resection, trauma or infections should be reconstructed to maintain the bone continuity in order to preserve its masticatory, speech and esthetic functions. Autogenous bone graft have been the gold standard for mandibular defects reconstruction, however, it is associated with limitation in volume and availability as well as the donor site morbidities. Tissue engineering approach has been proved to be a good alternative to overcome the limitation of autogenous bone graft. Tissue engineering studies have been conducted combining various sources of mesenchymal stem cell, scaffolds, and or signaling molecules. The paper aims to provide information on the development of bone tissue engineering researches to reconstruct bone defects through results of numerous studies obtained in the English literature. As the conclusion, bone tissue engineering is a potential approach to reconstruct maxillofacial bone defects.
Degradation rate and weight loss analysis for freeze-dried, decellularized, and deproteinized bovine bone scaffolds Vidarta, Ramadhan Pramudya; Kamadjaja, David Buntoro; Danudiningrat, Coen Pramono; Amir, Muhammad Subhan; Rizqiawan, Andra; Yuliati , Anita; Darwis, Darmawan
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 1 (2025): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i1.p23-29

Abstract

Background: Mandibular defects, often caused by trauma, tumors, infections, and congenital issues, are commonly treated with bone grafts. Tissue engineering plays a crucial role in bone reconstruction, with scaffolds such as deproteinized bovine bone matrix (DBBM), freeze-dried bovine bone (FDBB), and decellularized FDBB (Dc-FDBB) being studied for their efficacy. Decellularization reduces the antigenic potential of FDBB. These scaffolds are designed to degrade within the body. Purpose: To analyze the weight loss and degradation rates of FDBB and Dc-FDBB materials, using DBBM as a control. Methods: This in vitro experimental study, conducted over 2 months, employed a cross-sectional approach to analyze the weight loss and degradation rates of FDBB, Dc-FDBB, and DBBM scaffolds in a simulated body fluid (SBF) solution. Results: Under dynamic immersion conditions, DBBM exhibited the highest daily weight loss at 0.741% and a degradation rate of 0.466 mg/cm²/day, followed by Dc-FDBB at 0.568% and 0.418 mg/cm²/day and FDBB at 0.525% and 0.385 mg/cm²/day. Under static immersion conditions, DBBM also showed the highest weight loss at 0.255%, with a degradation rate of 0.165 mg/cm²/day, followed by Dc-FDBB at 0.245% and 0.163 mg/cm²/day, and FDBB at 0.168% with a degradation rate of 0.126 mg/cm²/day. Significant differences were observed between scaffold groups (p = 0.000). Conclusion: DBBM, Dc-FDBB, and FDBB scaffolds meet the optimal requirements for tissue engineering materials based on their weight loss and degradation rates. DBBM demonstrated the highest values among the scaffolds analyzed.
Immuno-expression analysis of VEGF and CD34 related to histological types of mandibular ameloblastoma Pradana, Septian; Kamadjaja, David Buntoro; Danoediningrat, Coen Pramono; Sumarta, Ni Putu Mira; Amir, Muhammad Subhan; Rahayu, Retno Pudji; Bhagat, James Antony
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 2 (2025): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i2.p144-150

Abstract

Background: Increased expression of vascular endothelial growth factor (VEGF) and cluster of difference 34 (CD34) in ameloblastoma has been noted. Both proteins are markers of angiogenesis that play a role in supporting the growth of ameloblastoma. The existence of histopathological types of ameloblastoma allows for differences in behavioral and growth characteristics. Purpose: To evaluate the differences and correlation of VEGF and CD34 expression in histological types of ameloblastoma. Methods: This laboratory cross-sectional study uses total sampling from histological slides of mandibular ameloblastoma. Two observers manually quantified the immunohistochemical expression. The comparative data were analyzed statistically with the Kruskal–Wallis test (p < 0.05), while the correlative data were analyzed with Spearman’s rho (p<0.01). Results: 32 samples were obtained according to the inclusion criteria. The Kruskal–Wallis test showed significant differences in VEGF expression (p = 0.003) and CD34 expression (p = 0.026). The pairwise comparison test showed that VEGF expression in follicular ameloblastoma significantly differed from plexiform (p = 0.001) and combination (p = 0.002). The pairwise comparison test for CD34 expression showed a significant difference between follicular and combination ameloblastoma (p = 0.007). Spearman’s rho test showed a positive correlation (p = 0.001, r = 0.565) between markers. Conclusion: Follicular ameloblastoma expressed higher VEGF than plexiform and combination ameloblastoma. Follicular ameloblastoma expressed higher CD34 than combination types. CD34 expression is associated with VEGF in histological types of ameloblastoma.
The Osteogenic Capacity of HumanAmniotic Membrane Mesenchymal Stem Cell (hAMSC) and Potential for Application in Maxillofacial Bone Reconstruction in Vitro Study Kamadjaja, David
Journal of Stem Cell Research and Tissue Engineering Vol. 4 No. 1 (2020): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v4i1.21590

Abstract

Amniotic membrane of human placenta is a source of abundant mesenchymal stem cell (hAMSC) which makes it a potential source of allogeneic multipotent cell for bone healing.  However, much has to be explored about its isolation procedure and the osteogenic differentiation potential. The aims of this study are to establish the procurement procedure of human amniotic membrane, the isolation   and culture   of hAMSC, the MSC phenotypic characterization, and the in vitro osteogenic differentiation of hAMSC.  Results of the study are as follows. The quality of human amniotic membrane would be best if procured from Caesarean operation under highly aseptic condition to avoid fungal and bacterial contamination on the culture.  Isolation procedure using modified   Soncini protocol yielded large amount of MSC with high proliferative capacity in culture medium.  Characterization of hAMSC showed that the majority of the target cells exhibited specific MSC markers (CD10S and CD90) with a small number of these cells expressing CD45the marker of hematopoeitic cells. The in vitro osteogenic differentiation of hAMSC  followed by Alizarin  Red staining showed that  osteoblastic differentiation  was  detected in a significantly   high  number  of cells.  This study concludes that hAMSCs isolated from human amniotic membrane have the capacity for in vitro osteogenesis which makes them be one of the potential allogeneic stem cells for application in maxillofacial bone reconstruction.
Co-Authors Amillia Kartika Sari Amir, Muhammad Subhan Andra Rizqiawan Bhagat, James Antony Danoediningrat, Coen Pramono Darin Hulwani Rinaldi Darmawan Darwis Djodi Asmara Gita Khairana Haryono Utomo Khusnul Ain Ni Putu Mira Sumarta Olivia Jennifer Gunardi R. Soesanto Retno Pudji Rahayu Riries Rulaningtyas Riska Diana RM Coen Pramono D Septian Pradana, Septian Soegianto Soelistiono Suryani Dyah Astuti Vidarta, Ramadhan Pramudya Yuli Nugraeni Yuliati , Anita