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All Journal Dental Journal (Majalah Kedokteran Gigi)
David B. Kamadjaja
Department Of Oral And Maxillofacial Surgery, Faculty Of Dental Medicine, Universitas Airlangga
Dentistry

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Closed reduction in the treatment of neglected mandibular fractures at the Department of Oral and Maxillofacial Surgery, Universitas Airlangga Olivia Jennifer Gunardi; Riska Diana; David Buntoro Kamadjaja; Ni Putu Mira Sumarta
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 3 (2019): September 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p147-153

Abstract

Background: The mandible is one of the bones most affected by facial fractures commonly resulting from trauma to the face. The ultimate goal of treatment is to re-establish the pre-injury dental occlusion (bite), mandibular anatomy and jaw function of the patient. Treatment approaches range from conservative non-invasive management by ’closed’ reduction and immobilization using intermaxillary fixation (IMF) to the more invasive surgery-based ’open’ reduction incorporating an internal fixation approach. Purpose: The purpose of this case series was to describe the close reduction method as a form of treatment in cases of neglected mandibular fracture. Cases: Four cases of single or multiple mandibular fracture were presented. Case management: All of the cases were managed using a closed reduction method and IMF. Conclusion: A closed reduction method in this case series produced encouraging results and could be considered an alternative in the treatment of neglected mandibular fractures with displacement.
Degradation rate and weight loss analysis for freeze-dried, decellularized, and deproteinized bovine bone scaffolds Vidarta, Ramadhan Pramudya; Kamadjaja, David Buntoro; Danudiningrat, Coen Pramono; Amir, Muhammad Subhan; Rizqiawan, Andra; Yuliati , Anita; Darwis, Darmawan
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 1 (2025): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i1.p23-29

Abstract

Background: Mandibular defects, often caused by trauma, tumors, infections, and congenital issues, are commonly treated with bone grafts. Tissue engineering plays a crucial role in bone reconstruction, with scaffolds such as deproteinized bovine bone matrix (DBBM), freeze-dried bovine bone (FDBB), and decellularized FDBB (Dc-FDBB) being studied for their efficacy. Decellularization reduces the antigenic potential of FDBB. These scaffolds are designed to degrade within the body. Purpose: To analyze the weight loss and degradation rates of FDBB and Dc-FDBB materials, using DBBM as a control. Methods: This in vitro experimental study, conducted over 2 months, employed a cross-sectional approach to analyze the weight loss and degradation rates of FDBB, Dc-FDBB, and DBBM scaffolds in a simulated body fluid (SBF) solution. Results: Under dynamic immersion conditions, DBBM exhibited the highest daily weight loss at 0.741% and a degradation rate of 0.466 mg/cm²/day, followed by Dc-FDBB at 0.568% and 0.418 mg/cm²/day and FDBB at 0.525% and 0.385 mg/cm²/day. Under static immersion conditions, DBBM also showed the highest weight loss at 0.255%, with a degradation rate of 0.165 mg/cm²/day, followed by Dc-FDBB at 0.245% and 0.163 mg/cm²/day, and FDBB at 0.168% with a degradation rate of 0.126 mg/cm²/day. Significant differences were observed between scaffold groups (p = 0.000). Conclusion: DBBM, Dc-FDBB, and FDBB scaffolds meet the optimal requirements for tissue engineering materials based on their weight loss and degradation rates. DBBM demonstrated the highest values among the scaffolds analyzed.
Immuno-expression analysis of VEGF and CD34 related to histological types of mandibular ameloblastoma Pradana, Septian; Kamadjaja, David Buntoro; Danoediningrat, Coen Pramono; Sumarta, Ni Putu Mira; Amir, Muhammad Subhan; Rahayu, Retno Pudji; Bhagat, James Antony
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 2 (2025): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i2.p144-150

Abstract

Background: Increased expression of vascular endothelial growth factor (VEGF) and cluster of difference 34 (CD34) in ameloblastoma has been noted. Both proteins are markers of angiogenesis that play a role in supporting the growth of ameloblastoma. The existence of histopathological types of ameloblastoma allows for differences in behavioral and growth characteristics. Purpose: To evaluate the differences and correlation of VEGF and CD34 expression in histological types of ameloblastoma. Methods: This laboratory cross-sectional study uses total sampling from histological slides of mandibular ameloblastoma. Two observers manually quantified the immunohistochemical expression. The comparative data were analyzed statistically with the Kruskal–Wallis test (p < 0.05), while the correlative data were analyzed with Spearman’s rho (p<0.01). Results: 32 samples were obtained according to the inclusion criteria. The Kruskal–Wallis test showed significant differences in VEGF expression (p = 0.003) and CD34 expression (p = 0.026). The pairwise comparison test showed that VEGF expression in follicular ameloblastoma significantly differed from plexiform (p = 0.001) and combination (p = 0.002). The pairwise comparison test for CD34 expression showed a significant difference between follicular and combination ameloblastoma (p = 0.007). Spearman’s rho test showed a positive correlation (p = 0.001, r = 0.565) between markers. Conclusion: Follicular ameloblastoma expressed higher VEGF than plexiform and combination ameloblastoma. Follicular ameloblastoma expressed higher CD34 than combination types. CD34 expression is associated with VEGF in histological types of ameloblastoma.
Co-Authors Amir, Muhammad Subhan Andra Rizqiawan Bhagat, James Antony Danoediningrat, Coen Pramono Darin Hulwani Rinaldi Darmawan Darwis Djodi Asmara Gita Khairana Haryono Utomo Ni Putu Mira Sumarta Olivia Jennifer Gunardi R. Soesanto Retno Pudji Rahayu Riska Diana RM Coen Pramono D Septian Pradana, Septian Vidarta, Ramadhan Pramudya Yuli Nugraeni Yuliati , Anita