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All Journal Jurnal Online Mahasiswa (JOM) Bidang Perikanan dan Ilmu Kelautan Indonesian Journal of Pharmacology and Therapy
Mardiana Siregar
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Earth & Planetary Sciences Immunology & microbiology Medicine & Pharmacology

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RED BLOOD CELLS OF THE SIAMESE JAMBAL (Pangasius hypophthalmus) FEED CONTAINING HYDROVAC VACCINE Mardiana Siregar; Morina Riauwaty; Iesje Lukistyowati
Jurnal Online Mahasiswa (JOM) Bidang Perikanan dan Ilmu Kelautan Vol 7, No 1 (2020): Edisi 1 Januari - Juni 2020
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Perikanan dan Ilmu Kelautan

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Abstract

ABSTRACKVaccines are weakened microorganisms aimed at raising the immunity of fish against a particular disease. The purpose of this research is to find out what is the best dosage of feed containing HydoVac vaccine on Siamese jambal siam fish (Pangasius hypophthalmus). This research has been conducted in April to August 2019 which is housed in the parasitic laboratory and fish disease Faculty of Fisheries and Marine of Riau University. The test fish used is the seed of a Siamese jambal siam fish that measures 8-10 cm by 150 tails.The method used in this research is a method of experimental with the complete random draft (RAL) a factor of 5 levels of treatment and 3 times repeated, the treatment is Kn (feeding without the Hydrovac vaccine and without test challenge with bacteria Aeromonas hydrophila), Kp (giving feed without HydroVac vaccine and test challenge with bacteria Aeromonas Hydrophila), P1 (addition of Hydrovac vaccine on feed at a dose of 6 ml/kg feed), P2 (the addition of Hydrovac vaccine in the feed at a dose of 8 ml/kg feed) and P3 (the addition of Hydrovac vaccine in the feed at a dose of 10 ml/kg feed). Fish maintained for 30 days in the aquarium, Test Challenge on the 31st day using the bacteria Aeromonas hydrophila. The measured parameters are total erythrocytes, hemoglobin concentration, hematocrit value, fatigue, relative percent survival (RPS), and absolute weight growth. Results showed that the addition of HydoVac vaccine on the feed can prevent the disease Motile Aeromonas Septicemia (MAS), judging from the total average eritosit 139x104 cells/mm3, hemoglobin 6,22 g/dL, Hematocrit value 25,11%, life 90%, relative percent survival (RPS) 85,18% and total weight growth 11.76 G. Based on the obtained data can be concluded that the addition of HydroVac vaccine in feed is able to increase the body resistance of the Siamese Jambal siam (Pangasius hypophthalmus).Keywords: Pangasius hyphophthalmus, vaccine HydroVac, Aeromonas hydrophila,
Comparison between metformin and glibenclamide as antidiabetic oral in gestational diabetes mellitus: a review Ridhayani, Firda; I Dewa Agung Ayu Diva Candraningrat; Ilmi Nurhafizah; Karina Nurlitasari; Mardiana Siregar
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.5867

Abstract

Gestational diabetes mellitus (GDM) is one of the most frequent clinical complications during pregnancy that affects up to 6% of women with pregnancies around the world. Gestational diabetes mellitus treatment used insulin as first-line therapy. In addition, several professional associations are also considering treatment using antidiabetic oral which has equivalent efficacy compared with insulin. However, many oral antidiabetic recommendations have been administered to treat GDM, including metformin and glyburide or glibenclamide. This article’s review aims to compare the usage between metformin and glyburide or glibenclamide in GDM patients. This review compared research results from PubMed as literature resources and the PRISMA flow chart as the protocol for the article selection process. Based on inclusion and exclusion criteria there are six research articles that are appropriate to the article’s topic and aim. Metformin is superior compared with glyburide or glibenclamide administration as antidiabetic oral in GDM. Metformin showed a significant effect in lowering preprandial and postprandial glucose level, elevating insulin sensitivity, while glibenclamide administration decreased dynamic pancreatic β-cell responsivity significantly and had a higher risk compared with insulin and metformin.
Co-Authors Firda Ridhayani I Dewa Agung Ayu Diva Candraningrat Iesje Lukistyowati Ilmi Nurhafizah Karina Nurlitasari